5,003,322 papers found

Behçet's syndrome (BS) is a complex disease that shows important heterogeneity in clinical findings and physiopathology. Its treatment can be problematic as BS manifestations in different organs may respond differently to the same drug. The cornerstone of therapy for inducing remission is corticosteroids whereas i…

PURPOSE: Community Treatment Orders (CTOs) require outpatients to adhere to treatment and permit rapid hospitalisation when necessary. They have become a clinical and policy solution to repeated hospital readmissions despite some strong opposition and the contested nature of published evidence. In this article, we appr…

Research devoted to the development of therapeutic, behavioral interventions for substance use disorders (SUDs) that can be accessed and delivered via computer and mobile technologies has increased rapidly during the past decade. Numerous recent reviews of this literature have supported the efficacy of technology-based…

OBJECTIVE: To examine published overviews of systematic reviews in terms of descriptive and methodological characteristics. STUDY DESIGN AND SETTING: MEDLINE, Database of Abstracts of Reviews of Effects, the Cochrane Database of Systematic Reviews, and several Health Technology Assessment databases were searched for o…

BACKGROUND: Transudative pleural effusions due to pleuroperitoneal communication occur in 1.6-10% of patients receiving peritoneal dialysis (PD) and usually have overtly elevated glucose concentrations. METHODS: We report two cases of verified pleuroperitoneal communication with minimally elevated pleural fluid glucos…

AIM: Since 2007 we focused our attention as EJPRM to the best available clinical evidence as offered by the Cochrane Collaboration. Due to the absence of a specific Rehabilitation Group.only a Field exists), reviews of PRM interest are in different groups and not easy to find. Consequently, the EJPRM offer the service…

BACKGROUND: The use of complementary and alternative medicine (CAM) in paediatric populations is common yet, to date, there has been no synthesis of the evidence of its effectiveness in that population. This overview of systematic review evaluates the evidence for or against the effectiveness of CAM for any childhood c…

Signet ring cell carcinoma (SRCC) of the breast is a rare tumor that is classified into mucinous carcinoma and other tumors with abundant mucin as an independent subset and entity under the 2003 World Health Organization (WHO) classification of tumors of the breast. Pure form SRCC is very rare. To date, only a few case…

OBJECTIVES: It is possible for baseline imbalances to occur between treatment groups for one or more variables in a randomized controlled trial, although the identification and detection of baseline imbalances remain controversial. If trials with baseline imbalances are combined in a meta-analysis, then this may result…

BACKGROUND: Some reports have documented posterior fossa cysts resulting in syringomyelic obstruction of cerebrospinal fluid (CSF) flow caused by cyst displacement within the foramen magnum. Rarely the syringomyelia is caused by acquired Chiari malformation due to a retrocerebellar arachnoid cyst. OBJECTIVE: To report…

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of penetrating versus non-penetrating mesh fixation in adults receiving laparoscopic groin hernia repair.

BACKGROUND: Data extraction (DE) is a challenging step in systematic reviews (SRs). Complex SRs can involve multiple interventions and/or outcomes and encompass multiple research questions. Attempts have been made to clarify DE aspects focusing on the subsequent meta-analysis; there are, however, no guidelines for DE i…

BACKGROUND: Healthcare provision remains challenging leading to a focus on health service redesign including the development of nurse-led clinics. While there is a belief that nurse-led services positively impact on healthcare delivery, it is necessary to inform development through examination of the evidence. METHODS…

PURPOSE: Adolescent obesity is a powerful predictor of morbidity and mortality, yet amenable to modifiable behaviors. To accurately summarize the effects of behavioral interventions on changes in adolescent body mass index and/or weight status, we assessed existing systematic reviews for reporting transparency and meth…

BACKGROUND: Genetic susceptibility of lung cancer has been widely studied for Chinese population, and meta-analysis of candidate gene association studies has also been performed for those genes. However, the overall evidence has not been well recognized. OBJECTIVE: To investigate genetic association for the risk of lu…

OBJECTIVE: To characterize the conclusions and production of nonsystematic reviews about neuraminidase inhibitors relative to financial competing interests held by the authors. STUDY DESIGN AND SETTING: We searched for articles about neuraminidase inhibitors and influenza (January 2005 to April 2015), identifying nons…

OBJECTIVE: To analyze tools used to critically appraise primary studies included in systematic reviews (SRs) of time to diagnosis (TTD). STUDY DESIGN AND SETTING: We systematically searched MEDLINE via PubMed and Web of Science for SRs of TTD published up to the end of February 2015; we identified and characterized to…

OBJECTIVES: To examine how often a significant publication bias (PB) existed when the assessment of PB was not reported in systematic reviews. STUDY DESIGN AND SETTING: All systematic reviews with meta-analyses of interventions and risk/prognostic factors published in the general medical journals with the top 10 impac…

BACKGROUND: Systematic reviews (SRs) worldwide suffer from methodological deficiencies, potentially biasing intervention decisions, and Peruvian SRs are no exception. Evaluating SRs led by Peruvian researchers is a crucial step to enhance quality and transparency in decision-making and to identify topics where SRs are…

Multiple Sclerosis (MS) is one of the immune-mediated demyelinating disorders. Multiple components, including the environment and genetics, are possible factors in the pathogenesis of MS. Also, it can be said that infections are a key component of the host's response to MS development. Finally, we evaluated the relatio…