386,595 papers found

A meta-analysis of published and unpublished studies was conducted to reconcile the apparent conflicting results in the domain of research designed to determine the effects of continuing education on nursing practice. The overall mean effect size supported the hypothesis that continuing education positively affects nur…

Establishing the overall efficacy or safety of a drug requires a unified methodological approach and analysis of all clinical trials that are intended to be summarized. As an example, this article presents the aggregated dose-response relationship and a subgroup analysis (by age) over all studies of the antihypertensiv…

UNLABELLED: BACKGROUND--The role of insulin in the genesis of essential hypertension remains an area of intense controversy. Most clinical evidence suggests a definite association. Several pathophysiologic mechanisms have been proposed. However, current data remain disparate and contradictory. METHODS--Meta-analysis al…

A review of research on the effects of met expectations for newcomers to organizations located 31 studies of 17,241 people. A meta-analysis found mean (corrected) correlations of .39 for job satisfaction and organizational commitment, .29 for intent to leave, .19 for job survival, and .11 for job performance. However,…

INTRODUCTION: Managing postoperative pain in patients following bariatric surgery is challenging. Although transversus abdominis plane block (TAPB) and erector spinae plane block (ESPB) have proved effective for pain relief, the analgesic efficacy between them remains controversial. This network meta-analysis was condu…

A linear regression model derived from a meta-analysis of 13 epidemiological studies of senile dementia conducted since 1980, and employing internationally-known case-finding procedures, suggests a much lower general rate of dementia prevalence than has been previously estimated. An exponential increase with age is obs…

The ability of prostaglandin E2 to prepare the unripe cervix before an indicated labor induction is controversial. We therefore tested 100 pregnant women in a randomized, double-blind trial with intracervical prostaglandin E2 gel, 0.5 mg. The 53 women who received the placebo gel had an outcome similar to that of the 4…

INTRODUCTION: The promise of faster, simpler restorations has driven the rise of bulk-fill composites, but do speed and simplicity come at the cost of longevity and marginal integrity? OBJECTIVE: To compare and rank the clinical performance of bulk-fill and conventional incremental layering restoration techniques in C…

BACKGROUND: India bears a heavy burden of iron deficiency anemia (IDA), affecting nearly 50% of the population and contributing to adverse pregnancy outcomes, accounting for 20% of maternal deaths. While IDA continues to be a major health issue in India, there is a lack of comparative data on the efficacy of Ayurvedic…

BACKGROUND: To comprehensively evaluate the biomechanical properties of traditional and emerging fixation configurations for pediatric supracondylar humerus fractures through experimental testing and network meta-analysis (NMA). METHODS: The study consisted of 2 parts: (1) A biomechanical comparison of 5 fixation conf…

The technique of meta-analysis was used to derive typical estimates of the risk of congenital malformations from oral contraceptive (OC) exposure in early pregnancy. Several definitions were used for non-exposure to reduce bias from this source. Congenital heart defects and limb reduction defects were analyzed separate…

Meta-analysis was used to review the results of 25 studies that compared the classroom behavior of children and adolescents with learning disabilities (LD) to children without learning disabilities. The data were analyzed from several different methodological perspectives. Results showed that both methodologically stro…

This paper introduces the scope and rationale of The Collaborative Alcohol-Related Longitudinal Project and describes the individual longitudinal studies which contribute to this large collaborative project, representing studies from 15 countries. It also serves as an introduction to four reports of the preliminary fin…

Model-based meta-analysis (MBMA) utilizes aggregate data (AD) and allows integration of information from multiple studies, which may provide more statistical power to detect clinically relevant treatment effects than an individual randomized controlled trial alone. Access to individual patient data (IPD) is often limit…

The cesarean birth rate has continued to climb despite efforts to counteract it. A major reason for this rise is the practice of elective repeat cesarean. We conducted a meta-analysis that included 31 studies with a total of 11,417 trials of labor to evaluate the association between birth route after a cesarean and mor…

Despite several small comparative clinical trials, controversy persists over the best choice of antimicrobial therapy for penetrating abdominal trauma. Some still question whether single drug regimens are as effective as the traditional combinations containing an aminoglycoside. A meta-analysis was performed to address…