98,317 papers found

Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the p…

An academic family physician reflects on 30 years of night call on the very last night of call. The experiences of the drive to the hospital, interactions with resident physicians, and caring for patients through the "neglected hours of the day" blend together in the narratives of patients. Night call is an essential a…

Several reports indicate an ongoing increase in the incidence, prevalence and severity of atopic diseases both in industrialized and developing countries. This prevalence is steadily increasing mainly in the last 20 years. Babies of atopic parents are particularly prone to develop atopic diseases, and for this reason t…

This is a retrospective review of 7398 deliveries under the direct care of the author over 25 years, from data input on personal handheld computers at the time of delivery. A more detailed look at 409 deliveries over 2.5 years where all the case notes were studied was also undertaken. The rate of cesarean…

A very rare combination of two rare entities is reported. The patient had anterior sacral and intrasacral meningoceles, which were repaired at age 3 years, and 7 years later he presented with hypopituitarism due to a suprasellar teratocarcinoma. There has been no evidence of tumor recurrence in the 2.5 years since subt…

The management of advanced gastric cancer has only evolved a little over the last 15 years: platinum and fluoropyrimidine chemotherapy remains the backbone of therapy with ongoing debate as to the benefit of triplet therapy with either an anthracycline or taxane. Recently published trials of biological agents, in parti…

During the last years the diagnosis and treatment of pyogenic liver abscess has changed substantially. The aim of this work is to report a retrospective analysis of 50 patients aged 24 to 87 years old, that presented with a pyogenic liver abscess and were treated in the last 13 years. The sensitivity for diagnosis of u…

Leprosy control started in a limited area of Ethiopia in 1956. Extended coverage of the country was achieved in the early seventies. Review of the data from the control projects since 1976 revealed that leprosy is a disease of the Ethiopian highlands where prevalence rates as high as 7 per thousand have been recorded i…

OBJECTIVE: To evaluate the long-term safety and effectiveness of tadalafil in pediatric patients with pulmonary arterial hypertension (PAH) in real-world clinical practice. METHODS: This is an observational surveillance of PAH patients receiving tadalafil in the contracted sites. A sub-group analysis was performed of…

The argon laser is a useful instrument that, during the last 5 years, has become a widely accepted and available tool in cutaneous surgery. Its primary use is in the treatment of various cutaneous lesions, although it also produces very satisfactory results when applied to professional decorative tattoos. These procedu…

BACKGROUND AND AIM: Membranous subaortic stenosis is a CHD with high recurrence-rate despite surgical treatment. This study investigated the outcome of operated patients and possible predictors for recurrence. METHODS: Retrospective review of all patients (= 38) ≤ 18 years of age operated for membranous subaort…

A study of 207 consecutive white patients older than 18 years of age with nonfamilial nodular and superficial spreading melanoma and 295 controls was conducted in southeast France. Controls were recruited in a public health center. They were matched for sex and age to the overall population older than 18 years of age a…

During 16 years operations were performed on 423 patients with peptic ulcers of anastomoses, in 13 of them the disease was complicated by gastro-intestinal-colonic fistulas. Of 7 patients operated upon during first 11 years four patients died, of 6 patients operated upon during the second period (the last 5 years) ther…

BACKGROUND: In a prospective observational study of 42 pregnancies in 39 Caucasian women (age 30 +/- 4 years) with polycystic ovary syndrome (PCOS), we examined effects of metformin on maternal insulin, insulin resistance (IR), insulin secretion (IS), weight gain, development of gestational diabetes (GD), testosterone…

BACKGROUND: We previously identified that zoledronate administered at 18-month intervals reduced fragility fractures by a third in a 6-year trial of women older than 65 years with osteopenia. This extension aims to identify the persistence of these effects. METHODS: Of the 2000 ambulant, community dwelling, postmenopa…

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease and is clinically characterized by a series of motor symptoms (MS) and nonmotor symptoms (NMS). NMS often appear before MS, while cognitive impairment mostly occurs within a few years after the diagnosis of PD. Therefore, we aimed to predict the risk f…

BACKGROUND: In 1997, a survey in Kisumu found a prevalence of HIV infection among female sex workers (FSW) of 75%. Only 50% reported using a condom with the last client. In 2008, we conducted another survey to collect data to inform an intervention targeting FSW in Kisumu. METHODS: In 2008 FSW were recruited by respon…

BACKGROUND: Head and neck (HN) defects after tumor extirpation can be challenging to repair. Historically, pedicled flaps were the mainstay for reconstruction, but recently, free tissue transfer has been preferred. This study compares patient characteristics and flap outcomes for HN defects over a 30-year period at the…

Earlier workers have overlooked deep-sea bentonite beds when unraveling the Cenozoic volcanic history of an area. In the North Pacific, identification of Miocene and older volcanic episodes is possible only if both altered (bentonite) and unaltered ash beds are recognized. Our study, which includes bentonite beds, show…

OBJECTIVE: To evaluate prevalence and characteristics of cataracts in the Norwegian Buhund breed 20 years after high reported prevalence of especially pulverulent nuclear cataracts (PNCs). ANIMALS STUDIED: Two hundred and fifty Norwegian Buhund dogs in Norway, Sweden, and Denmark (117 males and 133 females) with previ…