11,356,020 papers found

The study's aim was to evaluate the impact of an in-service training course and supervision of physicians and nurses in terms of quality of care on intra-hospital mortality. The study included 2 cohorts of children. Cohort 1 included 414 children from 0 to 15-years-old who were followed in the paediatric wards of the p…

Due to the continuing prevalence of adolescent substance abuse, promising treatment models need to be developed and evaluated. Thus, the purpose of this study was to evaluate the efficacy of two promising models, Strengths Oriented Family Therapy (SOFT) and The Seven Challenges(R) (7C). Adolescents who qualified for ou…

OBJECTIVE: To investigate the relationship between blood alcohol concentration (BAC) and severity of neurological impairment. DESIGN: Retrospective cross-sectional study. PARTICIPANTS: Subjects with traumatic spinal cord injury (SCI; N = 119) with dates of injury between 1991 and 2000 who received their acute treatme…

Controlled clinical trials in cardiovascular disease are the cornerstone for therapeutic advances in this field of medicine. Since the introduction of the concept of controlled clinical trials there has been substantial progress in the design, conduct, and analysis of such studies. A growing awareness of ethical issues…

Studies have shown that school-based sexual health promotion interventions can improve adolescent sexual and reproductive health outcomes. However, there has been insufficient evidence on the cost and cost-effectiveness of such programmes, driving poor and inconsistent investment and prioritization. This paper analyses…

BACKGROUND: The normal aging process affects many human functions profoundly. The voice is no exception, and some aging effects on the voice are obvious including vocal fold atrophy, bowing, stiffness, more prominent vocal fold processes, and glottic insufficiency. The study's primary aim was to determine the correlati…

BACKGROUND: Few studies in epidemiology have evaluated the effects of gene-environment interaction on oxidative stress, even though this interaction is an important etiologic factor in lung carcinogenesis. We investigated the effects of the genetic polymorphisms of paraoxonase 1 (PON1), smoking, and the interaction bet…

Molecular mechanisms of cerebral vasospasm after subarachnoid hemorrhage (SAH) include specific modes of cell signaling like activation of nuclear factor (NF)-kappaB and vascular cell adhesion molecules (VCAM)-1 expression. The study's hypothesis is that cisternal cerebral spinal fluid (CSF) from patients after SAH may…

BACKGROUND/AIM: Human tears contain hundreds of proteins that may exert a significant influence on tear film stability, ocular surface integrity, and visual function. The authors hypothesise that many of these proteins originate from the meibomian gland. This study's aim was to begin to develop the proteomic methodolog…

BACKGROUND: The Sustaining Health by Integrating Next-generation Ecosystems (SHINE) Study was developed as a data platform that incorporates personal health records (PHRs) into health-related data at the municipal level in Japan. This platform allows analyses of the associations between PHRs and future health statuses,…

Patients with borderline personality disorder (BPD) suffer from a variety of affective symptoms, including emptiness. Emptiness has received less attention, yet causes severe suffering and impairment. This study's primary aim was to compare the severity of emptiness over time in 290 patients with BPD to 72 patients wit…

The role of the enzyme hexokinase 2 in many cancers has been identified through increased glycolysis or binding to the pro-apoptotic channel located in the outer mitochondrial membrane, (VDCA1) and protein kinase (MTOR). To prevent the cancer-causing pathways of this enzyme, it is possible to disrupt the interaction of…

BACKGROUND AND OBJECTIVES: Platelet transfusions are increasing with medical advances. Based on FDA criteria, platelet units are assessed by in vitro measures; however, it is not known how platelet processing and storage duration affect function in vivo. Our study's aim was to develop a novel platelet transfusion model…

Failure mode and effect analysis (FMEA) is a leading tool for risk management in health care. The term "blanket" approach FMEA describes a comprehensive simultaneous look at the variety of interrelated factors that may directly and indirectly affect patient safety. Applying FMEA with the "blanket" approach is not commo…

BACKGROUND: The physical benefits for patients who spend time with a therapy dog have been reported, including decreased anxiety. Pet therapy has decreased anxiety in various hospitalized patient populations. The human-animal bond is the foundation for the positive interaction therapy dogs create. AIMS: This study's p…

OBJECTIVES: This systematic and meta-analysis review was conducted to determine the status of Iranian children and adolescents' physical activity. CONTENT: All the related articles which were published in the major databases, including Pubmed, Scopus, Web of Science, Embase, Magiran, SID from the beginning o…

Unconventional oil and gas (UOG) extraction (fracking) has increased in the United States, as well as interest in the associated risks and benefits. This study’s purpose was to qualitatively examine residents’ perceptions about UOG development in their community. Fifteen interviewees involving residents o…

Whether employees with disabilities disclose their disability in the workplace significantly influences their success, job continuity, and ability to access the benefits provided by their employers significantly. This study explores the challenges and procedures associated with disability disclosure and providing workp…

This letter addresses the manuscript titled "Comparison of Prestroke Frailty and Disability for Outcome Prediction in Older Stroke Patients" by Paola Forti et al. The study explores the predictive role of prestroke frailty in stroke outcomes for older patients, demonstrating its potential to guide clinical decision-mak…

Taiwan’s dengue cases vary annually, peaking in infrequent epidemics, which differ substantially from the Global Burden of Disease Study’s (GBD’s) projections. Although the GBD study provides invaluable insights into global health trends, its modelling approach fails to capture the dynamic change o…