42,377 papers found

BACKGROUND: Pathogenic variations in the gene encoding the skeletal muscle ryanodine receptor (RyR1) are associated with malignant hyperthermia (MH) susceptibility, a life-threatening hypermetabolic condition and RYR1-related myopathies (RYR1-RM), a spectrum of rare neuromuscular disorders. In RYR1-RM, intracellular ca…

The antidiabetic effect of empagliflozin in patients with type 2 diabetes mellitus has been explored in several trials. We performed this meta-analysis determining the effects of empagliflozin on blood pressure, uric acid, estimated glomerular filtration rate, blood lipids, blood glucose, and body weight in patients wi…

STUDY OBJECTIVES: Chronic pain and comorbid sleep difficulties impact many children and adolescents. This study aimed to evaluate the efficacy of psychological interventions on sleep in children and adolescents with chronic pain. METHODS: Five databases (PubMed, CINAHL, APA PsychInfo, Embase, CENTRAL) were searched fr…

BACKGROUND: Bladder EpiCheck (BE) is a novel methylation-based PCR urine test for the detection of non-muscle invasive bladder cancer (NMIBC) recurrences. OBJECTIVE: We present the results of a North American study evaluating BE and meta-analysis of literature. METHODS: A prospective, blinded, multicenter study was c…

OBJECTIVE: Nowadays, body mass index (BMI) is used to evaluate the risk stratification of obesity-related pregnancy complications in clinics. However, BMI cannot reflect fat distribution or the proportion of adipose to nonadipose tissue. The objective of this study is to evaluate the association of maternal first or se…

OBJECTIVE: The research regarding the central mechanism of acupuncture(arrival of) based on functional magnetic resonance imaging (fMRI) in recent 10 years was analyzed to summarize existing research achievements and experience. METHODS: The literature regarding fMRI-basedresearch published from January of 2007 throug…

INTRODUCTION: With the high incidence of central venous access device catheter-related thrombosis (CRT) in patients with cancer, its early onset, and the characteristics of clinically insignificant symptoms, risk assessment is essential for the targeted application of thromboprophylaxis. The aim of this paper was to re…

Studies showed that integrating coating or valve into Peripherally Inserted Central (PICC) can prevent related complications. However, data regarding efficiency were controversial. Therefore, a systematic review was needed to analyse the effect of PICC materials and designs on reduction of PICC-related complicatio…

BACKGROUND: Data and best practice recommendations for transcranial magnetic stimulation (TMS) use in adults are largely available. Although there are fewer data in pediatric populations and no published guidelines, its practice in children continues to grow. METHODS: We performed a literature search through PubM…

BACKGROUND AND OBJECTIVE: Despite Bacillus Calmette-Guerin (BCG) remaining the standard of care for high-risk non-muscle-invasive bladder cancer (HR-NMIBC), novel combination strategies are being actively investigated. Comparative evidence on the efficacy and tolerability of these regimens in BCG-naïve patients re…

OBJECTIVES: α-lipoic acid (ALA) is a natural antioxidant which acts as a cofactor of bioenergetic mitochondrial enzymes. Along with its mitochondrial action, ALA and its reduced form have many biological functions resulting in a wide variety of actions such as anti-inflammation and antioxidant protection, scaveng…

To report 2 cases of superficial siderosis of central nervous system (SS-CNS) and a review of the literature.We have analyzed the clinical data and relevant features of two patients with SS-CNS who were presented with ataxia and slurred speech. Both patients undertook blood tests, lumbar puncture, head CT (computer tom…

INTRODUCTION: Type 2 Diabetes Mellitus (T2DM) and Alzheimer's Disease (AD) share complex metabolic disturbances, with cholesterol dysregulation emerging as a central mechanistic link. Although brain cholesterol metabolism operates largely independently of peripheral lipid pools, it is highly susceptible to disruption,…

PURPOSE: Accurate hemodynamic monitoring is essential for personalized care in surgical and intensive care unit (ICU) settings, and radial artery catheters are the gold standard. Nevertheless, central-to-peripheral arterial blood pressure gradients (CPAPGs) have been reported in up to 77% of patients, potentially leadi…

BACKGROUND: Extended mesocolic lymph node dissection in colon cancer surgery seems to improve oncological outcome. A possible reason might be related to metastases in the central mesocolic lymph nodes. OBJECTIVE: The purpose of this study was to describe the pattern of mesocolic lymph node metastases, particularly in…

BACKGROUND: The risk factors for central venous access device-related thrombosis (CRT) in children are not fully understood. We used evidence-based medicine to find the risk factors for CRT by pooling current studies reporting risk factors of CRT, aiming to guide clinical diagnosis and treatment. METHODS: A systematic…

BACKGROUND/INTRODUCTION: In patients with acute vestibular syndrome (AVS), differentiating between stroke and nonstroke causes is challenging in the emergency department (ED). Correct diagnosis of vertigo etiology is essential for early optimum treatment and disposition. OBJECTIVES: The aim of this systematic review a…

Because the application of intracavitary electrocardiogram (IC-ECG)-guided peripherally inserted central catheter (PICC) in the treatment of neonates is controversial in terms of phlebitis reduction compared with traditional X-ray positioning technique, a systematical evaluation is needed on the impact of IC-ECG on thi…

Hereditary transthyretin amyloidosis (ATTRv) is a rare, autosomal dominant, inherited disease caused by variants in the gene encoding the transthyretin (TTR) protein. These variants lead to TTR tetramer destabilization, resulting in the formation and progressive deposition of insoluble amyloid fibrils in various tissue…

OBJECTIVE: This proposed scoping review aims to provide an overview of climate-related intervention studies that measure both climate action and psychological health as outcomes, regardless of whether the intervention primarily seeks to promote climate action, psychological health, or both. INTRODUCTION: The interplay…