5,002,722 papers found

The authors discuss 3 challenges in conducting and interpreting any systematic review that are particularly relevant for systematic reviews of therapeutic devices or surgical procedures: 1) inclusion or exclusion of grey literature, 2) the role of nonrandomized studies, and 3) issues in applying the results to clinical…

BACKGROUND: Ewing's sarcomas account for approximately 10% of primary malignant bone tumors. While most of the primary Ewing's sarcomas occur in the long bones, pelvis, or ribs, approximately 1-6% of these sarcomas arise in the skull. We found approximately 50 cases of Ewing's sarcoma of the calvarium reported in our s…

The surgical correction of spinal deformities carries a high risk of perioperative morbidity. As the incidence of debilitating spinal deformities continues to increase, so too does our obligation to search for ways to enhance safety in our delivery of surgical care. Standardized work processes and other lean manufactur…

BACKGROUND AND PURPOSE: Acupotomy is a modern type of acupuncture that uses a blade-needle combined with a flat surgical scalpel at its tip. This study was conducted to summarize and critically evaluate the current evidence on acupotomy. MATERIALS AND METHODS: All relevant studies up to February 19, 2019, were include…

INTRODUCTION: Systematic reviews represent the primary level of evidence (level I evidence) and an excellent answer to causality questions. They should be based upon high quality standards and the critical appraisal of such study design is fundamental. METHODS: In this review we introduce the primary indicators of qua…

Systematic reviews (SRs) and meta-analyses are regarded as the pinnacle of evidence-based medicine, synthesizing fragmented research to guide clinical decision-making. However, the exponential increase in their publication has raised concerns regarding redundancy, methodological flaws, and misleading conclusions. Many…

OBJECTIVE: To summarize the role of antenatal risk factors for infant cerebral palsy (CP) by un umbrella review. DATA SOURCES: Pubmed, Cochrane list of trials, Medline and Google Scholar were searched for meta-analyses and systematic reviews, published between September 2009 and August 2025. STUDY ELIGIBILITY CRITERI…

PURPOSE: This umbrella review aimed to investigate the evidence for an association of dietary intake of total protein as well as animal and plant protein with the incidence of coronary heart disease (CHD), stroke and total cardiovascular diseases (CVD). METHODS: PubMed, Embase and Cochrane Database were systematically…

OBJECTIVES: To identify, summarize, and analyze published comments relevant to the PRISMA-P (Preferred Reporting Items for Systematic reviews and Meta-Analyses Protocols) 2015 reporting guideline for systematic review protocols, with special emphasis on suggestions for guideline modifications. METHODS: We included doc…

INTRODUCTION: This umbrella review identified the current high-quality systematic reviews on e-cigarettes as a smoking cessation aid. What is the comparative effectiveness of e-cigarettes compared to other cessation treatments or approaches? We also investigated the systematic reviews for reporting biases. METHODS: Th…

BACKGROUND: Chronic pain, considered to be pain lasting more than three months, is a common and often difficult to treat condition that can significantly impact upon function and quality of life. Treatment typically includes pharmacological and non-pharmacological approaches. Transcutaneous electrical nerve stimulation…

BACKGROUND: Overviews are a new approach to summarising evidence and synthesising results from related systematic reviews. OBJECTIVES: To conduct an overview of Cochrane systematic reviews to provide a contemporary review of the evidence for delivery of cardiac rehabilitation, to identify opportunities for merging or…

: to systematically evaluate the evidence on anthocyanins' health effects through an umbrella review of systematic reviews and meta-analyses.: we searched four databases (PubMed, EMBASE, Cochrane Library, and APA PsycINFO) using a predefined search strategy. The methodological quality of included meta-analyses was crit…

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used medications that function by inhibiting cyclooxygenase enzymes. Although they are highly effective in managing pain and inflammation, their potential for increasing bleeding risks continues to be a concern. Due to the increased risk for bleeding complication…

OBJECTIVE: The number of published systematic reviews has exploded in the past three decades, followed by a large number of overlapping systematic reviews on the same topic. We aim to review the frequency and causes of overlap in systematic reviews. METHODS: Following PRISMA 2020 guidelines, we searched PubMed and Emb…

: More than a billion people worldwide suffer from chronic periodontitis. The primary etiological factor of periodontal diseases is dental plaque and the bacteria it contains, particularly,,,, and. Zinc, owing to its antibacterial properties, can be employed in periodontology. The objective of this review was to analyz…

OBJECTIVE: To compare disease-free survival rates in oral squamous cell carcinoma patients initially attended and referred by dentists versus other physicians. METHODS: The systematic review was conducted after registration with the International prospective register of systematic reviews at the University of York, th…

BACKGROUND: Inconsistencies between a protocol and its umbrella review (UR) may mislead readers about the importance of findings or lead to false-positive results. Furthermore, not documenting and explaining inconsistencies in the UR could reduce its transparency. To our knowledge, no study has examined the methodologi…

While there is some research investigating whole foods or diets that are easily understood and accessible to patients with osteoarthritis, specific nutrients or nutraceuticals are more commonly identified. Unfortunately, guidelines and evidence surrounding individual nutrients, extracts, and nutraceuticals are conflict…

OBJECTIVE: To conduct an overview of meta-analyses evaluating the impact of exercise interventions on improving health outcomes in patients with chronic kidney disease (CKD). DESIGN: An umbrella review of systematic review and meta-analyses of intervention trials was performed. DATA SOURCES: PubMed, Web of Science, E…