44,707 papers found

OBJECTIVE: To identify, describe, and evaluate interventions to reduce unnecessary central venous catheter (CVC) use to prevent central-line-associated bloodstream infections (CLABSIs) in adults. DESIGN: Systematic review. METHODS: The review has been registered in PROSPERO, an international prospective register of s…

Although biologically known for its central role in calcium homeostasis, Vitamin D3 (VD3), owing to its scattered receptors across bodily tissues and the presence of its metabolizing enzymes, has recently garnered scientific attention. This review examined the literature to document the role and specific mechanisms of…

OBJECTIVE: To share with clinicians supporting evidence of the safest and the most effective processes for central venous catheter insertion and maintenance as a strategy to prevent catheter-associated bloodstream infections. METHODS: A literature search was conducted in the Medline via PubMed, Embase Central and Lila…

BACKGROUND: Uncaria rhynchophylla (Miq.) Jacks (Rubinaceae), a common herbal medicine known as Gou-teng in Chinese, is commonly used in Chinese medicine practice for the treatment of convulsions, hypertension, epilepsy, eclampsia and other cerebral diseases. The major active components of U. rhynchophylla are alkaloids…

BACKGROUND: The Baveno VII consensus formally defined cirrhosis recompensation in 2022, marking an important milestone in the transition of cirrhosis management from complication control toward disease modification. This concept did not emerge abruptly but was built on decades of research concerning etiological control…

BACKGROUND: Development of cancer of the cervix is a multi-step process as before cervical cancer develops, cervical cells undergo changes and become abnormal. These abnormalities are called cervical intraepithelial neoplasia (CIN) and are associated with increased risk of subsequent invasive cancer of the cervix. Onco…

INTRODUCTION: Laboratory Quality Management Systems (LQMS) are fundamental to reliable diagnostic services and improved patient outcomes. Although Nigeria has made progress through quality improvement initiatives, implementation of internationally recognized standards remains limited. This review critically examines th…

BACKGROUND: We performed a systematic review that identified at least 9,000 scientific papers on PubMed that include immunofluorescent images of cells from the central nervous system (CNS). These CNS papers contain tens of thousands of immunofluorescent neural images supporting the findings of over 50,000 associated re…

BACKGROUND: As Huntington's disease (HD) is a progressive disease for which there is no cure yet, patients in the advanced stage of HD may benefit from palliative care. OBJECTIVE: To review the literature focusing on palliative care in advanced stage HD, and the level of evidence. METHODS: Publications between 1993 a…

Coronavirus disease 2019 (COVID-19) has rapidly spread across the globe since December 2019. The spectrum of clinical manifestations of COVID-19 ranges from mild to life-threatening forms. Alteration of hepatic function in COVID-19 is multifactorial. The objective of this systematic review is to assess the relationship…

OBJECTIVE: To assess the effectiveness of an intralesional injection of verapamil in men with Peyronie's disease (PD). MATERIALS AND METHODS: The data provided in the current review are based on a thorough review of the available original articles on PD retrieved with a systematic literature search using PubMed- Medli…

BACKGROUND: The type VI choledochal cyst of the cystic duct (CC-CD) is not only a taxonomical conundrum but also a matter of research in terms of its etiopathogenesis and optimal therapeutic options. The role of anomalous pancreaticobiliary junction (PBJ) and pancreatic juice regurgitation in the etiopathogenesis of CC…

BACKGROUND: Acute kidney injury (AKI) is a frequent and important complication of cardiac surgery. Decreased perfusion is a key mechanism. This decreased perfusion may be attenuated by intravenous amino acids (AAs) through recruitment of renal functional reserve. METHODS: The study investigators performed a PubMed sea…

BACKGROUND: Historically, epidemics have been accompanied by the concurrent emergence of stigma, prejudice, and xenophobia. This scoping review aimed to describe and map published research targeting ethical values concerning monkeypox (mpox). In addition, it aimed to understand the research gaps related to mpox associa…

Beall's list is widely used to identify potentially predatory journals. With this study, we aim to investigate the impact of Beall's list on the perception of listed journals as well as on the publication and citation behavior of the scientific community. We performed comprehensive bibliometric analyses of data extract…

AIM: To analyse the main characteristics of the top 50 most-cited articles published in the International Endodontic Journal from 1967 to 2018. METHODOLOGY: The Clarivate Analytics' Web of Science 'All Databases', Elsevier's Scopus, Google Scholar and PubMed Central were searched to retrieve the 50 most-cited articles…

Triple-negative breast cancer (TNBC), a unique subtype of breast cancer, which is resistant to endocrine and targeted therapy, usually relapses early, progresses rapidly and is associated with a poor prognosis. Epidemiological investigations focusing on the association between risk factors and the onset of TNBC demonst…

CCAAT/enhancer binding protein (C/EBP) β and C/EBPδ are transcription factors of the basic-leucine zipper class which share phylogenetic, structural and functional features. In this review we first describe in depth their basic molecular biology which includes fascinating aspects such as the regulated use o…

OBJECTIVE: This living systematic review aims to provide a timely, rigorous, and continuously updated summary of the evidence available on the role of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) in the treatment of patients with COVID-19. DATA SOURCES: We conducted search…

Virtual reality is increasingly used in neurorehabilitation because it provides interactive therapeutic experiences that can enhance patient engagement and support rehabilitation goals. Despite growing evidence supporting its potential benefits, the extent of its integration into routine clinical practice remains uncle…