5,083,489 papers found

Metastatic pancreatic cancer is rare, accounting for approximately 2% of all pancreatic malignancies, and most cases arise from renal cell carcinoma. We report the case of a 63-year-old woman, who presented with a pancreatic tumor detected during her annual health examination. She had undergone left nephrectomy 13 year…

This overview of reviews analyzes the impact of diet therapy in the treatment of overweight and obesity in children and adolescents 0-19 years of age. A literature search was conducted in the Cochrane Library, Medline, EMBASE, and ClinicalTrials.gov. Systematic reviews and meta-analyses of randomized controlled trials…

Consumption of different food groups is linked to a range of health outcomes. It is essential to integrate the most reliable evidence regarding intake of different food groups and risk of mortality to optimize dietary guidance. Our aim is to systematically and comprehensively assess the associations between the consump…

Air pollution, especially particulate matter (PM), is one of the most common risk factors for global burden of disease. However, its effect on the risk of digestive diseases is unclear. Herein, we attempt to explore this issue by reviewing the existing evidence from published meta-analyses. We conducted a systematic li…

OBJECTIVE: To summarize the evidence of various exercise modalities on population with insomnia disorders. METHOD: PubMed, Embase, Cochrane Library, and Web of Science were searched for eligible studies published from inception to October 2022 and updated on September 2023. Systematic reviews with meta-analyses and ra…

BACKGROUND: Changes in quantitative sensory testing (QST) after manual therapy can provide insight into pain relief mechanisms. Prior systematic reviews have evaluated manual-therapy-induced QST change. This overview of systematic reviews aims to consolidate this body of literature and critically review evidence on the…

INTRODUCTION: Dietary fat intake during pregnancy and childhood is important for health. However, several health aspects are inconclusive. METHODS: We systematically searched Medline, Cochrane Library, and Epistemonikos for systematic reviews (SRs) of randomized controlled trials (RCTs) and/or prospective cohort studi…

This study aims to summarize the effects of herbs on dementia and assess the strength of evidence. Six international and local databases were searched from inception to October 2021 for systematic reviews and meta-analyses of clinical trials investigated the effects of herbal medicine on dementia or cognitive function.…

BACKGROUND: Stroke is the prime cause of disability in the elderly population. Transcranial direct current stimulation (tDCS) is an emerging noninvasive brain stimulation in rehabilitating upper limb function post-stroke. However, mixed evidence exists in the literature and ambiguous conclusions regarding the effect of…

BACKGROUND: Evidence-to-decision (EtD) frameworks provide a structured and transparent approach for groups of experts to use when formulating recommendations or making decisions. While extensively used for clinical and public health recommendations, EtD frameworks are not in widespread use in environmental health. This…

INTRODUCTION: The treatment of an anterior cruciate ligament rupture is still controversial. In particular, this applies to the question of conservative versus surgical treatment. The answer to this question is often based on consequential damage such as the development of posttraumatic osteoarthritis, secondary damage…

PROBLEM: Adolescents and young adults with chronic illnesses continue to face barriers as they transition from pediatric to adult care. An evidence map can help to identify gaps in the transition literature to determine targets for future research. ELIGIBILITY CRITERIA: We searched PubMed, CINAHL, PsycInfo, and Cochra…

OBJECTIVE: This article aims to assess systematic reviews and/or meta-analyses on calcium-based caries preventive agents, evaluating reported evidence, thereby summarizing a critical appraisal on the subject. MATERIALS AND METHODS: A systematic search was done using PubMed, Cochrane Library, and Web of Science. System…

OBJECTIVES: Systematic reviews should provide balanced assessments of benefits and harms, while focusing on the most important outcomes. Selection of harms to be reviewed can be a challenge due to the potential for large numbers of diverse harms. STUDY DESIGN AND SETTING: A workgroup of methodologists from Evidence-ba…

Sarcopenia-progressive age-related loss of muscle mass and function-substantially elevates fall susceptibility among older adults. While exercise and nutritional interventions have been studied separately for either sarcopenia management or fall prevention, no comprehensive synthesis has evaluated the convergence of th…

BACKGROUND: Dietary fats may influence carcinogenesis through pathways involving lipid metabolism, oxidative stress, and inflammation. However, existing evidence from meta-analyses (MAs) remains inconsistent across cancer types. OBJECTIVES: We conducted an umbrella review and updated the MA to evaluate the association…

BACKGROUND: Exercise interventions are essential for maintaining functional independence in older adults, with systematic reviews guiding evidence-based practice. However, implementing these interventions requires detailed information about exercise parameters, progression strategies, and contextual adaptations that ex…

The available evidence on the effects of ambient air pollution on cardiovascular diseases (CVDs) has increased substantially. In this umbrella review, we summarized the current epidemiological evidence from systematic reviews and meta-analyses linking ambient air pollution and CVDs, with a focus on geographical differe…

BACKGROUND: Handheld computers and mobile devices provide instant access to vast amounts and types of useful information for health care professionals. Their reduced size and increased processing speed has led to rapid adoption in health care. Thus, it is important to identify whether handheld computers are actually ef…