42,360 papers found

BACKGROUND: Obesity is a growing chronic health problem worldwide. Studies about acupuncture for obesity treatment are many. But there are some doubts about the effectiveness of acupuncture vs sham acupuncture in treating obesity due to its lack of an evidence-based medical proof. Therefore, the aim of this study is to…

PURPOSE: Metadherin (MTDH) is frequently overexpressed across human malignancies, yet its roles in head and neck cancer (HNC) remain incompletely characterized. This systematic review evaluates the biological functions, molecular mechanisms, and clinical relevance of MTDH in HNC. METHODS: A systematic literature searc…

Preoperative anxiety is common and has clinical consequences. Pharmacologic premedication remains widely used; however, its effectiveness varies, in part due to misalignment between drug timing and peak anxiety, as well as differences in patient risk profiles. This review aimed to synthesize the pharmacology, efficacy,…

BACKGROUND: Most antibiotic prescriptions occur in ambulatory care, making it a key setting for evaluating treatment outcomes. However, there is no consensus on how antibiotic treatment failure (ATF) is defined. OBJECTIVES: To systematically map definitions and criteria used to define ATF among patients with common ba…

PURPOSE: Dendrobium ("Shihu") and other Orchidaceae plants have been investigated as adjunctive options for inflammatory dermatoses, wound repair, and topical skin care. However, clinically relevant evidence and safety information remain scattered across phytochemistry, experimental dermatology, biomaterials, and formu…

OBJECTIVE: To explore the influence of choline and its derivatives (betaine, phospholipids) on the occurrence and development of neural tube defects. METHODS: A narrative review of the available research evidence (including both animal and human studies), based on literature identified through structured searches of d…

BACKGROUND: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged as a promising treatment for heart failure and cardiomyopathy. Furthermore, recent research has explored the use of SGLT2i in patients with dilated cardiomyopathy (DCM). However, the evidence that SGLT2i can improve left ventricular function a…

Quality of nursing care (QNC) is a central concept in healthcare systems worldwide, with growing emphasis on developing reliable and contextually appropriate instruments for its assessment. Over recent decades, there has been a shift from outcome-based evaluation toward more holistic, patient-centered frameworks that c…

PURPOSE: The purpose of this review is to discuss the role of fat-soluble vitamins in bone metabolism and explore whether there is a relationship between each fat-soluble vitamins in the occurrence and development of osteoporosis. METHODS: We selected several databases, including PubMed, PubMed Central (PMC), Embase,…

BACKGROUND: Sleep patterns significantly influence health and wellbeing, with disturbances to sleep quality and duration, and increased sleep disorders commonly affecting autistic people. The COVID-19 pandemic lockdown altered daily routines for almost all people, impacting their sleep patterns. AIM: This study aimed…

Self-report measures have been used as a tool to evaluate mania and depressive symptoms and aid in diagnosing bipolar disorder. The American Medical Association recommends that the evaluation reading be at a fifth- to sixth-grade level. The research literature has previously established that questionnaires regarding ot…

The prevalence of recidivism among individuals with a history of substance use and incarceration remains a significant concern for criminal justice systems worldwide. With significant social and economic ramifications, preventing people with a history of substance use from reoffending is a substantial issue. It is impe…

OBJECTIVE: To collect all studies on acute kidney injury of glomerular origin, published from Asia, even with their limitations, and look for causes and outcome in this particular population. METHOD: As of June 2024, a comprehensive literature search was conducted in the databases of PubMed, Cochrane Library, Web of S…

22q11.2 deletion syndrome (22q11.2DS) is one of the most common congenital malformation syndromes resulting from disrupted embryonic development of pharyngeal pouches. The classical triad of symptoms described by Angelo DiGeorge is frequently accompanied by hematological and immune disorders. While it is well-establish…

BACKGROUND: Misinformation represents a serious and growing concern for public health and healthcare health; and has attracted much interest from researchers, media, and the public over recent years. Despite increased concern about the impacts of misinformation on health and wellbeing, however, the concept of health mi…

BACKGROUND: The choroid, a highly vascular structure within the eye, is significantly influenced by various systemic conditions. The advent of enhanced depth optical coherence tomography has improved our ability to evaluate choroidal pathophysiology. The choroidal vascularity index (CVI), a noninvasive and reliable too…

BACKGROUND: Psychosocial work factors significantly influence both organisational and worker health. Poor management of these factors can create precarious working conditions, risking drivers' health. This review maps evidence on the health impact of these factors and health interventions targeting the working conditio…

BACKGROUND: Diarrhea is a prevalent condition affecting millions worldwide. However, current standard diagnostic methods have many drawbacks. This review examines various non-invasive point-of-care (POC) tests and biomarkers aiding rapid diagnosis of diarrhea from different causes. METHODS: PubMed, PubMed Central, Sci…

BACKGROUND: Hypertension is a leading cause of cardiovascular disease. This review examines the literature on hypertension control in the Czech Republic from 1972 to 2022 addressing limited data on its effectiveness. METHODS: A literature review was conducted covering the period from 1972 to 2022, utilizing…

BACKGROUND AND OBJECTIVE: The issue of racial and ethnic disparities in healthcare has been a significant concern for many years. It encompasses various aspects, including disease prevention, diagnosis, management, and end-of-life (EOL) care. Research has found that timely intervention with palliative care can result i…