382,819 papers found

Publication bias (PB) poses a significant threat to meta-analysis of diagnostic studies, as studies yielding significant results are more likely to be published in scientific journals, leading to the synthesized diagnostic capacity possibly being overestimated. Sensitivity analysis provides a flexible method to address…

Individualized treatment rules tailor treatments to patients based on clinical, demographic, and other characteristics. Estimation of individualized treatment rules requires the identification of individuals who benefit most from the particular treatments and thus the detection of variability in treatment effects. To d…

INTRODUCTION: Career plateau is a situation that has many negative effects on individual nurses, nursing management and nursing profession. Despite global research examining career plateaus among nurses, a comprehensive data synthesis on its prevalence and influential factors is still missing. The study aims to systema…

Network meta-analysis has emerged as a method for analysing clinical trials, with a large increase in the number of publications over the past decade. Network meta-analysis offers advantages over traditional pairwise meta-analysis, including increased power, the ability to compare treatments not compared in the origina…

To (1) summarize pooled prevalence and incidence rates of concussion by type of sport and (2) synthesize the differences in prevalence or incidence rates of concussion by type of sports in terms of sex, age, type of session, and level of competition.An overview of systematic reviews with meta-analysis.CINAHL, Embase, E…

In recent years, meta-analyzing summary results from multiple studies has become a common practice in genomic research, leading to a significant improvement in the power of statistical detection compared to an individual genomic study. Meta analysis methods that combine statistical estimates across studies are known to…

INTRODUCTION: Care workers play a fundamental role in delivering care services in long-term care institutions. Burnout has been found to have a negative impact on care recipients and organisations providing care. Little is known about the key factors associated with care workers' burnout. This systematic review aims to…

In recent years, much research and many data sources have become digital. Some advantages of digital or Internet-based research, compared to traditional lab research (e.g., comprehensive data collection and storage, availability of data) are ideal for an improved meta-analyses approach.In the meantime, in meta-analyses…

The LFK index has been promoted as an improved method to detect bias in meta-analysis. Putatively, its performance does not depend on the number of studies in the meta-analysis. We conducted a simulation study, comparing the LFK index test to three standard tests for funnel plot asymmetry in settings with smaller or la…

Systematic reviews and meta-analyses have become central in many research fields, particularly medicine. They offer the highest level of evidence in evidence-based medicine and support the development and revision of clinical practice guidelines, which offer recommendations for clinicians caring for patients with speci…

BACKGROUND: Rosacea is a chronic inflammatory disease usually associated with persistent erythema and periodic flushing. This disease is difficult to treat, and the outcomes are often unsatisfactory and prone to recurrence. In recent years, botulinum toxin has been used as a new treatment for rosacea; however, its effi…

Science is justly admired as a cumulative process ("standing on the shoulders of giants"), yet scientific knowledge is typically built on a patchwork of research contributions without much coordination. This lack of efficiency has specifically been addressed in clinical research by recommendations against avoidable res…

BACKGROUND: Meta-analysis of related trials can provide an overall measure of safety-signal accounting for variability across studies. In addition to an overall measure, researchers may often be interested in study-specific measures to assess safety of the product. Likelihood ratio tests (LRT) methods serve this purpos…

OBJECTIVE: This article describes GRADE guidance for assessing imprecision when rating the certainty of the evidence from network meta-analysis. STUDY DESIGN AND SETTING: A project group within the GRADE working group conducted iterative discussions, computer simulations, and presentations at GRADE working group meeti…

Meta-regression can be used to examine the association between effect size estimates and the characteristics of the studies included in a meta-analysis using regression-type methods. By searching for those characteristics (i.e., moderators) that are related to the effect sizes, we seek to identify a model that represen…

BACKGROUND: In meta-analysis, the normal distribution assumption has been adopted in most systematic reviews of random-effects distribution models due to its computational and conceptual simplicity. However, this restrictive model assumption is possibly unsuitable and might have serious influences in practices. METHOD…

Appropriate handling of aggregate missing outcome data is necessary to minimise bias in the conclusions of systematic reviews. The two-stage pattern-mixture model has been already proposed to address aggregate missing continuous outcome data. While this approach is more proper compared with the exclusion of missing con…

Diagnostic test accuracy studies frequently report on sensitivities and specificities for more than one threshold of the diagnostic test under study. Although it is obvious that the information from all thresholds should be used for a meta-analysis, in practice, frequently, only a single pair of sensitivity and specifi…

BACKGROUND: Evidence from meta-analyses has been influential in deciding whether or not limiting saturated fat intake reduces the incidence of cardiovascular disease. Recently, random effects analyses have been criticised for exaggerating the influence of publication bias and an alternative proposed which obviates this…

BACKGROUND: Several significant issues on clinical trials reporting the effect of arginine-containing dental products have been addressed in systematic reviews and meta-analyses identifying the need for high-quality randomized clinical trials. A further methodological analysis of the given systematic reviews with meta-…