5,083,489 papers found

Economic analyses can provide valuable information for health care decision makers. Systematic reviews of economic analyses can integrate information from multiple studies and provide important insights by systematically examining how differences between models lead to different results. We use our experience in develo…

STUDY DESIGN: Postal questionnaire survey. OBJECTIVE: To examine the current use of hormone replacement therapy (HRT) in a sample of menopausal women with spinal cord injury (SCI). SETTING: National Spinal Injuries Centre (NSIC), Stoke Mandeville Hospital, Aylesbury, UK. METHOD: A postal questionnaire was sent to 94…

Methods for systematic reviews are well developed for trials, but not for non-experimental or qualitative research. This paper describes the methods developed for reviewing research on people's perspectives and experiences ("views" studies) alongside trials within a series of reviews on young people's mental health, ph…

AIMS/HYPOTHESIS: Weight reduction is fundamental for type 2 diabetes management and remission, but uncertainty exists over which diet type is best to achieve and maintain weight loss. We evaluated dietary approaches for weight loss, and remission, in people with type 2 diabetes to inform practice and clinical guideline…

A review of standardized fetal heart rate (FHR) monitoring definitions and interpretation. Evidence suggests that standardization of intrapartum management can reduce adverse outcomes and professional liability claims. However, standardization of FHR monitoring has been impeded by a lack of consensus on standard defini…

This review discusses suicide warning signs in clinical practice and has three simple goals: 1) to help practitioners differentiate in a clinically meaningful fashion between warning signs and risk factors for suicide; 2) to articulate the link among warning signs for suicide, hopelessness, and intent to die; and 3) to…

An overview of the effort of nursing in translation research begins with studies in research utilization. Delineation of issues in the uptake of evidence using guidelines and systematic reviews is discussed next. The federal initiatives in translation research are described with a focus on the Translating Research Into…

Randomized, controlled trials (RCTs) are firmly established as the standard for determining which medical treatments are effective. In some areas of health care, however, among them surgery, public health, and the organization of health care delivery, most evidence addressing the effectiveness of clinical or policy int…

Optimal search strategies for the identification of publications on aetiological research are currently not available. The definition of adequate selection criteria is necessary to limit the harvest to a relevant and homogeneous set of publications. Yet, the harvest should be high in order to prevent many relevant pape…

A myriad of multisystem disorders may result from primary malignant disease, metastasis, or treatment. Neoplastic pericardial disease in the form of malignant effusions, tamponade, and pericarditis are not uncommonly seen. Compromise of blood return to the right side of the heart due to the superior vena cava syndrome…

Recent work on the biosynthesis of the tropane moiety of cocaine, hyoscamine, scopolamine, and related alkaloids is reviewed. Revision of the generally accepted biosynthetic pathway to these alkaloids is now proposed in the light of new discoveries. New information on the biosynthesis of some of the acid moieties (benz…

OBJECTIVES: Although the repair of partially defective resin composite restorations is promoted as a minimally invasive alternative to full replacement, existing evidence remains fragmented across systematic reviews with differing scopes and conclusions. This umbrella review synthesized current systematic reviews on th…

This umbrella review assessed evidence from systematic reviews (SRs) and meta-analyses (MAs) on the effects of tomato-derived lycopene on cardiovascular risk factors. A comprehensive search was conducted on April 8, 2025, across PubMed, Scopus, and ScienceOn. Eligible studies were SR/MAs of intervention studies involvi…

OBJECTIVE: This study emphasizes the general relevance of sleep disorders (SD) and temporomandibular disorders (TMD), explores their bidirectional relationship, and describes the importance of systematic reviews in the critical analysis of the literature. This review aimed to comprehensively summarize the relationship…

OBJECTIVE: To assess the effect of intravenous ketamine on postoperative pain control, opioid consumption, and the incidence of postoperative adverse events in gynaecological surgeries. METHODS: The systematic review and meta-analysis were conducted in July 2020 and the search was repeated in July 2021 to ensure accur…

PURPOSE: To summarize the more robust evidence about the performance of tools useful for diagnosis of medullary thyroid carcinoma (MTC) such as calcitonin (Ctn) and other circulating markers, ultrasound (US), fine-needle aspiration (FNA), and other imaging procedures. METHODS: This systematic review of systematic revi…

RespiCardia remedē System (Minnetonka, MN 2017), a transvenous phrenic nerve stimulator, is indicated to treat central sleep apnea (CSA) by stimulating the phrenic nerve to cause diaphragmatic contraction to restore normal breathing during sleep. CSA is associated with decreased patient quality of life and worsen…

PURPOSE: To review diverse tests that could serve as a screening tool for the dental community to identify patients with potential COVID-19. METHODS: Detailed automated searches of Medline, PubMed and EBM Review, including ACP Journal Club, the Cochrane Controlled Trials Register, and the Cochrane Database of Systemat…