11,611,130 papers found

Alcohol use disorder (AUD) and depressive disorders often co-occur. Findings on the effects of major depressive disorder (MDD) or depressive symptoms on posttreatment alcohol relapse are controversial. The study's aim is to examine the association of MDD and depressive symptoms with treatment outcomes after residential…

BACKGROUND: Damage to the genitourinary supports from repeated pregnancies and labour is the most important predisposing aetiological factor in genital prolapse, a chronic gynaecological disorder that causes distressing morbidity (stress urinary incontinence, micturitional difficulties and problems of defecation). OBJ…

Complexities in the diagnosis and treatment of late-life depression have stimulated various strategies for assisting the primary care physician to fulfil these tasks more effectively. The role of Health Specialist was developed for this purpose in a study to reduce suicidality among older depressed patients. This role…

Dendritic cells (DCs) belong to the immune system and are particularly studied for their potential to direct either an activated or tolerogenic immune response. The roles of microRNAs (miRNAs) in posttranscriptional gene expression regulation are being increasingly investigated. This study's aim is to evaluate the miRN…

OBJECTIVE: To assess the knowledge and confidence levels in emergency management and disaster preparedness among nurse leaders, and to provide recommendations for enhancing nurse leader preparedness. BACKGROUND: The COVID-19 pandemic exposed significant gaps in disaster preparedness among healthcare leaders, including…

It is essential to determine moral intelligence and spiritual caregiving levels among nursing students, who are professionals of the future, for delivering nursing care within a holistic framework and increasing the quality of their delivered care. The present research was conducted to determine the relationship b…

OBJECTIVE: There's a need to highlight prognostic factors (PFs) determining hearing preservation in cochlear implantation (HPCI), as currently there is large variability in outcomes. Given the potential benefits of HPCI, it is important to understand the factors influencing this variation. We apply a novel methodology…

Electronic cigarette (e-cig) use in pregnancy is common, but potential effects on fetal development are largely unknown. This study's goal was to examine the association between e-cig exposure and fetal growth. Data were extracted from medical charts in this single-site retrospective study. The sample, excluding those…

BACKGROUND: Geographic trends in antibiotic prescribing show regional variation in antibiotic overuse and antimicrobial resistance, posing a threat to global health care systems. This study's objective was to examine interprovincial variation in outpatient antibiotic dispensing in Canada in 2019. METHODS: We conducted…

Gastric cancer (GC) is the fifth most frequent malignancy worldwide and the third leading cause of cancer-associated mortality. The study's goal was to construct a predictive model and nomograms to predict the survival of GC patients. This historical cohort study assessed 733 patients who underwent treatments for GC. T…

Worldwide, colorectal cancer is one of the most prevalent malignancies. Due to oncological safety concerns, data regarding the laparoscopic surgical treatment of rectal cancer is scarce. Our study's main aim was investigate the oncological adequacy of laparoscopic surgery in the treatment of rectal cancer by comparing…

BACKGROUND: Corneal transplantation is one of the surgical procedures most frequently performed worldwide and with better prognosis. Among its main indications include: keratoconus, bullous keratopathy, previous graft rejection, corneal dystrophy, and infection. The known risk factors for graft rejection are: recipient…

The use of thickened liquids is a common compensatory strategy to improve swallow safety. The purpose of this study was to determine the optimal liquid viscosity to use to promote successful swallowing in a specific subset of dysphagic patients who swallow puree without aspiration but thin liquid with aspiration. A ref…

OBJECTIVE: The study's purpose was to describe the range of knowledge pertaining to the Bobath (NDT) concept in adult neurological rehabilitation, synthesizes the findings, identify knowledge gaps and develop empirically based recommendations for future research. METHODS: A scoping review of research and non-research…

BACKGROUND: Research in psychotherapy has underscored the importance of therapeutic relationships, especially alliances between therapists and clients, in predicting outcomes. A strong alliance enhances results and reduces dropout. We developed a training program to strengthen alliances, based on a North American super…

During breastfeeding, the human breasts secrete three different kinds of milk. Research indicates that newborns exposed to organochlorine pesticides (OCPs) during developmental stages, even at low concentrations, may suffer irreparable harm. The study aimed to ascertain whether OCPs levels in human milk vary across lac…

This study describes the main characteristics of ongoing observational studies on Alzheimer's disease (AD) to help identify any important research gaps. A search through the WHO International Clinical Trials Registry Platform and on the Primary Registries was conducted on 9 June 2012. The descriptors 'recruiting' or 'o…

BACKGROUND: Sedentary behavior, cardiorespiratory fitness, cognition and age are interrelated and associated with cardiovascular function. No study, however, has specifically evaluated the independent and combined associations of cardiorespiratory fitness and sedentary behavior on cognition, which was this study's purp…

This study uses novel data on multiple childcare types from both kin and nonkin in two culturally similar communities with varying market integration. It tests the hypothesis that market integration is associated with reduced kin support. Who provides support and the type of support vary by level of market integration.…

The current study on the oncologic importance of the lateral margin in buccal cancer makes an important contribution to oral oncology. The present research, particularly examined 216 individuals, stresses the prognostic importance of the lateral margin, identifying it as a crucial but hitherto overlooked driver of recu…