1,575,354 papers found

The effectiveness of the periodontal ligament injection in providing anesthesia for routine extractions and the possible mechanisms of action of the periodontal ligament injection in producing dental anesthesia were investigated in a clinical trial. Periodontal ligament injections were administered under strong pressur…

A 4-week double-blind controlled clinical trial was carried out in which fluspirilene, an injectable diphenylbutylpiperidine neuroleptic given weekly, was compared to chlorpromazine in the treatment of 40 newly admitted schizophrenic patients with acute exacerbation. Similar therapeutic improvement was obtained with bo…

This report draws attention to the wide use of the controlled clinical trial in the study of tuberculosis in certain countries and centres and to the remarkable neglect of this method in the great majority of countries. Its versatility has been demonstrated by many studies: it has been used to study not only alternativ…

A clinical trial using four different oral refeeding regimes was conducted in 100 patients following acute gastro-enteritis. There was no difference in terms of the diarrhoea-relapse rates among the four groups of patients. However, a better weight gain was recorded in the groups using a lactose-free soy formula and a…

Increasing mebendazole bioavailability is one of the most important problems to be solved in echinococcosis chemotherapy. The method of mebendazole administration with sunflower oil, elaborated by the authors, serves to this purpose: drug concentration exceeding the minimal effective one was attained in 86% patients tr…

A single, masked controlled clinical trial showed that vision therapy improved both the accuracy and repeatability of stereophotogrammetric performance on the profiling task with experienced, visually normal observers. The average fixation disparity measured under working conditions decreased and stereoscopic acuity as…

A 12-month clinical study of Duchenne muscular dystrophy was carried out during a double-blind trial of allopurinol therapy. The disease was monitored by assessment of muscle power and function, pulmonary function tests, and electrocardiography. Biochemical assessments were made of plasma creatine kinase, pyruvate kina…

In a double-blind factorial clinical trial in 300 patients (150 primiparae and 150 multiparae), the effects of amniotomy, rociverine, and butylscopolamine bromide administration on the course of labor were investigated. Rociverine significantly reduced the dilatation time and had no effect on the delivery time. Butylsc…

Preoperative radiotherapy vs postoperative radiotherapy in the management of patients with primary tumors of the hypopharynx was evaluated by a prospective, randomized clinical trial. A statistically significant difference (p less than 1%) existed in favor of postoperative radiotherapy relative to survival rates, compl…

The anorexigenic activity of a new compound tricyclic in nature and non-related to amphetamine, mazindol, was studied. The experiment was carried out in 20 patients (17 females and 3 males) aged 17-55 years with a minim overweight of 15% above ideal body weight. Simultaseously, another group of 20 patients (16 females…

The authors first remind some toxicological and some pharmacological properties of piracetam (Nootropil), then present the results of a test giving evidence of the presence of this drug in the cerebrospinal fluid after intravenous administration to man. In a double blind study, the activity of piracetam is tested on 31…

This study on the control of head lice infestation in Tasmania confirms the efficacy of malathion preparations compared with lindane preparations.