2,693 papers found

Targeted therapies, such as the CDC25B inhibitor menadione, have shown promise in treating gastric cancer (GC). Circulating tumor cells (CTCs) are emerging as a tool for monitoring treatment efficacy. This study aims to assess the impact of CTC counts on treatment outcomes and the efficacy of menadione in GC. This anal…

We identified 3910 elderly (>65 yrs) patients with diffuse large B-cell lymphoma (DLBCL) who received doxorubicin-based (+/-rituximab) therapy and 77 347 cancer-free controls, and assessed cardiovascular events and survival in relation to preexisting cardiovascular comorbidities. Compared to controls, patients with DLB…

BACKGROUND: Managing chronic wounds, particularly pressure injuries, poses a challenge for healthcare professionals. This study aimed to evaluate the effectiveness of Iranian sheep-felt mattresses in preventing pressure injuries among hospitalized patients. METHODS: In this parallel, open-label randomized controlled tr…

PURPOSE: Metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease with current standard-of-care therapies. Homologous recombination repair (HRR) gene alterations, includingalterations, can sensitize cancer cells to poly (ADP-ribose) polymerase inhibition, which may improve outcomes in treatment-…

: The overnight 1-mg dexamethasone suppression test (DST) represents the conventional/standard tool for endogenous hypercortisolemia screening, typically in relationship with adrenal and pituitary masses. Nevertheless, an associated spectrum of challenges and pitfalls is found in daily practice. This analysis aimed to…

BACKGROUND: Numerous medications are available for the acute treatment of migraine in adults, and some have now been approved for use in children and adolescents in the ambulatory setting. A systematic review of acute treatment of migraine medication trials in children and adolescents will help clinicians make evidence…

BACKGROUND: High altitude illness (HAI) is a term used to describe a group of cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (8202 feet). Acute hypoxia, acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are report…

BACKGROUND: Endometrial cancer is the sixth most common cancer in women worldwide and most commonly occurs after the menopause (75%) (globocan.iarc.fr). About 319,000 new cases were diagnosed worldwide in 2012. Endometrial cancer is commonly considered as a potentially 'curable cancer,' as approximately 75% of cases ar…

BACKGROUND: Autologous stem cell transplantation is widely used to restore functioning bone marrow in people with malignant lymphoma or multiple myeloma after myeloablative chemotherapy. Results of some clinical trials indicate that plerixafor in addition to granulocyte colony-stimulating factors (G-CSF) compared to G-…

The objective of this study is to assess whether family presence or engagement during PICU rehabilitation is associated with improved child mobility or function, and to identify evidence for structured family-delivered physiotherapy. PRISMA 2020-compliant systematic review of six databases (2000-March 2026) i…

BACKGROUND: Dipeptidyl peptidase 4 (DPP-4; also known as CD26), a transmembrane receptor expressed on T cells, has a costimulatory function in activating T cells. In a mouse model, down-regulation of CD26 prevented graft-versus-host disease (GVHD) but preserved graft-versus-tumor effects. Whether inhibition of DPP-4 wi…

BACKGROUND: Ovarian cancer is the seventh most frequent cancer diagnosis worldwide, and the eighth leading cause of cancer mortality. Epithelial ovarian cancer is the most common kind, accounting for 90% of cases. First-line therapy for women with epithelial ovarian cancer consists of a combination of cytoreductive sur…

BACKGROUND: Common fetal aneuploidies include Down syndrome (trisomy 21 or T21), Edward syndrome (trisomy 18 or T18), Patau syndrome (trisomy 13 or T13), Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Triple X syndrome (47,XXX) and 47,XYY syndrome (47,XYY). Prenatal screening for fetal aneuploidies is standard…

UNLABELLED: The rapid evolution of generative and diffusion-based method in artificial intelligence (AI) has transformedpeptide and protein design, enabling the creation of sequence–structure–function relationships beyond conventional heuristic exploration. In this work, we developed an AI-guided molecula…

PURPOSE: Determining the optimal timing of surgery for Crohn disease (CD) is challenging. The C-reactive protein-to-albumin ratio (CAR) is inexpensive and widely available; however, its utility in determining surgical timing remains unclear. METHODS: We retrospectively analyzed 112 cases of penetrating-type CD resecti…

OBJECTIVES: This study evaluated the effect of soy-based and milk-based yogurts against enamel erosive-abrasive surface loss. MATERIALS AND METHODS: Ninety-eight bovine enamel specimens were randomly allocated to seven experimental groups (n = 14). Over seven days, specimens underwent six daily erosive c…

OBJECTIVE: To evaluate the real-world effectiveness and safety of adjunctive zonisamide in children with developmental epileptic encephalopathy/epileptic encephalopathy (DEE/EE), focusing on younger children and highly drug-resistant cases. METHODS: This open-label, nonrandomized, self-controlled, real-world study inc…

PURPOSE: Malignant transformation (MT) is the principal driver of mortality in lower-grade glioma (LGG), yet its preoperative determinants and timing remain poorly defined. We quantified imaging elements of MT and its timing, correcting for bias in dating transformation. METHODS: We evaluated contrast enhancement (CE)…

BACKGROUND: Post-neoadjuvant circulating tumor DNA (ctDNA) has been investigated as a minimal residual disease (MRD) marker in stage I-III triple-negative breast cancer (TNBC), but landmark timing and assay approaches vary. OBJECTIVES: To assess whether post-neoadjuvant and/or peri-operative ctDNA MRD positivity is as…

BACKGROUND: Emergency care treatment plans provide recommendations about treatment, including cardiopulmonary resuscitation, to be considered in emergency medical situations. In 2016, the Resuscitation Council United Kingdom developed a standardised emergency care treatment plan, the recommended summary plan for emerge…