5,082,997 papers found

Systematic reviews (SR) are a recognised standard for synthesising clinical data in order to support evidence-based clinical decisions. A robust search strategy is the core of an SR, requiring theoretical and methodological considerations in the pre-, intra- and post-search stage. This review discusses the competencies…

At the end of 2012, Chinese Society of Clinical Oncology (CSCO) amended and revised the expert consensus of gastrointestinal stromal tumor (GIST) 2011. This article is respectively review hot topics regarding surgical intervention during the revision, including principles and indications of biopsy and surgery.

Migraine is a common disabling malady. Despite the development of therapeutic agents such as the triptans, a significant number of patients continue to suffer. The evolution of peripheral nerve stimulation for headache management, may significantly improve the management of those who suffer from moderate to refractory…

BACKGROUND: Systematic reviews are an important tool of evidence-based surgery. Surgical systematic reviews and trials, however, require a special methodological approach. PURPOSE: This article provides recommendations for conducting state-of-the-art systematic reviews in surgery with or without meta-analysis. CONCLU…

OBJECTIVE: PROSPERO, an international prospective register of systematic reviews, was launched in February 2011 to reduce publication bias of systematic reviews (SRs). A questionnaire survey of SR researchers conducted in 2005 indicated the existence of unpublished SRs and the potential influence of lack of funding as…

Updating of systematic reviews is generally more efficient than starting all over again when new evidence emerges, but to date there has been no clear guidance on how to do this. This guidance helps authors of systematic reviews, commissioners, and editors decide when to update a systematic review, and then how to go a…

BACKGROUND: Anemia during pregnancy affects more than one-third of women globally, with the heaviest burden in low- and middle-income countries. It contributes substantially to maternal morbidity, adverse birth outcomes, and increased neonatal mortality. Despite extensive research, there remains a lack of comprehensive…

The number of literature reviews in the fields of ecology and conservation has increased dramatically in recent years. Scientists conduct systematic literature reviews with the aim of drawing conclusions based on the content of a representative sample of publications. This requires subjective judgments on qualitative c…

INTRODUCTION AND OBJECTIVES: A Consensus document on the management of patients with neurogenic detrusor overactivity (NDO) was published in 2018. The present document aims to update its recommendations regarding treatment considering the new evidence available, and to contribute to the standardization of the managemen…

INTRODUCTION: With the varied literature on osteoporotic vertebral fracture that may predispose to diagnostic and management dilemma, it is timely to evaluate and streamline the evidence. The aim of this review is to create recommendations on osteoporotic vertebral fractures regarding radiologic diagnosis, and clinical…

Numerous Cochrane Reviews (CRs) in the field of physiotherapy have been published, but their conclusiveness has not been investigated. The purpose of this study was to provide an overview and describe the conclusiveness of evidence from CRs regarding physiotherapy. We conducted a systematic search using the Cochrane Da…

INTRODUCTION: The purposes of this study were to determine how many systematic reviews and meta-analyses relating to temporomandibular disorders (TMDs) had been published as of 2017 compared with those published as of 2004 and then to summarize the findings, based on an analysis of the abstracts from those studies. ME…

BACKGROUND: The top-cited systematic reviews/meta-analyses in tuberculosis research have not been identified. The objective of this study was to identify the 100 top-cited systematic reviews/meta-analyses in tuberculosis research, and to understand factors resulting in highly cited works, and establish trends in system…

BACKGROUND: Few guidelines exist for the initial management of wounds in disaster settings. As wounds sustained are often contaminated, there is a high risk of further complications from infection, both local and systemic. Healthcare workers with little to no surgical training often provide early wound care, and where…

Abstract We report a case of a 17-year-old girl with a history of congenital human immunodeficiency virus (HIV) infection and lipodystrophy secondary to highly active antiretroviral therapy (HAART). She developed severe worsening of preexisting hypertriglyceridemia after treatment with oral contraceptive pills (OCP) fo…

BACKGROUND: Malignant triton tumors are relatively rare and highly aggressive tumors in which malignant schwannoma cells coexist with rhabdomyoblasts. Their occurrence in the retroperitoneum is uncommon and has been rarely reported. CASE PRESENTATION: We present the case of a patient with a retroperitoneal malignant t…

OBJECTIVES: To determine whether individual patient data meta-analyses (IPDMA) are used to perform subgroup analyses and to study whether the analytical methods regarding subgroup analyses differ between IPDMA and conventional meta-analyses (CMA). STUDY DESIGN AND SETTING: IPDMA were identified with a comprehensive li…

PURPOSE OF REVIEW: To summarize recent findings and developments in the field of the relation between white-matter lesions and cognition. RECENT FINDINGS: Recent studies have provided further evidence that white-matter lesions exert a detrimental effect on cognitive profile. New magnetic-resonance techniques may help…