5,082,997 papers found

Xanthogranulomatous inflammation is a rare clinico-pathological condition involving many organ systems. Breast involvement with this rare condition reported from a few cases of mastitis has been limited to only microscopic involvement on histology. We would like to report an unusual presentation of this inflammatory pr…

Nephrologists often search for clinical information to guide patient care, especially in the chronic kidney disease patient population where information needs are complex. Applying evidence-based principles while searching for current high-quality information can be challenging. This article details the "6S" framework…

AIM: Since 2007 we have been focusing our attention to EJPRM as the best available clinical evidence as offered by the Cochrane Collaboration. Due to the absence of a specific Rehabilitation Group (only a Field does exist), some reviews in the field of PRM are not easy to find. Consequently, the EJPRM lists and present…

BACKGROUND: Cochrane systematic reviews are of higher quality than reviews published in scientific journals, yet are used less than other sources for clinical decision-making. AIM: To assess whether the characteristics of the Cochrane systematic reviews can account for their scant use by physicians. MATERIALS AND MET…

In the process of undertaking a meta-synthesis of qualitative studies of free-standing midwife-led units, the authors of this paper encountered a number of methodologically and epistemologically unresolved issues. One of these related to the assessment of the quality of qualitative research. In an iterative approach to…

Economic evaluations of the various interventions available for low back pain will help clinicians and policymakers to identify the most beneficial treatment. This chapter aims to evaluate the most cost-effective treatments for patients with non-specific low back pain. Pubmed, Embase and the Cochrane library were used…

OBJECTIVE: In 2003, critical care and infectious disease experts representing 11 international organizations developed management guidelines for fluid resuscitation in severe sepsis and septic shock that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, an interna…

Reviewing publications from two North American functional appliance efficacy trials on Class II/1 malocclusions, we conclude that preadolescents show first molar correction in 13% of untreated cases, 38% of bionator-treated cases, and 50% of combined headgear/biteplane-treated cases. Also, bionator and headgear reduce…

OBJECTIVE: The professional literature on Munchausen by Proxy (MBP) abuse consists of more than 400 articles, chapters, and books. Most have come from a handful of English-speaking industrialized countries. Our aims were to establish the extent to which published work about MBP has emerged from outside these countries,…

OBJECTIVES: To synthesise evidence from existing systematic reviews on the effectiveness of mental health interventions for healthcare professionals and examine the contextual factors influencing their implementation and impact. STUDY DESIGN: Umbrella review of systematic reviews evaluating interventions to support th…

This review paper provides an overview of the Scientific Advisory Committee on Nutrition's (SACN's) report. The purpose of the report was to (1) review the scientific basis of current recommendations for feeding children aged 1 to 5 years, (2) consider evidence on developmental stages and other factors that influence e…

BackgroundArtificial intelligence (AI) has rapidly gained momentum in the field of orthopaedics, with an increasing number of systematic reviews and meta-analyses providing synthesised evidence. However, most studies have focused on individual subspecialties or specific applications, and a comprehensive overview across…

: to systematically evaluate the evidence on anthocyanins' health effects through an umbrella review of systematic reviews and meta-analyses.: we searched four databases (PubMed, EMBASE, Cochrane Library, and APA PsycINFO) using a predefined search strategy. The methodological quality of included meta-analyses was crit…

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used medications that function by inhibiting cyclooxygenase enzymes. Although they are highly effective in managing pain and inflammation, their potential for increasing bleeding risks continues to be a concern. Due to the increased risk for bleeding complication…

OBJECTIVE: The number of published systematic reviews has exploded in the past three decades, followed by a large number of overlapping systematic reviews on the same topic. We aim to review the frequency and causes of overlap in systematic reviews. METHODS: Following PRISMA 2020 guidelines, we searched PubMed and Emb…

: More than a billion people worldwide suffer from chronic periodontitis. The primary etiological factor of periodontal diseases is dental plaque and the bacteria it contains, particularly,,,, and. Zinc, owing to its antibacterial properties, can be employed in periodontology. The objective of this review was to analyz…

OBJECTIVE: To compare disease-free survival rates in oral squamous cell carcinoma patients initially attended and referred by dentists versus other physicians. METHODS: The systematic review was conducted after registration with the International prospective register of systematic reviews at the University of York, th…

BACKGROUND: Inconsistencies between a protocol and its umbrella review (UR) may mislead readers about the importance of findings or lead to false-positive results. Furthermore, not documenting and explaining inconsistencies in the UR could reduce its transparency. To our knowledge, no study has examined the methodologi…

While there is some research investigating whole foods or diets that are easily understood and accessible to patients with osteoarthritis, specific nutrients or nutraceuticals are more commonly identified. Unfortunately, guidelines and evidence surrounding individual nutrients, extracts, and nutraceuticals are conflict…

OBJECTIVE: To conduct an overview of meta-analyses evaluating the impact of exercise interventions on improving health outcomes in patients with chronic kidney disease (CKD). DESIGN: An umbrella review of systematic review and meta-analyses of intervention trials was performed. DATA SOURCES: PubMed, Web of Science, E…