381,523 papers found

INTRODUCTION: The promise of faster, simpler restorations has driven the rise of bulk-fill composites, but do speed and simplicity come at the cost of longevity and marginal integrity? OBJECTIVE: To compare and rank the clinical performance of bulk-fill and conventional incremental layering restoration techniques in C…

A meta-analysis of 11 randomized trials published between 1960 and 1970 was performed to re-evaluate data on the efficacy of dipyridamole in the prevention and treatment of chronic angina pectoris. Three trials significantly favored drug vs placebo, four showed a trend towards drug vs placebo, two showed no difference…

INTRODUCTION: Managing postoperative pain in patients following bariatric surgery is challenging. Although transversus abdominis plane block (TAPB) and erector spinae plane block (ESPB) have proved effective for pain relief, the analgesic efficacy between them remains controversial. This network meta-analysis was condu…

Perinatal corticosteroids are like a double-edged sword. On the one hand, they reduce risk for major morbidity and even mortality; on the other hand, they modify growth and development of body systems, with short- and long-term consequences. The relationship between corticosteroids and neurodevelopmental outcome has be…

Many meta-analyses combine results from only a small number of studies, a situation in which the between-study variance is imprecisely estimated when standard methods are applied. Bayesian meta-analysis allows incorporation of external evidence on heterogeneity, providing the potential for more robust inference on the…

A series of 1153 fine-needle aspiration biopsies (FNAB) of breast masses obtained during the period 1985 to 1988 in one institution was examined. The following diagnostic accuracy values were found: sensitivity, 93.0%; specificity, 92.4%; predictive positive value, 93.7%; and efficiency, 92.8%. These results were compa…

The hypothesis that individual differences in performance scores increase with increasing adult age was reviewed. A meta-analysis of memory articles appearing in the Journal of Gerontology from 1985 to 1990 was conducted to examine potential age differences in within-group variabilities. There was no strong evidence in…

A meta-analysis was carried out on the studies of chemotherapy of non small cell bronchial cancer published over the last fifteen years and this has demonstrated that the initial extent of the tumour was a significant prognostic factor in the response to treatment. A total of 6,247 patients were eligible for analysis:…

A meta-analysis of the original papers on human immunodeficiency virus (HIV) published in Spain was performed to better know the characteristics of HIV infection in Spain. Between 1985 and 1989, 67 investigations fulfilled the inclusion criteria. They were evaluated by means of a quantified questionnaire. The mean qual…

OBJECTIVES: To evaluate changes over time in summary estimates from meta-analyses of diagnostic accuracy studies. STUDY DESIGN AND SETTING: We included 48 meta-analyses from 35 MEDLINE-indexed systematic reviews published between September 2011 and January 2012 (743 diagnostic accuracy studies; 344,015 participants).…

We reviewed randomised clinical trials evaluating the effect of lymphoblastoid or recombinant alpha-interferon in non-A, non-B chronic hepatitis. The outcomes assessed were the rates of serum alanine aminotransferase normalization and relapse during and after stopping interferon. Data were pooled by meta-analysis and a…

The present paper focuses on drug-evaluation research, and describes a method of meta-analysis for evaluating the methodological quality of a body of research focusing on the study of an acute treatment medication. An illustrative application of this procedure to research evaluating lithium treatment for acute mania re…

The ability of prostaglandin E2 to prepare the unripe cervix before an indicated labor induction is controversial. We therefore tested 100 pregnant women in a randomized, double-blind trial with intracervical prostaglandin E2 gel, 0.5 mg. The 53 women who received the placebo gel had an outcome similar to that of the 4…