382,401 papers found

The benefits of statins in patients with stable coronary syndrome is indisputable, however their early use in acute coronary syndrome (ACS) is under debate. There are few existing clinical trials and meta-analysis results on this and their results provide little clarification. However, most of the registries have found…

Currently, the challenge is to analyze and synthesize as much information as possible in order to make quick, correct decisions. Systematic reviews and meta-analysis have quickly arisen in the health field because they allow researchers to congregate studies of similar characteristics to generate estimators that descri…

The authors reviewed studies on college students' physical activity (PA) behaviors and found that previous research on this topic focused on describing college students' PA patterns and their determinants. Researchers reported that about 40% to 50% of college students are physically inactive. More important, health and…

The present article reviews recent studies of 'healthy aging' with and without cardiovascular risk factors and accompanying white matter changes. Specifically, the relationship between white matter hyperintensities (WMH) and various cognitive functions, in particular executive functions (EF), was subjected to meta-anal…

Coronary artery disease remains a common problem in industrialized countries. Percutaneous coronary interventions are usually performed utilizing the femoral approach. Arterial puncture-closing devices have been developed in hope to avoid manual compression and shortening the period of rest. In a recent meta-analysis i…

A recent meta-analysis of all randomised trials assessing the efficacy and safety of glycoprotein IIb/IIIa agents with acute coronary syndromes showed that there was a significant interaction with sex. Explaining this difference requires an analysis of whether it has any pathophysiological basis, whether antithrombotic…

Randomised controlled trials have shown that screening may significantly reduce mortality in colorectal cancer. In the present evaluation it is shown that the reported reduction of 15 per cent, or higher, is given in relative figures. With absolute figures the reduction is only 0.15 per cent or lower. The number of ind…

The Cochrane collaboration has performed a meta-analysis of all studies found on the prevention of ankle ligament injuries, frequent in sports like soccer, European handball and basketball. Interventions include the use of modified footwear and associated supports, training programmes and health education. Five randomi…

Evidence of the benefit of exercise for patients with musculoskeletal problems was examined by analysing meta-analyses and systematic reviews. The literature search was confined to studies where pain and/or function was used as the outcome measure. Twenty-three meta-analyses/systematic reviews were covered, and the met…

In response to concerns described by H. N. Garb, J. M. Wood, M. T. Nezworski, W. M. Grove, and W. J. Stejskal (2001), the authors present the weighted and unweighted means and medians of the effect sizes obtained by J. B. Hiller, R. Rosenthal, R. F. Bornstein, D. T. R. Berry, and S. Brunell-Neuleib (1999). These indice…

Doppler ultrasonography was introduced into clinical obstetric practice over 20 years ago. It is also accepted that a variety of common obstetrical complications such as preeclampsia and intrauterine growth restriction have their origin in abnormal development of the placental vasculature and this could be reflected in…

This commentary on J. Archer (2000) identifies limitations at the level of the primary data, the formal meta-analysis, and the interpretations of the results. Highlighted are concerns with the conceptual dichotomy that is the foundation of the analysis, how aggression was conceptualized and defined, and the methodologi…

Studies have evaluated the comparative efficacy, toxicity and costs associated with extended-interval vs. standard multiple daily dosing of aminoglycosides. In this case, an elderly man with diabetes and good renal function at baseline was switched from standard to extended-interval dosing. During the course of therapy…

Many risk factors operate in both coronary heart disease and stroke, especially ischaemic stroke--age, sex, social class, blood pressure, pre-existing vascular disease (angina, myocardial infarction, cardiac failure, diabetes and peripheral vascular disease, transient ischaemic attack and stroke), atrial fibrillation a…

A protocol to prospectively study characteristics of meta-analyses submitted to a weekly medical journal raised several ethical issues. In submitting a manuscript for publication, authors do not implicitly consent to have their work used for research. Authors must be free to refuse to consent, without it affecting thei…

A 33-item measure of homesickness (the Homesickness Questionnaire, HQ) was derived from features of grief modified for the circumstance of separation from home. In three samples of year 1 students (N = 264) during their first year at university, total HQ scores were highly correlated with a single-item measure of homes…

BACKGROUND: Network meta-analysis (NMA) has rapidly grown in use during the past decade for the comparison of healthcare interventions. While its general use in the comparison of conventional medicines has been studied previously, to our awareness, its use to assess complementary and alternative medicines (CAM) has not…

OBJECTIVES: Dose-response meta-analysis (DRMA) is a crucial clinical and epidemiological research tool for synthesizing exposure-risk relationships. Despite its growing use, facilitated by the availability of statistical software, the appropriateness of the underlying statistical methods has not been thoroughly explore…

INTRODUCTION: Perineal trauma is one of the most common complications of childbirth, impacting approximately 9 out of 10 women who undergo a vaginal delivery. Perineal trauma is a public health issue leading to increased maternal morbidity and decreased quality of life. Although race is being studied as a potent…