44,715 papers found

Hereditary transthyretin amyloidosis (ATTRv) is a rare, autosomal dominant, inherited disease caused by variants in the gene encoding the transthyretin (TTR) protein. These variants lead to TTR tetramer destabilization, resulting in the formation and progressive deposition of insoluble amyloid fibrils in various tissue…

Horner's syndrome is a rare complication of thyroid surgery and is most commonly reported as a complication associated with lateral neck dissection. We present the case of a 46-year-old woman who developed a partial Horner's syndrome following hemithyroidectomy and central neck dissection, without lateral neck dissecti…

Intergenerational programmes can provide numerous benefits including fostering meaningful relationships and improving understanding of other age groups. Despite a recent increase in popularity, intergenerational dance programmes remain under-researched and under-synthesised. The aim of this review was to synthesise the…

Neural tube defects (NTDs) are a major public health concern that greatly raises newborn mortality and morbidity rates. The aim of this systematic review and meta-analysis was to determine the overall prevalence of NTDs across various regions of India. A random-effects model was used to analyze 33 observational studies…

Many microsurgeons recommend that their patients avoid all compounds containing caffeine after free tissue transfer, however, there is little in the literature to implicate caffeine as a contributor to flap loss. While caffeine has historically been viewed as a vasoconstrictor that could theoretically impair flap perfu…

UNLABELLED: In recent years, there has been a notable surge in interest in gender medicine, with a growing focus on exploring gender and sex differences in skin diseases.Although it is noticeable in clinical practice that more women than men present with chronic spontaneous urticaria (CSU) in the outpatient setting, th…

BACKGROUND: There is a significant gap in understanding which strategies effectively enhance vaccination rates for recommended adult vaccines in primary care settings. This review aimed to identify interventions in outpatient clinics that increase vaccination rates for commonly recommended adult vaccines and describe t…

The aim of the systematic review is to analyze the type and the prevalence of dental side effects among cancer survivors treated with alkylating agents (AAs) during pediatric age. Moreover, the study aimed to investigate the association between the development of dental anomalies and the drug used or the tumor type. Fo…

UNLABELLED: Tumor tissue samples are necessary for histological diagnosis. Biopsy is associated with certain difficulties, especially in neuro-oncology. An alternative approach (liquid biopsy) is currently being developed. The last one is based on analysis of biological fluids regarding DNA of tumors and other biomarke…

BACKGROUND: Dyspnea is an important non-motor symptom in Parkinson's disease (PD) that impacts quality of life. The mechanisms underlying dyspnea have been difficult to determine due to challenges separating central respiratory control abnormalities from peripheral respiratory muscle dysfunction and chest wall rigidity…

BACKGROUND: Metal sensitivity is a possible cause for revision in elective lower-limb arthroplasty. This scoping review aims to identify and evaluate all existing and novel assessment methods for metal sensitivity in elective lower-limb arthroplasty. METHODS: The Cochrane Central Register of Controlled Trials (CENTRAL…

INTRODUCTION/OBJECTIVE: Multiple sclerosis (MS), is characterized by autoimmune-driven neuroinflammation, axonal degeneration, and demyelination. This study aimed to explore the therapeutic potential of targeting Notch signaling within the central nervous system (CNS) in the context of MS. Understanding the intricate r…

Interest in naturally occurring phytochemicals has been on the increase, they are believed to reduce the risk of brain disorders. Hispidulin (HN) is a phenolic flavonoid compound with various pharmacological and biological effects on the central nervous system. It belongs to the flavone class of flavonoids. It can be f…

BACKGROUND: Shoulder pain is one of the most common symptoms after laparoscopic surgery, which seriously affects people's health and quality of life. Many clinical studies have shown that noninvasive physiotherapy is the most beneficial treatment for patients, but the best approach for various noninvasive physiotherapy…

OBJECTIVE: To estimate pooled prevalence of depression, anxiety, and sleep disturbances in neuromyelitis optica spectrum disorders (NMOSD) cases. METHODS: Electronic database of PubMed (MEDLINE), the Cochrane Central Register of Controlled Trials (CENTRAL), Embase and Web of Science ware systematically searched to ide…

BACKGROUND: The aim of this scoping review was to identify factors that would enable or hinder the opportunity for laypersons to undertake resuscitation education. METHODS: We searched PubMed, Ovid EMBASE, CINAHL, and the Cochrane Central Register of Controlled Trials (CENTRAL) to identify studies published from Janua…

The aim of this meta-analysis is to assess the efficacy of extracorporeal shockwave therapy (ESWT) in patients with peripheral arterial disease (PAD). This meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search was c…

Following the "call for action to research", various aspects of maternity care should be examined so that perinatal care can be improved based on evidence. Clinical midwifery is the most common way of attending births in high-income countries. Midwives are the experts for normal labor and birth and play a central role…

BACKGROUND: Pharmacologic and non-pharmacologic treatments for stroke are essential but can be costly or harmful, whereas probiotics are a promising alternative. This scoping review aimed to synthesize theandevidence of probiotics on stroke-related neurological, biochemical, and histochemical outcomes. METHODS: A syst…

Optical coherence tomography is a noninvasive imaging technology using the optical reflectivity of tissues that is capable of detecting quantitative and qualitative biomarkers of age-related macular degeneration (AMD) that cannot be similarly recognized in conventional imaging. We systematically searched PubMed and Emb…