5,008,125 papers found

BACKGROUND: Perioperative oxygen is routinely used, but evidence of its clinical impact remains inconsistent, leading to variable practice. The aim of this work was to provide a comprehensive overview of the effectiveness of perioperative oxygen therapy strategies. METHODS: We searched multiple databases for systemati…

INTRODUCTION: This systematic review and meta-analysis aims to investigate the mutual impact of COVID-19 and psoriasis to inform clinical practice and future research. METHODS: We followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis protocol for systematic reviews and searched PubMed, Web of…

OBJECTIVES: Self-management support aims to give people with chronic disease confidence to actively manage their disease, in partnership with their healthcare provider. A meta-review can inform policy-makers and healthcare managers about the effectiveness of self-management support strategies for people with type 2 dia…

OBJECTIVES: To summarise and synthesise the current evidence regarding the effectiveness of drug interventions to prevent sudden cardiac death (SCD) and all-cause mortality in patients with heart failure with reduced ejection fraction (HFrEF). DESIGN: Overview of systematic reviews. DATA SOURCES: MEDLINE, Embase, ISI…

BACKGROUND CONTEXT: In 2008, the Bone and Joint Decade 2000 to 2010 Task Force on Neck Pain and Its Associated Disorders recommended patient education for the management of neck pain. However, the effectiveness of education interventions has recently been challenged. PURPOSE: To update the findings of the Bone and Joi…

BACKGROUND: High tibial osteotomy (HTO) is a well-recognized procedure for its effectiveness in treating symptomatic early knee arthritis and malalignment. Although there are numerous systematic reviews evaluating the management and outcomes after HTO, there are few investigations on complications of this procedure. P…

BACKGROUND: Many current research needs can only be addressed using very large cohorts. In such studies, traditional one-on-one phone, face-to-face, or paper-based engagement may not be feasible. The only realistic mechanism for maintaining engagement and participation at this scale is via digital methods. Given the su…

OBJECTIVES: Explicit reporting of absolute measures is important to ensure treatment effects are correctly interpreted. We examined the extent to which authors report absolute effects for patient-important outcomes in abstracts of systematic review (SR). STUDY DESIGN AND SETTING: We searched OVID MEDLINE and Cochrane…

BACKGROUND: Remifentanil patient-controlled analgesia (PCA) has emerged as an important option for labour analgesia, particularly for women who are unable to receive neuraxial analgesia. Concerns about maternal safety and staffing requirements suggest that in many maternity units, it is only infrequently used, leading…

OBJECTIVE: Post-stroke dysphagia is a common swallowing disorder that occurs after a stroke, leading to an increased risk of aspiration pneumonia and malnutrition. There is a pressing need for effective and safe interventions for its rehabilitation. This review aims to answer two key scientific questions: (1) What is t…

BACKGROUND: Stem cell therapy (SCT) has emerged as a potential therapeutic avenue, with various cell types being explored for their efficacy in treating dilated cardiomyopathy (DCM). However, the safety and efficacy of these therapies have been the subject of numerous systematic reviews. This umbrella review aims to co…

AIM: The primary aim of the European Society of Coloproctology (ESCP) Guideline Development Group (GDG) was to produce high-quality, evidence-based guidelines for the management of cryptoglandular anal fistula with input from a multidisciplinary group and using transparent, reproducible methodology. METHODS: Previousl…

PURPOSE: Age-related macular degeneration (AMD) is a leading cause of blindness, particularly in higher-income countries. Although dry AMD accounts for 85% to 90% of AMD cases, a comprehensive understanding of the global dry AMD burden is needed. METHODS: A targeted literature review was conducted in PubMed, MEDLINE,…

BACKGROUND: Chronic disease represents a significant burden to the United States (US) health care system, with approximately 50% of all adults in the US having one or more chronic disease conditions. Pharmacist-led chronic disease management interventions are of special interest since 80% of medical treatments involve…

Despite more than a half century of "safe" cardiopulmonary bypass (CPB), the evidence base surrounding the conduct of anticoagulation therapy for CPB has not been organized into a succinct guideline. For this and other reasons, there is enormous practice variability relating to the use and dosing of heparin, monitoring…

High-quality systematic reviews and meta-analyses are essential for translating evidence into practice. We conducted an umbrella review to evaluate the methodological quality of systematic reviews and meta-analyses published in the field of behaviour analysis up to and including 2023. Eligible studies were identified t…

BACKGROUND: Periodontal disease (PD) is a prevalent chronic inflammatory condition linked to cardiovascular disease, diabetes mellitus and dementia, yet it is unclear how far medical specialty guidelines translate this evidence into concrete recommendations for assessment, referral and shared care. OBJECTIVE: To map c…

OBJECTIVE: This study combines a bibliometric analysis with an umbrella review to delineate the research landscape, hotspots, and emerging trends in the application of artificial intelligence to the clinical diagnosis and treatment of mild cognitive impairment. METHODS: We searched the Web of Science Core Collection f…

INTRODUCTION: Kidney stones represent a significant health burden due to their high prevalence, recurrence, and associated healthcare costs. Medical interventions are crucial for preventing and treating kidney stones, especially for patients at high risk or those undergoing extracorporeal shock wave lithotripsy (SWL).…

AIMS: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition marked by chronic pain and voiding dysfunction, often without a clear cause. Management of which often requires a multidisciplinary approach, as well as multiple therapeutic interventions. METHODS: This review characterizes mechanisms an…