5,006,524 papers found

OBJECTIVE: In 2003, critical care and infectious disease experts representing 11 international organizations developed management guidelines for early goal-directed therapy that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, an international effort to increase…

In this article we review the evidence supporting the need to achieve a target blood pressure (BP) under 130-80 mm Hg in diabetic patients, as recent international guidelines recommend (JNC VII, ESH-ESC and ADA). We have analyzed the explicit arguments used in these guidelines, 3 clinical trials designed to determine w…

PURPOSE: Despite extensive research on gastric cancer (GC), efforts to consolidate the numerous associations between possible factors and GC risk remain lacking. This systematic review aimed to provide an overview of potential GC-associated pairs. MATERIALS AND METHODS: We systematically searched PubMed, Embase, and C…

BACKGROUND: The interaction between heredity and different environmental factors in the modification of apical periodontitis (AP) susceptibility and prediction of its progression remain poorly elucidated. OBJECTIVES: This umbrella review aimed to (i) analyse the available relevant systematic reviews in an attempt to d…

PURPOSE OF REVIEW: The aim of this study was to summarize the literature on the impact of COVID-19 on older adults with cancer, including both the impacts of COVID-19 diagnosis on older adults with cancer and the implications of the pandemic on cancer care via a synthesis of reviews, guidelines and other relevant liter…

OBJECTIVE: Percutaneous cholecystostomy (PC) is used for the treatment of acute cholecystitis in patients with high surgical risk due to the severity of cholecystitis and/or the underlying acute or chronic medical comorbidities. The evidence for this strategy is unclear. MATERIALS AND METHODS: We searched PubMed and t…

Overview of reviews, compiling evidence from multiple Cochrane reviews into one accessible and usable document, is a new methodology being developed by the Cochrane methods group and mastered by the Child Health Network. Overviews of reviews are rapidly gaining in popularity as a 'friendly front end' to the Cochrane Li…

BACKGROUND: Most systematic reviewers aim to perform an intention-to-treat meta-analysis, including all randomized participants from each trial. This is not straightforward in practice: reviewers must decide how to handle missing outcome data in the contributing trials. OBJECTIVE: To investigate methods of allowing fo…

The goals of the Baveno workshops were to develop consensus definitions of key events related to portal hypertension and variceal bleeding, and to produce guidelines to facilitate the conduct and reporting of clinical trials. The consensus definitions concern the diagnosis of active bleeding, failure to control bleedin…

OBJECTIVE: To assess the quality, biases, and validity of evidence on maternal paracetamol (acetaminophen) use during pregnancy and the risk of autism spectrum disorder (referred to as autism) and attention deficit/hyperactivity disorder (ADHD) in offspring. DESIGN: Umbrella review of systematic reviews. DATA SOURCES…

OBJECTIVES: In 2006, Academic Emergency Medicine (AEM) published a special issue summarizing the proceedings of the AEM consensus conference on the "Science of Surge." One major goal of the conference was to establish research priorities in the field of "disasters" surge. For this review, we wished to determine the pro…

OBJECTIVE: to analyze the attributes, antecedents and consequents of the family conference concept. METHOD: Walker and Avante's method for concept analysis and the stages of the integrative review process, with a selection of publications in the PubMed, Cinahl and Lilacs databases focusing on the family conference the…

The objective of this study was to overview high-qualitative systematic reviews to synthesize the evidence for associations between sedentary behavior and health outcomes in adults. There is evidence for a cross-sectional association between accelerometer measured sedentary time and poorer insulin sensitivity, and an a…

Although multiple innovative treatments of inflammatory bowel disease have become available, research continues to refine the value of existing drug therapies for Crohn's disease and ulcerative colitis. What can Cochrane reviews tell us about evolving applications for traditional agents in inflammatory bowel disease? A…

Systematic reviews (SRs) of the literature are clinical research studies carried out according to rigorous methodological criteria. They are aimed at searching, critically appraising and summarizing all studies with similar characteristics that address the same research question. The Cochrane Collaboration is the main…

The present chapter describes the most important available experimental and clinical evidence on the role of electrical stimulation of the cerebellum or the thalamus in the control of epilepsy. Cerebellum serves as an integrator of sensory information and regulator of motor coordinating and training. The sole output of…

For over a century, various neuroanatomical measures have been employed as assays of cognitive ability in comparative studies. Nevertheless, it is still unclear whether these measures actually correspond to cognitive ability. A recent meta-analysis of cognitive performance of a broad set of primate species has made it…

Blood gas management during hypothermic cardiopulmonary bypass may be corrected by pH stat or alpha stat strategy. The pH stat philosophy is to maintain the blood pH constant at any temperature. Carbon dioxide must be introduced to the oxygenator in order to maintain the pH and pCO2 during hypothermic cardiopulmonary b…

Despite major advances in inotropic medications and our understanding of their proper use, surgical management of heart failure is the fastest-growing aspect of cardiovascular surgery. In addition to causing 750,000 deaths annually, myocardial infarctions leave an estimated 60,000 more patients in severe congestive hea…