375,956 papers found

BACKGROUND: While various endoscopic techniques are used for minimally invasive tissue sampling in suspected sarcoidosis, comprehensive evidence comparing their diagnostic efficacy is limited, and the optimal approach remains unclear. RESEARCH QUESTION: Which endoscopic technique provides the greatest diagnostic advan…

PURPOSE: Post-stroke cognitive impairment (PSCI) affects nearly half of stroke survivors, necessitating effective interventions. This Bayesian network meta-analysis evaluated the efficacy of various repetitive transcranial magnetic stimulation (rTMS) protocols for PSCI. METHODS: We systematically searched PubMed, Coch…

OBJECTIVE: To evaluate the efficacy of manifold ovarian stimulation protocols for patients with poor ovarian response. METHODS: PubMed, Embase, Cochrane Library and Web of Science were systematically searched until February 14, 2021. Primary outcomes included clinical pregnancy rate per initiating cycle and low risk o…

In a meta-analysis of placebo controlled NSAID trials, the sensitivity of the effect variables was calculated as the correlation coefficient and as the difference between drug and placebo, divided by the placebo group standard deviation. The patient's global evaluation was the most sensitive variable overall. Pain was…

PURPOSE: Nursing students exhibit a high prevalence of anxiety and depression, which negatively affect their well-being. This study aimed to compare the effects of various emotional management interventions to identify the optimal strategies for this population. METHODS: A systematic search of the Cochrane Library, Pr…

This paper introduces the scope and rationale of The Collaborative Alcohol-Related Longitudinal Project and describes the individual longitudinal studies which contribute to this large collaborative project, representing studies from 15 countries. It also serves as an introduction to four reports of the preliminary fin…

Digital CBT-I is efficacious for insomnia, but optimal intended dose and dose-response relationship are unclear. This study investigated the dose-response relationship and optimal dose of digital CBT-I for insomnia treatment. We included the randomized controlled trials (RCTs) investigating digital CBT-I and reporting…

BACKGROUND: Direct oral anticoagulants (DOACs) are increasingly preferred over vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF), including valvular (VAF) and non-valvular (NVAF). This network meta-analysis aimed to evaluate and compare the efficacy and safety of different DOACs versus VKAs…

Left ventricular hypertrophy (LVH) is an independent risk indicator of cardiovascular disease. Obtaining reversal of hypertension-induced cardiac hypertrophy seems to be a desirable objective of antihypertensive treatment. A total of 2,357 patients were included in a meta-analysis on the effect of antihypertensive phar…

OBJECTIVE: This study compared aerobic exercise (AE), resistance training (RT), high-intensity interval training (HIIT) and combined training (COM) on insulin resistance markers in children and adolescents with overweight/obesity via network meta-analysis (NMA). METHODS: Following PRISMA guidelines, 63 RCTs (n …

BACKGROUND: To comprehensively evaluate the biomechanical properties of traditional and emerging fixation configurations for pediatric supracondylar humerus fractures through experimental testing and network meta-analysis (NMA). METHODS: The study consisted of 2 parts: (1) A biomechanical comparison of 5 fixation conf…

Exercise interventions can effectively reduce blood pressure (BP), but the optimal exercise modality and dose remain unclear. This study aimed to compare the effects of different exercise modalities and doses on systolic and diastolic BP using Bayesian network meta-analysis and dose-response modeling. Randomized contro…

Using a meta-analytic procedure we have analysed 16 studies employing a simple unimanual reaction time (RT) paradigm and lateralized visual stimuli to provide an estimate of interhemispheric transfer time in normal right-handed subjects. We found a significant overall RT advantage of the left visual field over the righ…

BACKGROUND: This network meta-analysis (NMA) assessed the relative efficacy of airway warming devices and combined warming strategies for preventing intraoperative hypothermia. METHODS: We searched MEDLINE, EMBASE, CENTRAL, and Google Scholar to identify randomized controlled trials (RCTs) published through November 2…

Perinatal corticosteroids are like a double-edged sword. On the one hand, they reduce risk for major morbidity and even mortality; on the other hand, they modify growth and development of body systems, with short- and long-term consequences. The relationship between corticosteroids and neurodevelopmental outcome has be…