42,378 papers found

BACKGROUND: Low back pain is a disability that occurs worldwide. It is a heterogeneous disorder that affects patients with dominant nociceptive, neuropathic, and central sensitization pain. An important pathophysiology of low back pain involves pain sensitization. Various nonoperative interventions are available for tr…

BACKGROUND: This meta-analysis was conducted to compare the therapeutic effect and safety of subthreshold micropulse laser (SML) vs photodynamic therapy (PDT) in treatment of chronic central serous chorioretinopathy (cCSC). METHODS: PubMed, EMBASE, and the Cochrane Library were searched for all relevant studies publis…

BACKGROUND: Keratoconus is a degenerative condition of the cornea that profoundly affects vision and vision-specific quality of life. The axial cornea thins and protrudes, resulting in irregularity and, eventually, scarring of the cornea. There are multiple options available for treating keratoconus. Intrastromal corne…

ETHNOPHARMACOLOGICAL RELEVANCE: Viscum album L., commonly known as mistletoe, has been used for centuries in traditional medicine to treat various neurological diseases, including epilepsy, hysteria, nervousness, hysterical psychosis, dizziness and headaches. AIM OF THE STUDY: The aim of this review is to summarize ex…

OBJECTIVE: A systematic review was conducted to address this clinical question: Does consumption of (non-dairy) sugar-containing beverages (SCBs) among children under age 12 result in excess weight gain? METHODS: The authors searched four databases for controlled trials (randomized and non-randomized) and cohort studi…

INTRODUCTION: This drug safety review provides an update on the long-term cardiovascular risks of therapeutic stimulant class medication for children and adults with attention-deficit/hyperactivity disorder (ADHD). AREAS COVERED: Relevant literature on the long-term (defined as ≥ 12 months) cardiovascular effec…

OBJECTIVE: To estimate the accuracy of pelvic magnetic resonance imaging (MRI) in the diagnosis of deeply infiltrating endometriosis (DIE). METHODS: A comprehensive search of the Medline, Pubmed, Lilacs, Scopus, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Biomed Central, and ISI Web of Science da…

OBJECTIVE: To perform a comprehensive molecular pathways analysis of genes identified through genome-wide expression profiling and the published literature for chronic sinusitis with polyps. STUDY DESIGN: Molecular pathways analysis. SETTING: Academic medical center. METHODS: A molecular pathways analysis of gene bi…

OBJECTIVE: This scoping review will map the existing literature on neurophysiological measures used to assess exercise-induced fatigue in athletes. INTRODUCTION: Exercise-induced fatigue, defined as a transient reduction in physical performance resulting from central and peripheral mechanisms, is a critical factor inf…

BACKGROUND AND OBJECTIVE: Cough is an essential defensive reflex that plays a critical role in airway protection. Dysfunction of this reflex, often manifesting as chronic cough or cough hypersensitivity, involves complex alterations in both peripheral and central nervous systems. While previous studies primarily focuse…

INTRODUCTION: Central nervous system (CNS) drug development remains challenging because effective delivery across the blood-brain barrier (BBB) is difficult to predict preclinically.BBB models are increasingly used to evaluate barrier properties and drug transport, but platform variability and limited standardization h…

INTRODUCTION: Tibial osteomyelitis is a serious condition, often resulting from trauma or orthopedic surgery, frequently requiring soft tissue reconstruction after debridement. This systemic review and meta-analysis compared outcomes of muscle versus fasciocutaneous flap reconstruction following debridement of tibial o…

BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare intracranial tumor, and even rarer when the lesion involves the ventricles. This article aims to evaluate the clinical features of PCNSL lesions involving the ventricles. METHODS: Gathering data from a single institution, we conducted a retrospectiv…

OBJECTIVE: To describe the clinical characteristics, therapeutic approaches, and prognostic outcomes of osmotic demyelination syndrome (ODS) in cancer patients. METHODS: A comprehensive literature search (January 1950-March 2024) using PubMed, Embase, Cochrane Library, and Web of Science. Keywords included "osmotic de…

OBJECTIVE: To investigate, through a systematic review of the literature, whether there are differences in the results of otoacoustic emissions suppression tests in individuals with and without central auditory processing disorder. METHODS: Searches were carried out in the scientific databases Latin American and Carib…

BACKGROUND: Plants of the genus Ferula have long been used to treat neurological diseases such as Alzheimer's disease (AD), pain, depression, and seizures. The main compounds include coumarins, monoterpenes, sulfide compounds, and polyphenol compounds, which can improve the functioning of the nervous system. OBJECTIVE…

OBJECTIVE: The purpose of this study was to evaluate the role of anti-vascular endothelial growth factor (anti-VEGF) treatment on the functional and structural parameters of chronic central serous retinopathy (CSR). METHODS: PubMed was used to systematically review literature published from 1 January 2009 to 1 July 20…

BACKGROUND: Occlusion can be viewed as the most sensitive susceptor of the central nervous system in the oro-facial region. Its inalienable relationships to the temporomandibular joint, the muscles, the stomatognathic system and even the central nervous system are self-evident. Almost all the dental treatments inevitab…

BACKGROUND: Interposition arthroplasty of the first MTP joint has recently experienced renewed interest as a treatment for hallux rigidus. The purpose of this study was to systematically review the rapidly expanding literature on PRO following interposition arthroplasty of the first MTP joint. METHODS: PubMed Central,…

INTRODUCTION: Pain can affect people regardless of age, gender or ethnicity. Chronic central neuropathic pain (CCNP) is a debilitating condition that affects populations such as stroke survivors, amputees, spinal cord injury patients and patients with multiple sclerosis, with prevalence rates between 30% and 80%. This…