2,693 papers found

BACKGROUND: Diagnostic testing is overused in emergency departments, and clinical decision support may reduce unnecessary ordering. We examined the effects of nudge-based clinical decision support interventions on test ordering among emergency department clinicians. METHODS: This triple-blind four-arm parallel (1:1:1:…

We report here on focusing of a probe IR (λ = 1.55 μm) laser beam in silicon. The focusing is done by a second pump laser beam, at λ = 0.775 μm and 30 ps pulse width, with a donut shape that is launched collinearly and simultane…

BACKGROUND: Previous studies report varying rates of time-loss injuries in adolescent female soccer, ranging from 2.4 to 5.3 per 1000 athlete-exposures or 2.5 to 3.7 per 1000 hours of exposure. However, these studies collected data using traditional injury reports from coaches or medical staff, with methods that signif…

OBJECTIVE: To evaluate the effectiveness of eletriptan for acute migraine treatment and patient satisfaction with the drug in usual clinical practice settings. METHODS: Male and female patients of practicing neurologists, aged 18 to 65 years, were eligible for inclusion in the study if they met International Headache…

BACKGROUND: In the diagnostic process of monogenic genetic disorders, identifying pathogenic variants is a crucial step. Thanks to the widespread adoption of Next-Generation Sequencing (NGS) technology, diagnostic efficiency has been significantly enhanced. However, with the increasing demand for diagnostic accuracy in…

OBJECTIVES: To evaluate ChatGPT's ability to perform thematic analysis of medical Best Practice Advisory (BPA) free-text comments and identify prompt engineering strategies that optimize performance. MATERIALS AND METHODS: We analyzed 778 BPA comments from a pilot AI-enabled clinical deterioration intervention at Stan…

The front cover artwork is provided by the Mosquera group at Montana State University, Bozeman. The image shows theoretical elements involved in the density-functional calculations that are free of spurious fractional charges. Read the full text of the Research Article at 10.1002/cphc.202200592.

The aim of the article is to explain in more detail the biomechanical methods used in determining bone quality as well as to describe basic characteristic bone qualities resulting from the application of these methods. Mechanical properties of biomaterials are characterised by stress-strain curves, produced on the basi…

OBJECTIVE: To asses the complex anti-reflux treatment of pure venous ulcers on all levels of venous system. PATIENTS: In the last 20 years the authors treated 793 patients with venous ulceration and compared the therapeutic results of 4 groups of patients treated either surgically (Linton+v.v. surgery) or with sclerot…

The process of communication between brain and spinal cord remains unclear. Therefore an attempt supported by spinal cord stereotaxy was made to disclose the physiological mechanisms underlying the cooperation between the brain and spine as generated by the spinal cord. The initializing stimulus was the discovery of mo…

Multimodal behavioral sensing may support depression screening, but evaluation on small clinical-interview datasets is particularly vulnerable to data leakage and model-selection bias. We present a leakage-audited trimodal framework evaluated on DAIC-WOZ (n=180, PHQ-8 ≥10), combining SBERT text embeddings, OpenF…

Background The prevalence of thyroid transcription factor-1 (TTF-1) and napsin A expression are poorly characterized in lung core biopsies of small cell carcinoma. Locally, the TTF-1 clone is 8G7G3/1 (Agilent/Dako), and the napsin A clone is IP64 (Leica Biosystems). Methods All in-house lung core biopsy reports for cas…

Invited for the cover of this issue is the group of Dillip Kumar Chand at the Indian Institute of Technology Madras. The image depicts the efficient chloride binding ability of a designer self-assembled coordination cage in water. The binding occurs selectively even in presence of models of biologically abundant anioni…

MOTIVATION: Converting the vast quantity of free-format text found in journals into a concise, structured format makes the researcher's quest for information easier. Recently, several information extraction systems have been developed that attempt to simplify the retrieval and analysis of biological and medical data. M…

We have previously described a free, public web-based tool, Trials to Publications, https://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/TrialPubLinking/trial_pub_link_start.cgi , which employs a machine-learning model based on title, abstract, and other metadata features to predict which publications are likely to…

The Carbohydrate Structure Database (CSDB, http://csdb.glycoscience.ru/ ) is a free curated repository storing various data on glycans of bacterial, fungal and plant origins. Currently, it maintains a close-to-full coverage on bacterial and fungal carbohydrates up to the year 2020. The CSDB web-interface provides free…

The circular code theory proposes that genes are constituted of two trinucleotide codes: the classical genetic code with 61 trinucleotides for coding the 20 amino acids (except the three stop codons {TAA,TAG,TGA}) and a circular code based on 20 trinucleotides for retrieving, maintaining and synchronizing the reading f…

Invited for the cover of this issue are Sabine Schneider, Tobias A. M. Gulder and co-workers at Technical University of Dresden, Technical University of Munich and Ludwig-Maximillians-University Munich. The image depicts the crystal structure of the cytochrome P450 AryC from arylomycin biosynthesis. Read…

Cytometry is becoming a standard method of examination not only in biology but also in various fields of experimental and clinical medicine. While in flow cytometry suspensions of cells are measured, laser scanning cytometers enable both the measurement of cells in single-cell suspensions (after immobilising the cells…

Countries traditionally consuming beer and wine have high alcohol consumption as compared to East Asia, where the fact of low alcoholism prevalence can be attributed to a defect in metabolic degradation of ethanol. Dependence on alcohol is multifactorial and is related to a complex interplay of metabolic, genetic, soci…