A comparison of statistical methods for combining relative bioactivities from parallel line bioassays.
Mzolo Thembile, Hendriks Marga, van den Heuvel Edwin·Pharmaceutical statistics
This paper compares the ordinary unweighted average, weighted average, and maximum likelihood methods for estimating a common bioactivity from multiple parallel line bioassays. Some of these or similar methods are also used in meta-analysis. Based on a simulation study, these methods are assessed by comparing coverage…