2,528 papers found

PURPOSE: A variety of techniques and materials have been used to establish the structural base of osseous tissue for supporting dental implants. The aim of this systematic review was to identify the most successful technique(s) to provide the necessary alveolar bone to place a dental implant and support long-term survi…

IMPORTANCE: Recurrent/metastatic adenoid cystic carcinoma (R/M AdCC) presents a clinical challenge with limited treatment options, particularly in the face of unsatisfactory efficacy from current therapeutic approaches. This review underscores the unmet clinical needs in managing R/M AdCC, emphasising the imperative fo…

To conduct a systematic review of the literature regarding rates and predictors of favorable seizure outcome after resective surgery for epileptic spasms (ES) in pediatric patients. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards were followed. We searched PubMed, EMBASE, and Cochrane C…

Etanercept (ETN) is a disease-modifying anti-rheumatic drug (DMARD) used in the treatment of rheumatoid arthritis (RA) that works as a tumor necrosis factor inhibitor (TNF inhibitor) by blocking the effects of naturally occurring TNF. This review will evaluate the effect of ETN as a monotherapy or combination ther…

INTRODUCTION: Human adult dental pulp stem cells (hDPSC) and stem cells from human exfoliated deciduous teeth (SHED) hold promise in bone regeneration for their easy accessibility, high proliferation rate, self-renewal and osteogenic differentiation capacity. Various organic and inorganic scaffold materials were pre-se…

BACKGROUND: acute myocardial infarction (AMI), ischemic heart diseases (IHDs) and stroke are serious cardiovascular diseases (CVDs) which may lead to hospitalizations, require periodical medical monitoring and life-long drugs use, thus having a high impact on public health and Healthcare Service expenditure. In this co…

CONTEXT: Management of men with penile squamous cell carcinoma (PSCC) who have high-risk features following radical inguinal lymphadenectomy (ILND) remains controversial. European Association of Urology guidelines state that adjuvant inguinal radiotherapy (AIRT) is "not generally recommended". Despite this, many centre…

AIM: This study aims to present a comprehensive international analysis of the existing techniques used in liquid biopsies and their use in isolating tumor markers to detect, predict, and monitor the results of cancer treatment. MATERIALS AND METHODS: We conducted a narrative review using a scoping review model based o…

There is a significant increase in the need for an efficient screening method that might identify cancer at an early stage and could improve patients' long-term survival due to the continued rise in cancer incidence and associated mortality. One such effort involved using circulating tumor DNA (ctDNA) as a rescue agent…

To compare the long-term outcomes of intersphincteric (trans-internal and external) sphincter resection (ISR) and abdominoperineal proctocolectomy (APR) for low-grade rectal cancer.We used a meta-analytic approach to compare these procedures . Published reports comparing ISR and APR for low rectal cancer in Pubmed, Med…

BACKGROUND: The unequal representation of women in global health leadership is a prevalent issue laterally across global health fields and vertically down experience levels. Although women compose much of the workforce, gender-based barriers prevent female talent from filling their appropriate leadership roles, which f…

IMPORTANCE: The identification and validation of biomarkers in hidradenitis suppurativa (HS) has potential to improve the understanding and management of this chronic, burdensome disease. OBJECTIVE: To systematically identify all known HS biomarkers, categorize them by biomarker type, and critically evaluate their val…

BACKGROUND: The activity of PD-1/PD-L1 inhibitors in the treatment of advanced bladder cancer (BC) is promising for many patients. However, a subset of patients do not benefit from treatment, thus leading to an effort to better identify predictive molecular biomarkers of response. OBJECTIVE: To conduct a systematic re…

OBJECTIVES: Maxillofacial reconstruction using microvascular free flaps is a well-established procedure to restore facial defects across various patients. Elderly patients face increased perioperative risks due to higher prevalence of comorbidities. This study aims to evaluate the characteristics of patients aged&#x200…

BACKGROUND: This is an update of the original Cochrane Review published in Cochrane Library, Issue 10, 2012.Hydatidiform mole (HM), also called a molar pregnancy, is characterised by an overgrowth of foetal chorionic tissue within the uterus. HMs may be partial (PM) or complete (CM) depending on their gross appearance,…

BACKGROUND: There is evidence that family and friends influence children's decisions to smoke. OBJECTIVES: To assess the effectiveness of interventions to help families stop children starting smoking. SEARCH METHODS: We searched 14 electronic bibliographic databases, including the Cochrane Tobacco Addiction Group spe…

Generative models based on diffusion and flow matching have recently been applied to structure-based drug design, but their outputs often include unrealistic protein-ligand interactions that do not obey the laws of physics. We present an energy guidance framework that incorporates a molecular mechanics force field (MMF…

BACKGROUND AND OBJECTIVES: Ischemic stroke (IS) is responsible for major causes of global death and disability, for which promoting angiogenesis is a promising therapeutic strategy. This study analyzed circular RNA PDS5B (circPDS5B) and its related mechanisms in angiogenesis in IS. METHODS: In the permanent middle cer…

BACKGROUND: Computed tomography (CT) reports for patients with bone metastases include key clinical details, but they are usually written as free text. Different doctors write reports in different ways, which makes it hard to extract information in a consistent way. Large language models (LLMs) may help pull out import…

OBJECTIVE: To characterize important patterns of genetic testing behavior and reporting in modern electronic medical records (EMRs) at the institutional level. MATERIALS AND METHODS: Retrospective observational study using EMR data of all 10,715 patients who received genetic testing by physicians trained in a primary…