5,006,524 papers found

BACKGROUND: Resource-poor individuals, such as those with a low income, are disproportionately affected by diabetes and unhealthy eating patterns that contribute to poor disease self-management and prognosis. Digitally delivered interventions have the potential to address some of the barriers to healthy eating experien…

IMPORTANCE: Systematic reviews and meta-analyses are considered the best evidence for clinical decision making. Many reviews of intraoperative neuromonitoring (IONM) in thyroidectomy have conflicting results, owing in large part to methodological quality. OBJECTIVE: To assess the methodological quality and the causes…

BACKGROUND: Since the authorization of glitazones as oral antidiabetics, there has been a controversial debate as to whether they increase the risk of bladder cancer or accelerate its progression. Recent data have shown that glitazones can upregulate the expression of Nectin4. OBJECTIVES: These results make a&#xa…

The effectiveness of international border control measures during the COVID-19 pandemic is not well understood. Using a narrative synthesis approach to published systematic reviews, we synthesized the evidence from both modelling and observational studies on the effects of border control measures on domestic transmissi…

OBJECTIVES: We systematically evaluated causal language use in systematic reviews of observational studies and explored the relation between language use and the intent of the investigation. STUDY DESIGN AND SETTING: We searched EMBASE, MEDLINE, and Epistemonikos. We randomly selected 199 reviews published in 2019, st…

To summarize the microbiome's role in metabolic disorders (insulin resistance, hyperglycemia, type 2 diabetes, obesity, hyperlipidemia, hypertension, nonalcoholic fatty liver disease [NAFLD], and metabolic syndrome), systematic reviews on observational or interventional studies (prebiotics/probiotics/synbiotics/transpl…

BACKGROUNDS: Primary prevention of suicidal behaviors in the general population is required to interrupt the trend of self-inflicted deaths worldwide. We reviewed the evidence of the efficacy of primary prevention of suicide among the adult population. METHODS: This is an overview of systematic reviews. We searched Pu…

BACKGROUND: Prehabilitation before knee joint replacement surgery is gaining increasing importance due to the rising prevalence of knee osteoarthritis. The aim is to optimize the preoperative condition to improve postoperative recovery and reduce complications. MATERIALS AND METHODS: This review is based on a sys…

PURPOSE OF REVIEW: There is an ongoing explosion in the amount and quality, of research in the field of Endourology. From a solid basis of systematic reviews and small, single centre trials it has been possible to design large randomised controlled trials in the UK and in the USA. This review will describe some of the…

Objectives To identify the agriculture, food, and nutrition security interventions that facilitate sustainable food production and have a positive impact on health. Methods Systematic review methods were used to synthesize evidence from multiple systematic reviews and economic evaluations through a comprehensive search…

Multiple randomized controlled trials on in-home end-of-life (EOL) programs, often with multifaceted and varying components, have shown benefits and reduced costs. The objective of this review was to determine which components of these programs are most commonly associated with better outcomes than usual care. MEDLINE,…

BACKGROUND: Although conventional adenocarcinoma accounts for the majority of prostatic carcinomas, it is important to recognize rare variants, like basal cell carcinoma (BCC), which has distinctive histopathological and biological features. CASE REPORT: We analyzed three cases of prostatic BCC and all of them complai…

OBJECTIVES: The objective of this study was to examine the methods used in systematic reviews of safety across a range of complementary therapies to assess the variation in approach and the potential for developing guidance on conduct and reporting. DESIGN: Systematic reviews focusing on safety were retrieved from NHS…

The application of neuro-modulation techniques in general is currently gaining acceptance in various aspects of medicine. Neuro-modulation is defined as: "Therapeutical interventions using implantable devices to modify the functioning of central, peripheral and autonomic nervous systems". Following lumbar disc surgery,…

Abnormal uterine bleeding in terms of menstrual disorders and postmenopausal bleeding are common clinical problems in both primary and secondary care. Advances in diagnostic and therapeutic technologies have offered opportunities to improve the outcomes of women suffering with these complaints. Future research should c…

INTRODUCTION: Chronic progressive external ophthalmoplegia is a common mitochondrial disease that shares clinical, enzymatic, and genetic features with other mitochondrial disorders. Effective treatment does not exist, and corrective surgery of the ptosis as a palliative measure is a treatment option. PATIENTS AND MET…

OBJECTIVE: To explore development of possible approaches leading to a sensitive and precise Medline search to identify observational studies of the association between oral contraceptives and breast cancer, an adverse event. STUDY DESIGN AND SETTING: We compared the results of a series of Medline searches to a gold st…