44,726 papers found

PURPOSE: The surgical methods of degenerative lumbar spinal stenosis include spinal decompression with or without instrumented or non-instrumented spinal fusion. Previous meta-analysis and systematic reviews have reported the contrast between surgical management and nonsurgical management for degenerative lumbar spinal…

In this study, we evaluated if male circumcision was associated with lower HIV acquisition for HIV (-) males and HIV (-) females during normal sexual behavior. We performed a systematic literature search of PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) databases to identify studies that c…

Proposal of success criteria for strabismus surgery for patients with Graves' orbitopathy (GO) based on a systematic review of the literature. We performed a systematic search of OVID MEDLINE, OVID Embase, the Cochrane Central Register of Controlled Trials (CENTRAL) and the publisher subset of PubMed, to identify studi…

BACKGROUND: No optimal therapeutic approach has been established for pemphigus. OBJECTIVE: Our objective was to evaluate the efficacy, steroid-sparing effect, and safety of available treatment modalities. METHODS: PubMed, LILACS (up to July 2014), the Cochrane Central Register of Controlled Trials (CENTRAL, issue 5 o…

OBJECTIVE: To evaluate the efficacy of platelet-rich plasma (PRP) in the treatment of acute wounds. METHODS: Randomized controlled trials (RCT) were identified from PubMed (1950.1-2014.2), Cochrane Central Register of Controlled Trials (CENTRAL, issue 4, 2014) of Cochrane Library, China National Knowledge Infrastructu…

Perioperative corticosteroid administration is a controversial therapy for improving the short-term prognosis following surgery. The objective of the current meta-analysis was to evaluate the effects of the perioperative use of corticosteroids during esophagectomy for esophageal carcinoma. A comprehensive study was per…

This study systematically reviews the randomized clinical trials examining the effect of zinc on attention-deficit hyperactivity disorder (ADHD), searching the PubMed/Medline and Scholar Google databases. All randomized controlled trials that examined zinc as the intervention, and ADHD as the primary outcome were inclu…

The dysregulation of physiological microRNA (miRNA) activity has been shown to play an important role in gliomagenesis. In a previous study, using microRNA arrays and glioma tissues found that miR-27a was upregulated, which was also identified in the glioma cell lines and samples by quantitative real-time polymerase ch…

BACKGROUND: In HIV-infected adults, oral ulcers occur more frequently, last longer and produce more painful symptoms than in immunocompetent people. Oral aphthous ulcers observed during the course of HIV infection may be severe and can result in significant morbidity in these patients. Such manifestations may interfere…

OBJECTIVE: This review provides an update on the cardiovascular impact of therapeutic stimulant-class medication for children and adolescents with attention-deficit/hyperactivity disorder (ADHD). METHOD: Relevant clinical literature was ascertained using PubMed searches limited to human studies and the English languag…

BACKGROUND: The ideal face lift has the longest efficacy, the fewest complications, and ultimately, the highest patient satisfaction. With so many different techniques, there exists a need to make this comparison and to establish which approaches may work best in various groups. To date, there has been no systematic re…

BACKGROUND: Sleep problems are a frequent cause for contacting primary care services. Knowledge of basic mechanisms behind sleep and wakefulness is essential for giving adequate information and correct patients' frequent misperception of sleep. MATERIAL AND METHODS: The present review is based on literature identified…

BACKGROUND: The arterial partial pressure of carbon dioxide (PaCO2) represents the balance between CO2 production and consumption. Abnormal increase or decrease in PaCO2 can affect the body's internal environment and function. Permissive hypercapnia has aroused more attention as a novel ventilatory therapy. The aim of…

BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed psychiatric disorder in children and adolescents with well-known clinical consequences and functional outcomes that affect individuals throughout their lifespan. The diagnosis of adult ADHD is often a clinical diagnosis made on t…

Atrial fibrillation (AF) is the most common sustained rhythm disorder observed in clinical practice and predominantly associated with cardiovascular disorders such as coronary heart disease and hypertension. However, several classes of drugs may induce AF in patients without apparent heart disease or may precipitate th…

Lipoedema is a painful adipose tissue disorder marked by disproportionate limb fat and often misclassified as generalized obesity or lymphoedema. This review examines its metabolic phenotype and implications for cardiometabolic assessment and management. PubMed/MEDLINE was searched from inception through May 2026 for s…

Polynucleotides (PNs) and polydeoxyribonucleotides (PDRNs) are increasingly used in regenerative dermatology; however, randomized evidence across skin rejuvenation, scar prevention, and wound healing has not been comprehensively synthesized. This systematic review evaluated randomized clinical trials investigating PN-…

AIM: The purpose of this systematic review was to investigate the effects of rocker sole shoes on temporal-spatial parameters, kinematics, kinetics, plantar pressure, and electromyography (EMG) activity during walking. METHOD: A systematic search was conducted in the PubMed, Web of Science, Scopus, and Cochrane Centra…

INTRODUCTION/BACKGROUND: Neurosarcoidosis is an uncommon manifestation of systemic sarcoidosis, and isolated cranial nerve involvement is exceptionally rare; therefore, histological biopsy is essential to confirm diagnosis. Isolated trigeminal neurosarcoidosis (TNS), often radiologically mimics common tumors like schwa…

PURPOSE: Endoscopic sinus surgery (ESS) is commonly performed to improve sinonasal complaints and enhance quality of life (QoL) for patients with chronic rhinosinusitis (CRS). Significant research has been published examining the efficacy of ESS in various domains that encompass CRS. METHODS: A systematic search of Pu…