Accurate confidence intervals for risk difference in meta-analysis with rare events.
Jiang Tao, Cao Baixin, Shan Guogen·BMC medical research methodology
BACKGROUND: Meta-analysis provides a useful statistical tool to effectively estimate treatment effect from multiple studies. When the outcome is binary and it is rare (e.g., safety data in clinical trials), the traditionally used methods may have unsatisfactory performance. METHODS: We propose using importance samplin…