381,523 papers found

BACKGROUND: Since the results obtained in controlled studies of antiviral treatment of chronic hepatitis by the hepatitis B virus are frequently insignificant the authors have undertaken a combined study of the different controlled trials with the meta-analysis technique. METHODS: The results of 7 controlled trials of…

PURPOSE: To evaluate the effects of various cleaning methods on the bond strength between lithium disilicate (LS) ceramics and resin cement under short- and long-term aging conditions using network meta-analysis (NMA) and pairwise meta-analysis (PMA). STUDY SELECTION: An electronic search of seven databases (PubMed, S…

In this meta-analysis it was demonstrated that, when compared with nonsmokers of similar age, smokers in the 8- to 19-year-old age group have significantly higher serum levels of triglyceride (+11.8%), very-low-density lipoprotein (VLDL)-cholesterol (+12.4%) and low-density lipoprotein (LDL)-cholesterol (+4.1%) and sig…

Beta-Adrenergic blockers have been considered relatively contraindicated in peripheral arterial disease because of the perceived risk that these drugs could worsen intermittent claudication. Therefore, we conducted a meta-analysis of available randomized controlled trials from the English-language literature to determi…

OBJECTIVE: To perform a meta-analysis on studies evaluating the effect of angiotensin-converting enzyme (ACE) inhibitors on diabetic nephropathy in patients with type 2 diabetes mellitus. METHODS: A computerized literature search was conducted for articles of studies comparing ACE inhibitors with a control in patients…

A meta-analysis of published and unpublished studies was conducted to reconcile the apparent conflicting results in the domain of research designed to determine the effects of continuing education on nursing practice. The overall mean effect size supported the hypothesis that continuing education positively affects nur…

Methods of meta-analysis, computer modeling, and issue analysis are used to answer four key questions related to efficacy, cost, and political feasibility of legislating insurance coverage for mammography. The findings are presented, and the strengths and weaknesses of the combined use of these methods to inform policy…

This meta-analysis is based on 106 evaluations of response from 77 clinical studies about 5-fluorouracil (5FU) treatment with or without leucovorin (LV) in metastatic colorectal carcinoma. Overall, in naive patients, LV is associated with a median response rate of 31% as compared with a 12% figure with 5FU alone. Using…

In a review of 19 clinically relevant comparative outcome studies published 1978-1988, short-term psychodynamic psychotherapy (STPP) was evaluated as to overall effects, differential effects, and moderating effects vis-à-vis no-treatment controls (NT) and alternative psychotherapies (AP), respectively. Overall, ST…

The cesarean birth rate has continued to climb despite efforts to counteract it. A major reason for this rise is the practice of elective repeat cesarean. We conducted a meta-analysis that included 31 studies with a total of 11,417 trials of labor to evaluate the association between birth route after a cesarean and mor…

Establishing the overall efficacy or safety of a drug requires a unified methodological approach and analysis of all clinical trials that are intended to be summarized. As an example, this article presents the aggregated dose-response relationship and a subgroup analysis (by age) over all studies of the antihypertensiv…

UNLABELLED: BACKGROUND--The role of insulin in the genesis of essential hypertension remains an area of intense controversy. Most clinical evidence suggests a definite association. Several pathophysiologic mechanisms have been proposed. However, current data remain disparate and contradictory. METHODS--Meta-analysis al…

A review of research on the effects of met expectations for newcomers to organizations located 31 studies of 17,241 people. A meta-analysis found mean (corrected) correlations of .39 for job satisfaction and organizational commitment, .29 for intent to leave, .19 for job survival, and .11 for job performance. However,…

Size and stability of sex differences in personality growth throughout adolescence and adulthood are examined. Studies using the Washington University Sentence Completion Test of ego development served as the primary source data. Sixty-five studies (encompassing more than 9,000 Ss) generated 113 independent effect size…

PURPOSE: Remote-access thyroidectomy techniques and minimally invasive video-assisted thyroidectomy (MIVAT) have been developed to optimize cosmetic outcomes and potentially improve recovery, particularly in the case of MIVAT, compared with the conventional transcervical approach (CTA). However, comparative evidence re…

A linear regression model derived from a meta-analysis of 13 epidemiological studies of senile dementia conducted since 1980, and employing internationally-known case-finding procedures, suggests a much lower general rate of dementia prevalence than has been previously estimated. An exponential increase with age is obs…

INTRODUCTION: Artificial intelligence (AI), particularly large-language models like Chat Generative Pre-Trained Transformer (ChatGPT), has demonstrated potential in streamlining research methodologies. Systematic reviews and meta-analyses, often considered the pinnacle of evidence-based medicine, are inherently time-in…