375,956 papers found

Depression, a condition severely endangering individual health and societal progress, is projected by the WHO to become the leading global disease burden by 2030. Currently, three categories of therapies are employed in clinical practice: psychotherapy, pharmacotherapy, and physical therapy. The treatment strategies ut…

BACKGROUND: Bronchopulmonary dysplasia (BPD) is a prevalent and severe chronic respiratory condition in preterm infants, with vitamin deficiency recognized as a contributing factor. Although vitamins A and D are known to play protective roles in lung development, the optimal supplementation doses for BPD prevention rem…

A meta-analysis of 11 randomized trials published between 1960 and 1970 was performed to re-evaluate data on the efficacy of dipyridamole in the prevention and treatment of chronic angina pectoris. Three trials significantly favored drug vs placebo, four showed a trend towards drug vs placebo, two showed no difference…

The authors describe some situations where meta-analyses would have been of great benefit if they have been done or sufficiently published. They emphasize several problems ensued by this new method: if possible, meta-analyses have to be done each time a new trial is analysed, according to a precise method. Cumulative m…

OBJECTIVE: To compare the effects of different exercise modalities on depressive and anxiety symptoms in patients with cancer and to explore the exercise dose-response relationship to identify the optimal dose. METHODS: Randomized controlled trials published from database inception to January 2026 were searched in Pub…

BACKGROUND: Few studies have compared the effects of different types of exercise on the management of patients with fibromyalgia. Therefore, we conducted this systematic review with meta-analysis to evaluate the effects of three types of exercise on the treatment of fibromyalgia. METHODS: Search databases including Pu…

This paper is a response to the paper "Breast Implant Illness, Outcomes with Explantation, and Potential Etiologies, a Systematic Review and Meta-Analysis". There are scientific inconsistencies and misleading statements in this paper that we felt needed to be addressed.Level of Evidence IV This journal requires th…

Many meta-analyses combine results from only a small number of studies, a situation in which the between-study variance is imprecisely estimated when standard methods are applied. Bayesian meta-analysis allows incorporation of external evidence on heterogeneity, providing the potential for more robust inference on the…

OBJECTIVES: To evaluate changes over time in summary estimates from meta-analyses of diagnostic accuracy studies. STUDY DESIGN AND SETTING: We included 48 meta-analyses from 35 MEDLINE-indexed systematic reviews published between September 2011 and January 2012 (743 diagnostic accuracy studies; 344,015 participants).…

A meta-analysis was carried out on the studies of chemotherapy of non small cell bronchial cancer published over the last fifteen years and this has demonstrated that the initial extent of the tumour was a significant prognostic factor in the response to treatment. A total of 6,247 patients were eligible for analysis:…

This study investigated the dose-response relationships between different exercise modalities and blood pressure in individuals with metabolic syndrome. The review was conducted in accordance with PRISMA-NMA guidelines. Electronic databases, including PubMed, Web of Science, Embase, and the Cochrane Central Register of…

BACKGROUND: The optimal non-pharmacological intervention for improving social participation after stroke remains unclear. This network meta-analysis (NMA) aimed to compare the effectiveness of different interventions and identify the best approach. METHODS: Cochrane Library, Web of Science, PubMed, Embase, CINAHL plus…

The hypothesis that individual differences in performance scores increase with increasing adult age was reviewed. A meta-analysis of memory articles appearing in the Journal of Gerontology from 1985 to 1990 was conducted to examine potential age differences in within-group variabilities. There was no strong evidence in…

The present paper focuses on drug-evaluation research, and describes a method of meta-analysis for evaluating the methodological quality of a body of research focusing on the study of an acute treatment medication. An illustrative application of this procedure to research evaluating lithium treatment for acute mania re…

The ability of prostaglandin E2 to prepare the unripe cervix before an indicated labor induction is controversial. We therefore tested 100 pregnant women in a randomized, double-blind trial with intracervical prostaglandin E2 gel, 0.5 mg. The 53 women who received the placebo gel had an outcome similar to that of the 4…

A meta-analysis of the original papers on human immunodeficiency virus (HIV) published in Spain was performed to better know the characteristics of HIV infection in Spain. Between 1985 and 1989, 67 investigations fulfilled the inclusion criteria. They were evaluated by means of a quantified questionnaire. The mean qual…