2,645 papers found

BACKGROUND AND OBJECTIVES: Cenobamate is a novel antiseizure medication (ASM) approved by the Food and Drug Administration for use as adjunctive therapy in focal epilepsy. However, there are limited data on its use as a standalone monotherapy. The aim of our study was to investigate the use of cenobamate monotherapy an…

OBJECTIVE: Biomedical knowledge graphs (KGs) such as PrimeKG, Hetionet, UMLS, and PharmGKB are increasingly used as the substrate for downstream machine-learning, retrieval-augmented generation, drug-repurposing, and electronic health record (EHR) augmentation pipelines. The dominant assumption in published work is tha…

BACKGROUND: A minority of Pulmonary and Critical Care Medicine (PCCM) graduates pursue careers in academic medicine. Although compensation is only a portion of the career decision, job negotiations remain shrouded in ambiguity and inconsistency. Additionally, while role-level salary tables exist through the Association…

remains a leading cause of invasive diseases, particularly affecting young children and the elderly. Currently, two main types of pneumococcal vaccines are commercially available: polysaccharide vaccine (PPSV23) and conjugate vaccines (e.g., PCV20). Of over 100 identified pneumococcal serotypes, vaccines targeting 24 s…

PURPOSE: This study aimed to provide insights into the staffing and workflow requirements for cone beam computed tomography (CBCT)-guided online adaptive radiation therapy (ART) systems to guide institutions in optimizing staffing strategies and to promote broader ART adoption. METHODS AND MATERIALS: We conducted a na…

BACKGROUND: Food allergies (FAs) are a significant public health concern, affecting 6-8% of children worldwide, with a growing prevalence. Schools are high-risk environments for allergic reactions, including anaphylaxis, which can be life-threatening. Alarmingly, up to 16-18% of children with FAs experience allergic re…

Bone tissue regeneration is a critical aspect of dental surgery, given the common occurrence of bone resorption leading to alveolar bone defects. The aim of this paper was to conduct a systematic review to provide a comprehensive summary of the evidence regarding the regenerative properties of dentin biomaterial. This…

PURPOSE: To review the published literature assessing the safety and effectiveness of laser refractive surgery to treat anisometropic amblyogenic refractive error in children aged ≤ 18 years. METHODS: A literature search of the PubMed database was conducted in October 2021 with no date limitations and restricte…

BACKGROUND: Since there is still controversy about the comparison of the efficacy and safety of RH and RFA in the treatment of recurrent liver cancer, we conducted a meta-analysis to compare the efficacy and safety, in order to provide evidence-based evidence for future research and clinical treatment. METHODS: We sea…

INTRODUCTION: Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors have been increasingly used in the treatment of cancer. Immunosuppressive therapy can control the cancer well and is suitable for the moderate to severe diseases. However, according to clinical observation, immune-related…

Milk and dairy products containing milk fat are major food sources of saturated fatty acids, which have been linked to increased risk of cardiovascular-related clinical outcomes such as cardiovascular disease (CVD), coronary heart disease (CHD), and stroke. Therefore, current recommendations by health authorities advis…

BACKGROUND: Obesity is a worldwide epidemic in children and adolescents. Adult cohort studies have reported an association between higher body mass index (BMI) and increased leukemia-related mortality; whether a similar effect exists in childhood leukemia remains controversial. OBJECTIVE: We conducted a meta-analysis…

BACKGROUND: Anti-leukotrienes agents are currently being studied as alternative first line agents to inhaled corticosteroids in mild to moderate chronic asthma. OBJECTIVES: To compare the safety and efficacy of anti-leukotriene agents with inhaled glucocorticoids (ICS) and to determine the dose-equivalence of anti-leu…

BACKGROUND: Pain is common in emergency medical services, and abdominal pain is among the most frequent complaints. This study examined whether documented pain assessment, analgesic treatment, reassessment, and documented end-of-encounter pain status in patients with acute abdominal pain differed by clinician competenc…

BACKGROUND: The global population aged ≥60 years will reach 2.1 billion by 2050. Mobility decline is a critical precursor of disability, hospitalization, and mortality in older adults, yet clinic-based assessments may have limited ecological validity and miss subtle deteriorations observable only under free-livi…

PURPOSE: Percutaneous thermal ablation of hypervascular liver tumors is limited by lesion conspicuity on conventional imaging, challenges with ablative margin assessment, and unequal global access to advanced technologies such as ablation confirmation software and radioembolization. This review describes the selective…

Clear documentation and transfer of information between health care providers is key to ensuring the delivery of high-quality patient care. Our aim was to determine how to optimize and standardize physician documentation in outpatient epilepsy clinics as well as to highlight challenges and barriers to their implementat…

OBJECTIVE: The role of elective neck dissection (END) in clinically node negative (cN0) locally advanced cutaneous squamous cell carcinoma (cSCC) of the head and neck on survival outcomes is not well elucidated. To date, there is no systematic review performed on the role of END in cN0 disease for advanced cSCC. This s…

OBJECTIVE: This study aims to update the prognostic value of perineural invasion(PNI) in various subgroups of esophageal cancer patients. METHODS: We searched databases including PubMed, Scopus, Wiley, Web of Science, and Embase for full-text articles published in English on esophageal cancer related to PNI. The searc…

BACKGROUND: Previous meta-analyses on the mode of enteral nutrition in intensive care unit (ICU) have not explored whether the standard practice of continuous enteral feeding is superior to intermittent or bolus feeding among mechanically ventilated patients. Large feed volumes maybe one of the barriers for the use of…