4,952,678 papers found

BACKGROUND: The National Information Service of the General Practice Evaluation Program (GPEP) produced publications relating to research undertaken under the auspices of the program with the view to adding value to such research. Two anthologies of literature reviews from GPEP research have been produced, one in 1998…

Persistent androgen signaling is functionally significant in castration-resistant prostate cancer (CRPC) and it is actually considered a validated therapeutic target. Residual intra-tumoral androgens compensate for the effects of androgen ablation, activating the androgen receptor (AR), AR-mediated gene expression and…

BACKGROUND: High-quality review evidence is useful for informing and influencing public health policy and practice decisions. However, certain topic areas lack representation in terms of the quantity and quality of review literature available. The objectives of this paper are to identify the quantity, as well as qualit…

CONTEXT: Systematic review evidence is increasing within craniofacial surgery. Compliance with recognised reporting guidelines for systematic review evidence has not been assessed. OBJECTIVE: To assess the compliance of systematic reviews published in craniofacial journals with the Preferred Reporting Items for System…

We review a decade of review articles concerning psychosocial interventions for cancer patients. We find a distinct progression in the tone of interpretations of the literature, as better quality studies accumulate and the sophistication of reviews improves. The current literature does not make a compelling case for th…

INTRODUCTION: In the U.K. more than 40,000 people are diagnosed with lung cancer every year and an estimated 65,000 people are living with lung cancer. The most effective follow-up strategy for these patients is undetermined. This article reports a systematic review of studies comparing different follow-up strategies f…

Epileptic nystagmus (EN) is characterized by repetitive eye movements as a symptom of seizure activity. Two cases of EN are reported including ictal EEG, video recordings and MRI. In addition, we review the published cases and pathophysiological background of EN. The cardinal cortical region for EN is located at the ju…

BACKGROUND: Prospective payment systems are widely used in OECD countries and beyond to reimburse hospital care. OBJECTIVE: To evaluate the impact of prospective payments systems on the quality of patient care, healthcare efficiency, volume of activity, and hospital costs. METHODS: Umbrella review by searching three…

OBJECTIVE: Little is known about the barriers, facilitators and interventions that impact on systematic review uptake. The objective of this study was to identify how uptake of systematic reviews can be improved. SELECTION CRITERIA: Studies were included if they addressed interventions enhancing the uptake of systemat…

BACKGROUND: Relatively little is known of the use of systematic review and synthesis methods of non-randomised psychiatric epidemiological studies, which play a vital role in aetiological research, planning and policy-making. AIMS: To evaluate reviews of psychiatric epidemiological studies of functional mental disorde…

RATIONALE: Ubiquitous devices such as smartphones, wearables, and personal gadgets generate large volumes of personalized health data outside of traditional health systems. Despite its abundance, differences in data formats and semantics across hardware, platforms and sectors keep information siloed. As a result, valua…

OBJECTIVE: The aim of this study was to report clinical treatment recommendations for low back pain (LBP) based on 5 international guidelines and best evidence from the Cochrane database of systematic reviews. METHODS: Five LBP guidelines available in English language were appraised, including 4 studies published sinc…

BACKGROUND: Next to the school environment, the family and community environment are key for young people's behaviour and for promoting physical activity (PA). METHODS: A review of reviews was conducted, after which a literature search was conducted (in PubMed, Scopus and PsychInfo) from August 2007 (search date of th…

BACKGROUND: The inappropriate and inconsistent selection of primary outcomes (POs) in randomised controlled trials (RCTs) and systematic reviews (SRs) can make evidence difficult to interpret, limiting its usefulness to inform clinical practice. OBJECTIVES: To systematically review the choice and consistency of POs in…

The peer review process is integral to the functioning of all scientific journals and plays a pivotal role in the publication of new scientific material. Timeliness, freedom from bias, and proper review etiquette are essential for an effective review. Each type of scientific article demands a slightly different reviewi…

Head and neck cancer is one of the leading causes of deaths worldwide. Two genes GSTM1 and GSTT1 involved in phase II of carcinogen detoxification have been frequently studied in the literature. Their null genotypes are thought to be associated with increased head and neck cancer risk. However, the published reviews ar…

OBJECTIVES: The objective of this paper is to describe the main steps and to conduct a systematic literature review on preventive interventions concerning work-related injuries and to illustrate the process. METHODS: Based on the Cochrane handbook, a structured framework of six steps was outlined for the development o…