391,885 papers found

A linear regression model derived from a meta-analysis of 13 epidemiological studies of senile dementia conducted since 1980, and employing internationally-known case-finding procedures, suggests a much lower general rate of dementia prevalence than has been previously estimated. An exponential increase with age is obs…

BACKGROUND: Cancers of the oesophagus, gastroesophageal junction (GEJ), and proximal stomach share epidemiological, molecular, and therapeutic characteristics. Despite their similarities, treatment guidelines vary, and the classification of GEJ tumours remains debated. While multiple meta-analyses have addressed subset…

INTRODUCTION: The promise of faster, simpler restorations has driven the rise of bulk-fill composites, but do speed and simplicity come at the cost of longevity and marginal integrity? OBJECTIVE: To compare and rank the clinical performance of bulk-fill and conventional incremental layering restoration techniques in C…

OBJECTIVE: To evaluate the efficacy of manifold ovarian stimulation protocols for patients with poor ovarian response. METHODS: PubMed, Embase, Cochrane Library and Web of Science were systematically searched until February 14, 2021. Primary outcomes included clinical pregnancy rate per initiating cycle and low risk o…

BACKGROUND CONTEXT: Nonspecific neck pain causes chronic pain, functional impairment, and adversely affects quality of life. It remains unclear whether exercise or other nonphysical therapies are more effective in improving nonspecific neck pain (NSNP), and the optimal dosage of exercise for alleviating NSNP has yet to…

This paper introduces the scope and rationale of The Collaborative Alcohol-Related Longitudinal Project and describes the individual longitudinal studies which contribute to this large collaborative project, representing studies from 15 countries. It also serves as an introduction to four reports of the preliminary fin…

BACKGROUND: Insomnia is a common problem after a stroke, affecting daily life and the recovery process. Among the many Traditional Chinese Medicine(TCM) nursing techniques, it is still unknown which measures are most effective. OBJECTIVE: To evaluate the efficacy of different TCM nursing techniques on post-stroke inso…

In a meta-analysis of placebo controlled NSAID trials, the sensitivity of the effect variables was calculated as the correlation coefficient and as the difference between drug and placebo, divided by the placebo group standard deviation. The patient's global evaluation was the most sensitive variable overall. Pain was…

Using a meta-analytic procedure we have analysed 16 studies employing a simple unimanual reaction time (RT) paradigm and lateralized visual stimuli to provide an estimate of interhemispheric transfer time in normal right-handed subjects. We found a significant overall RT advantage of the left visual field over the righ…

Epidemiological and experimental papers on respiratory effects of air pollution published between 1980 and 1988 were reviewed, using a meta-analytical approach. Forty epidemiological papers dealing with sulfur dioxide (SO2) and total suspended particles (TSP) were used to scrutinize the interaction between the two poll…

Reocclusion of infarct-related coronary arteries within 2 weeks of thrombolytic therapy varies from 5% to 45% and neither clinical nor angiographic variables have been proved to be predictive of reocclusion. The goal of the present study was to evaluate whether aspirin could prevent coronary reocclusion and recurrent i…

Despite several small comparative clinical trials, controversy persists over the best choice of antimicrobial therapy for penetrating abdominal trauma. Some still question whether single drug regimens are as effective as the traditional combinations containing an aminoglycoside. A meta-analysis was performed to address…

We have reviewed 185 articles published since 1966 to assess the scientific evidence for methods of treatment for lateral epicondylitis of the elbow. Of the 185 articles, 78 discussed treatment, but since the natural history of the syndrome is uncertain we considered only those series with concurrent control groups. On…

A hereditary disease with excess mortality such as haemophilia is maintained in the population by the occurrence of new cases, i.e. mutations. In haemophilia, mutations may arise in female or male ancestors of a 'new' patient. The ratio of the mutation frequencies in males over females determines the prior risk of carr…

The authors describe some situations where meta-analyses would have been of great benefit if they have been done or sufficiently published. They emphasize several problems ensued by this new method: if possible, meta-analyses have to be done each time a new trial is analysed, according to a precise method. Cumulative m…

To perform a meta-analysis of published reports in an attempt to determine the mean and range of normal ambulatory blood pressure (BP), 23 studies including a total of 3,476 normal subjects were reviewed. Most studies were compatible with a mean 24-hour BP in the range of 115 to 120/70 to 75 mm Hg, a mean daytime BP of…