5,083,888 papers found

INTRODUCTION: Cancer is a major global health concern, and immune checkpoint inhibitors (ICIs) offer a promising treatment option for cancer patients. However, the efficacy of ICIs can be influenced by various factors, including the use of concomitant medications. METHODS: We searched databases (PubMed, Embase, Cochra…

BACKGROUND: The majority of people with a chronic disease (e.g., diabetes, hypertension, COPD) have more than one concurrent condition and are also at higher risk for developing comorbidities in mental health, including anxiety and depression. There is an urgent need for more relevant and accurate data on digital inter…

BACKGROUND: HIV is increasingly considered a chronic illness. More individuals are living longer and aging with the health-related consequences associated with HIV and multi-morbidity. Exercise is a self-management approach that can promote health for people aging with HIV. We examined the safety and effectiveness of p…

OBJECTIVE: several clinical trials have been published in recent years to investigate the potential benefits of physical exercise for women with breast cancer. This meta-epidemiological study aimed to map and critically assess the methodological quality of systematic reviews on physical activity for breast cancer patie…

OBJECTIVES: To evaluate the design, conduct, and analysis of systematic reviews on the diagnostic accuracy of rapid antigen tests for SARS-CoV-2 during the COVID-19 pandemic. STUDY DESIGN AND SETTING: We did a methodological overview of systematic reviews on diagnostic test accuracy, exploring methodological rigor, ri…

Recently, ultra-processed foods received a lot of attention, but also criticism. Our aim was to provide an overview of the existing evidence of ultra-processed food consumption on human health. We conducted a systematic search in four databases until January 5th, 2024. Systematic reviews with meta-analyses on ultra-pro…

BACKGROUND: Recently, several systematic reviews (SRs) and meta-analyses (MAs) of Tripterygium wilfordii polyglycoside (TWP) have reported significant benefits on diabetic kidney disease (DKD). However, the adoption of TWP for DKD remains uncommon. This study aimed to evaluate and summarize the current evidence on TWP…

BACKGROUND: Preconception exposures have been associated with adverse pregnancy, birth and postpartum outcomes. However, the reports, statements and guidelines of national and international health organisations vary in what they recommend individuals should monitor, avoid, reduce or practise in the preconception period…

AIM: Evidence of comparative effectiveness of different treatment approaches is important for clinical decision-making, yet absent for most recommended treatments of knee osteoarthritis pain. The objective of this study was to estimate the comparative effectiveness of exercise versus orally administered analgesics for…

BACKGROUND: Cerebral palsy is an umbrella term that encompasses disorders of movement and posture attributed to non-progressive disturbances occurring in the developing foetal or infant brain. As there are diverse risk factors and aetiologies, no one strategy will prevent cerebral palsy. Therefore, there is a need to s…

The nocebo effect has a significant impact on clinical trials and patient care. It leads to more frequent reports of adverse events, higher drop-out rates, and biased judgements of treatment efficacy. This review summarizes the findings from different disease areas and highlights the importance of psychological factors…

Consensus meetings and the resulting recommendations shape treatment choices in rare diseases such as hereditary angioedema (HAE) because they combine the experience of prescribing physicians and the patients who are receiving therapy. Self-administration of HAE therapy was recognised as a potential treatment option in…

Monitoring plasma levels of antiepileptic drugs for the treatment and prophylaxis of epilepsy is one of the strategies enabling clinical results to improve by reducing adverse affects and increasing effectiveness. The objective of this article is to review the basic aspects in the monitoring of antiepileptic drugs usin…

In France, critical reading of articles, a major challenge in the training of future physicians, was integrated into the program of the next national qualifying examinations which, at the end of graduate medical studies, enable to rank medical students for the allocation of future post-graduate training posts. The crit…

The quantitative analysis of the various clinical researches is carried out by means of special statistical data manipulation. It allows to receive results which cannot be taken from separate researches. In the article methodological bases of the meta-analysis and an opportunity of its application and interpretation in…

Evidence-based nursing is central to nursing practice. Systematic reviews have played a key part in providing evidence for decision making in nursing. Traditionally, these have consisted of syntheses of randomised controlled trials. New approaches to combining research include the synthesis of qualitative research. Thi…

UNLABELLED: In a forensic setting, deaths due to seizures, either epileptic or other, present a well-known problem. Cause of death is rarely established on the basis of physical evidence, but on circumstantial evidence such as tongue biting or discharge of urine or faeces. Seizures have several different aetiologies, b…

A commonly stated reason for dissatisfaction among nurses is that their input regarding patient care and suggestions for improvement in the workplace environment are not solicited or recognized. Nurses can have an active voice in their practice by using the five steps for implementing EBP and being involved in the proc…

Evidence-based care has heralded an advancement for health with extensive rhetoric and incentives encouraging clinicians to become active participants in practice change. This paper explores two mechanisms-research utilization and systematic reviews--as processes to develop empowerment in clinicians, and develop an eth…