Prevalence of CYP2D6 structural variation in large retrospective study.
Frear Samantha, Sherman Ashley, Rule Don, +1 more·Pharmacogenetics and genomics
CYP2D6 is a highly polymorphic gene with clinically important structural variations. Commonly, only exon 9 is assayed on clinical pharmacogenomics panels, as it allows for accurate functional characterization even in the presence of a CYP2D6::CYP2D7 conversion. However, this method does not capture CYP2D7::CYP2D6 (CYP2…