98,318 papers found

OBJECTIVE: Muscle involvement is a frequent histopathologic feature of sarcoidosis, but its clinical presentation has been rarely reported and its longterm outcome is unclear. We describe the features and outcome of 5 patients with muscle sarcoidosis. METHODS: A retrospective study from hospital charts over the period…

A variant of the only island flap urethroplasty in severe hypospadias repair is described. The principles of technique are: mobilizing of urethral plate, without dividing it, in order to release chordee; creation of pedicle island flap on the dorsal penile skin, with redundant vascularized tissue, which is transposed t…

BACKGROUND: Chemotherapy at the end of life is a complex and challenging problem in medical oncology. Patients affected by ovarian cancer (OC) often experience a chronicization and slow progression of their disease, and chemotherapy is proposed until the end of life. METHODS: We retrospectively analyzed data from pati…

Uveitis is an inflammation of the anatomical layer, which consists of the iris, ciliary body and choroid. Pediatric uveitis is rare, but tends to be more severe and chronic than in adults. This study aims to evaluate the etiology, clinical features, treatment and complications in pediatric uveitis. In this study, the f…

INTRODUCTION: The effectiveness of the hepatitis C virus (HCV) treatment seems to be lower in people who inject drugs (PWID). We analyze the influence of various factors as psychiatric disorders and opioid substitution therapy (OST) on the treatment with direct-acting antivirals (DAA) in this collective. PATIENTS AND…

OBJECTIVE: To explore the safety and effectiveness of graded infusion of bone cement in the unipedicular percutaneous vertebroplasty (PVP) for Kummell's disease. METHODS: Eighteen patients with Kummell's disease were treated by unipedicular PVP with graded infusion of bone cement between January 2012 and January 2014.…

Multiple sclerosis (MS) is a neurodegenerative disease with a complex autoimmune component, and it has a high prevalence among middle-aged females. The manifestations of the disease range from episodic somatosensory dysfunction to progressive and permanent central nervous system (CNS) damage. Due to a high prevale…

Over a period of 8 years, 5,216 percutaneous transluminal angioplasties (PTA) and local thrombolysis were performed in the Department of Radiology of the University of Freiburg and the Hochrheinklinik of Bad Säckingen. From 1984 to 1989, 5,216 patients were reviewed clinically, and, in 360 cases, angiographically.…

The aim of the study was to review the distribution, current trends, and microbiological characteristics of bacterial pathogens isolated from dacryocystitis patients in China during the last 15 years.This is a retrospective multiple-center noncomparative case series. The medical records of 15,452 consecutive patients f…

Pamidronate treatment has been shown to improve outcome in osteogenesis imperfecta (OI); however, factors influencing outcome are unclear. The present study was conducted to evaluate the response to pamidronate therapy with special emphasis on factors influencing outcome. Twenty children with OI treated with pamidronat…

PURPOSE: To compare the long-term outcomes of living-related conjunctival limbal allograft (lr-CLAL) with keratolimbal allograft (KLAL) in patients with limbal stem cell deficiency. METHODS: A retrospective, comparative, interventional cohort of patients with bilateral total limbal stem cell deficiency who underwent s…

OBJECTIVES: To evaluate the time course of "taking to bed" at the end of life and determine whether it differs according to age, sex, and condition leading to death. DESIGN: Prospective longitudinal study. SETTING: Greater New Haven, Connecticut. PARTICIPANTS: A total of 651 decedents from a cohort of 754 community-…

Bridged oligophenylenes are very important organic semiconductors (OSCs) in organic electronics (OE). The fluorene unit, which is a bridged biphenyl, is the spearhead of this class of materials and has, over the last 20 years, led to fantastic breakthroughs in organic light-emitting diodes. Dihydroindenofluorenes belon…

OBJECTIVES: We investigated the incidence rate and type of cancer, and furthermore, estimated the standardised incidence ratios (SIRs) of cancer in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Korea. METHODS: We retrospectively included 150 patients with AAV [81 patients with…

OBJECTIVE: To analyze trends in incidence and treatment of thermal injuries over the last two decades. METHODS: We retrospectively reviewed our local single center database of patients with thermal injuries admitted to the burn intensive care unit (BICU) of the Cologne-Merheim Medical Center (University Hospital of Wi…

OBJECTIVE: To investigate the symptoms, factors relating to recurrences, the styles of the rescue operation and the reconstructive methods of the surgical defects in patients with recurrent nasal and paranasal sinus neoplasms. METHODS: Excluding the primary neoplasm, only patients with recurrent tumors and suitable fo…

Simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, has been administered to approximately 2,400 patients with primary hypercholesterolemia with a mean follow-up of 1 year in controlled clinical studies and their open extensions. Approximately 10% of this population received simvastatin for a peri…

Beyond the legal and regulatory limitations associated with biosimilar availability in the United States, the adoption of biosimilars is contingent on the willingness of health care providers (HCPs) to prescribe them and of patients to accept them. In this dynamic market, it is of paramount importance to understand the…

BACKGROUND: Cardiac involvement is common in amyloidosis, and the vast majority of cases of amyloid cardiomyopathy are attributed to primary amyloidosis or transthyretin amyloidosis (ATTR). Although the coexistence of scintigraphy suggestive of ATTR with monoclonal gammopathy of undetermined significance is well docume…

There is no better treatment method for the cholecystolithiasis accompanied by symptoms than the cholecystectomy. In the so-called mute gall an expecting attitude is justified. During the last years for selected patients with gallstones and calculi in the common bile duct, respectively, non-surgical therapeutic methods…