5,004,941 papers found

In 2010, an international consensus conference was held to review current evidence regarding the pathology, prevention, and management of incontinence-associated dermatitis (IAD). The results of this literature review were published in a previous issue of this Journal. This article summarizes key consensus statements a…

Red meat and processed meat intake is associated with a risk of colorectal cancer, a major cause of death in affluent countries. Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer. This meta-analysis of prospective cohort studies of colon cancer r…

INTRODUCTION: This study was conducted to provide Intensive Care Units and Emergency Departments with a set of practical procedures (check-lists) for managing critically-ill adult patients in order to avoid complications during intra-hospital transport (IHT). METHODS: Digital research was carried out via the MEDLINE,…

INTRODUCTION: Meta-analyses have been suggested to be the highest form of evidence available to clinicians to guide clinical practice in dental care. High methodologic quality is a prerequisite for valid interpretation and application of review findings. However, meta-analyses are complex exercises, and assessing quali…

AIM: The aim of this paper is to present an update of the Back School concept including recent randomised controlled studies, systematic reviews and guidelines. METHOD: After definition and classification of the origins of the Back School concept, results of randomised controlled studies and systematic reviews within…

The survival of patients who present to the emergency department with severe injury or illness is dismal. Resuscitation researchers are interested in advancing the science of resuscitation, and clinical studies must be conducted to determine the best treatment protocols. These studies must reflect good science and must…

INTRODUCTION: Cancer is a major global health concern, and immune checkpoint inhibitors (ICIs) offer a promising treatment option for cancer patients. However, the efficacy of ICIs can be influenced by various factors, including the use of concomitant medications. METHODS: We searched databases (PubMed, Embase, Cochra…

BACKGROUND: The majority of people with a chronic disease (e.g., diabetes, hypertension, COPD) have more than one concurrent condition and are also at higher risk for developing comorbidities in mental health, including anxiety and depression. There is an urgent need for more relevant and accurate data on digital inter…

BACKGROUND: HIV is increasingly considered a chronic illness. More individuals are living longer and aging with the health-related consequences associated with HIV and multi-morbidity. Exercise is a self-management approach that can promote health for people aging with HIV. We examined the safety and effectiveness of p…

BACKGROUND: Epilepsy is a neurological disorder affecting both children and adults. Epileptic seizures are the result of excessive and abnormal cortical cell electrical activity in the brain. In response to criticism that epilepsy care for children has little impact on long-term outcomes, healthcare professionals and a…

PURPOSE: The importance of meniscus integrity in the prevention of early osteoarthritis is well known, and preservation is accepted as the primary goal. The purpose of the ESSKA (European Society for Sports Traumatology, Knee Surgery and Arthroscopy) European consensus on traumatic meniscus tears was to provide recomme…

The nocebo effect has a significant impact on clinical trials and patient care. It leads to more frequent reports of adverse events, higher drop-out rates, and biased judgements of treatment efficacy. This review summarizes the findings from different disease areas and highlights the importance of psychological factors…

Consensus meetings and the resulting recommendations shape treatment choices in rare diseases such as hereditary angioedema (HAE) because they combine the experience of prescribing physicians and the patients who are receiving therapy. Self-administration of HAE therapy was recognised as a potential treatment option in…

Monitoring plasma levels of antiepileptic drugs for the treatment and prophylaxis of epilepsy is one of the strategies enabling clinical results to improve by reducing adverse affects and increasing effectiveness. The objective of this article is to review the basic aspects in the monitoring of antiepileptic drugs usin…

In France, critical reading of articles, a major challenge in the training of future physicians, was integrated into the program of the next national qualifying examinations which, at the end of graduate medical studies, enable to rank medical students for the allocation of future post-graduate training posts. The crit…

The quantitative analysis of the various clinical researches is carried out by means of special statistical data manipulation. It allows to receive results which cannot be taken from separate researches. In the article methodological bases of the meta-analysis and an opportunity of its application and interpretation in…

Evidence-based nursing is central to nursing practice. Systematic reviews have played a key part in providing evidence for decision making in nursing. Traditionally, these have consisted of syntheses of randomised controlled trials. New approaches to combining research include the synthesis of qualitative research. Thi…

UNLABELLED: In a forensic setting, deaths due to seizures, either epileptic or other, present a well-known problem. Cause of death is rarely established on the basis of physical evidence, but on circumstantial evidence such as tongue biting or discharge of urine or faeces. Seizures have several different aetiologies, b…

A commonly stated reason for dissatisfaction among nurses is that their input regarding patient care and suggestions for improvement in the workplace environment are not solicited or recognized. Nurses can have an active voice in their practice by using the five steps for implementing EBP and being involved in the proc…

Evidence-based care has heralded an advancement for health with extensive rhetoric and incentives encouraging clinicians to become active participants in practice change. This paper explores two mechanisms-research utilization and systematic reviews--as processes to develop empowerment in clinicians, and develop an eth…