2,589 papers found

BACKGROUND: Complete mesocolic excision (CME) is advocated based on oncologic superiority, but not commonly performed in North America. Many data are case series with few comparative studies. Our aim was to perform a systematic review comparing outcomes between CME and non-CME colectomy. METHODS: A systematic review w…

CONTEXT: Patients with clinical stage I (CS I) seminoma testis with large primary tumours and/or rete testis invasion (RTI) might have an increased risk of relapse. In recent years, these risk factors have frequently been employed to decide on adjuvant treatment. OBJECTIVE: To systematically review the literature on t…

PURPOSE: Education leaders at the 2012 Academic Emergency Medicine Consensus Conference on education research proposed that dedicated postgraduate education scholarship fellowships (ESFs) might provide an effective model for developing future faculty as scholars. A formal needs assessment was performed to understand th…

Trimetazidine acts as an effective antianginal clinical agent by modulating cardiac energy metabolism. Recent published data support the hypothesis that trimetazidine selectively inhibits long-chain 3-ketoacyl CoA thiolase (LC 3-KAT), thereby reducing fatty acid oxidation resulting in clinical benefit. The aim of this…

BACKGROUND: Heart failure leads to adverse clinical and patient-reported outcomes. Its prevalence has increased markedly among adults aged 60 years and over. Transitional care interventions are recommended to address these issues; however, their effectiveness on health outcomes, particularly in older adults, remains li…

BACKGROUND: The global recommendations of continuing breastfeeding for two years and beyond are not being realised. Barriers to breastfeeding beyond the infancy age of one year continue to be seen globally despite the recognition that facilitating it could prevent 823,000 child and 98,000 parent deaths every year. The…

OBJECTIVE: To describe current percutaneous dilatational tracheostomy (PDT) practice across Australian and New Zealand (ANZ) intensive care units (ICUs), quantify perceived procedural exposure among intensivists and trainees, and evaluate perceptions of competency and training adequacy. DESIGN: Cross-sectional, anonym…

BACKGROUND: Penicillin allergy (PenA) labels are common and often do not represent true immune-mediated allergy, yet are not routinely assessed or tested in the ICU. With greater demand for effective antimicrobial stewardship, and growing support for non-allergist performed PenA assessment, enthusiasm for routine ICU-l…

OBJECTIVE: Endometrial cancer uncommonly presents at an advanced stage and little prospective evidence exists to guide the management thereof. We aimed to summarize the evidence about primary cytoreductive surgery in the treatment of advanced stage endometrial cancer. DATA SOURCES: MEDLINE, Embase, and Scopus database…

INTRODUCTION: Understanding which theories have been effectively applied in tobacco control efforts for sexual and gender minority (SGM) individuals will help identify constructs to incorporate into future tobacco control efforts aimed at reducing SGM tobacco disparities. This scoping review summarizes the use of theor…

OBJECTIVES: No head-to-head trials had been performed to estimate the relative effectiveness of poly ADP-ribose polymerase inhibitor (PARPi) and androgen receptor signaling inhibitor (ARSi) in the first-line treatment for metastatic castration-resistant prostate cancer (mCRPC). We aimed to perform a systematic review a…

BACKGROUND: Multidisciplinary treatment for head and neck carcinoma offers the best curative results but generates acute toxicities, which negatively affect both patients' quality of life and treatment compliance. Usually, the patient's clinical condition is recorded during scheduled, time-limited office visits and pat…

BACKGROUND: Esophageal, gastroesophageal, and gastric cancers are still among the leading causes of death worldwide. The introduction of immune checkpoint inhibitors (ICIs) has revolutionized the treatment strategy for several cancers. The combination of conventional chemotherapy with ICIs has been hypostatized to play…

BACKGROUND: Mammalian bites are a common presentation in emergency and primary healthcare facilities across the world. The World Health Organization recommends postponing the suturing of a bite wound but this has not been evaluated through a systematic review. OBJECTIVES: To assess the effects of primary closure compa…

OBJECTIVE: To determine the effects of laparoscopic radical prostatectomy (LRP), or robot-assisted radical prostatectomy (RARP) compared with open radical prostatectomy (ORP) in men with localized prostate cancer. MATERIALS AND METHODS: We performed a comprehensive search using multiple databases (CENTRAL, MEDLINE, EM…

BACKGROUND: Acute promyelocytic leukemia (APL) is an aggressive malignancy. Although recent advancements in therapy have improved outcomes, differing toxicity profiles remain. The optimal choice between all-trans retinoic acid plus arsenic trioxide (ATRA + ATO) and ATRA plus chemotherapy, in newly diagnos…

BACKGROUND: Remifentanil patient-controlled analgesia (PCA) has emerged as an important option for labour analgesia, particularly for women who are unable to receive neuraxial analgesia. Concerns about maternal safety and staffing requirements suggest that in many maternity units, it is only infrequently used, leading…

BACKGROUND: Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD ranges from 1.5% to 9%, depending on latitude. The predictable seasonal aspect of SAD provides a promising opportunity…

BACKGROUND: Epilepsy is a common neurological condition characterised by recurrent seizures. Sulthiame (STM) is widely used as an antiepileptic drug in Europe and Israel. In this review, we present a summary of evidence for the use of STM as monotherapy in epilepsy. OBJECTIVES: To examine the efficacy and side effect…

Nutrition in sports, as a branch of nutritional science, is a constantly developing field with a growing number of scientific researches and recommendations concerning the justification of the diet composition to ensure the requirements for macro- and micronutrients of the athlete's body at different stages of sports a…