5,084,806 papers found

The Gleason grading system was developed in the late 1960s by Dr. Donald F. Gleason. Due to changes in prostatic adenocarcinoma (PAC) detection and treatment, newer technologies to better characterize prostatic pathology, subsequently described variants of PAC and further data relating various morphologic patterns to p…

The idiopathic Parkinson syndrome (IPS) affects multiple structures of the central nervous system and exhibits a broad variety of clinical symptoms that are only partially treatable by pharmacological treatment. Therefore, non-pharmacological approaches are highly warranted. The aim of this study was to identify, categ…

High-quality systematic reviews and meta-analyses are essential for translating evidence into practice. We conducted an umbrella review to evaluate the methodological quality of systematic reviews and meta-analyses published in the field of behaviour analysis up to and including 2023. Eligible studies were identified t…

BACKGROUND: The exponential growth of biomedical literature-over a million new PubMed entries each year-has outpaced traditional evidence-synthesis methods. Systematic reviews, long the cornerstone of evidence-based dentistry, are resource-intensive and often outdated within a few years, widening the gap between curren…

BACKGROUND: Periodontal disease (PD) is a prevalent chronic inflammatory condition linked to cardiovascular disease, diabetes mellitus and dementia, yet it is unclear how far medical specialty guidelines translate this evidence into concrete recommendations for assessment, referral and shared care. OBJECTIVE: To map c…

OBJECTIVE: This study combines a bibliometric analysis with an umbrella review to delineate the research landscape, hotspots, and emerging trends in the application of artificial intelligence to the clinical diagnosis and treatment of mild cognitive impairment. METHODS: We searched the Web of Science Core Collection f…

INTRODUCTION: Kidney stones represent a significant health burden due to their high prevalence, recurrence, and associated healthcare costs. Medical interventions are crucial for preventing and treating kidney stones, especially for patients at high risk or those undergoing extracorporeal shock wave lithotripsy (SWL).…

AIMS: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition marked by chronic pain and voiding dysfunction, often without a clear cause. Management of which often requires a multidisciplinary approach, as well as multiple therapeutic interventions. METHODS: This review characterizes mechanisms an…

Does the use of mouthguards (MGs) effectively prevent dentofacial injuries in athletes? Research Protocol: An umbrella review of systematic reviews (SRs) with or without meta-analyses was conducted. The study followed the Preferred Reporting Items for Overviews of Reviews guidelines, and the AMSTAR 2 tool was used for…

BACKGROUND: Pouch disorders are common and may present with symptoms of increased stool frequency, urgency, incontinence, pelvic cramping, obstructed defecation, and perianal drainage, which can result in poor sleep, fatigue, and disability. This topical review aims to offer expert consensus practice recommendations fo…

The ability of oats to reduce blood cholesterol is well established but there is increasing evidence that its health benefits extend well beyond that. The purpose of this review was to critically evaluate the state of the science of oats in relation to all-cause mortality, cardiovascular and diabetes risk and the effec…

PURPOSE: To summarize and analyze all the evidence available concerning marginal bone loss (MBL) and implant failure between tilted and axial implants. MATERIALS AND METHODS: An electronic literature search was conducted without any language restrictions, and only systematic reviews with meta-analysis or meta-analysis…

BACKGROUNDS & AIMS: The nutritional evaluation of pancreatic cancer (PC) patients lacks a gold standard or scientific consensus, we aimed to summarize and systematically evaluate the prognostic value of nutritional screening and assessment tools used for PC patients. METHODS: Relevant studies were retrieved from major…

INTRODUCTION: Aneurysmal subarachnoid hemorrhage (SAH) is a subtype of hemorrhagic stroke with thirty-day mortality as high as 40%. Given the expansion of Machine Learning (ML) and Artificial intelligence (AI) methods in health care, SAH patients desperately need an integrated AI system that detects, segments, and supp…

Even prior to the COVID-19 pandemic, rates of ambulatory surgeries and ambulatory patients presenting with substance use disorder were increasing, and the end of lockdown has further catalyzed the increasing rates of ambulatory patients presenting for surgery with substance use disorder (SUD). Certain subspecialty grou…

BACKGROUND: Breast implants are the most commonly used medical devices in plastic surgery, and capsular contracture (CC) is one of the most common complications. However, our assessment of CC is based largely on Baker grade, which is problematically subjective and affords only four possible values. METHODS: The author…

This review of systematic reviews of randomized clinical trials summarized the available evidence regarding the effectiveness and safety of interventions to treat depression and/or anxiety in people with type 1 and type 2 diabetes. The sources of information searched were the Cochrane Library, MEDLINE, EMBASE, Web of S…

BACKGROUND: Electronic health records (EHRs) collate longitudinal data that can be used to facilitate large-scale research in patients with cirrhosis. However, there is no consensus code set to define the presence of cirrhosis in EHR. This systematic review aims to evaluate the validity of diagnostic coding in cirrhosi…

The purpose of this paper is to describe all available evidence on the distinctive features of a group of 4 life-threatening acute aortic pathologies gathered under the name of acute aortic syndrome (AAS). The epidemiology, diagnostic strategy, and management of these patients has been updated. The authors propose a ne…

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general…