5,085,026 papers found

Patients with heart disease, or at high risk of developing a cardiac condition, usually undergo risk assessment by primary care physicians, internal medicine doctors, or cardiologists. There are several methods that can be used for this risk assessment, and their applicability differs with respect to availability, comp…

Suboptimal reporting in the publication of imaging research studies is a growing concern. Deficient and incomplete reporting prevents the evaluation of the validity, replicability, and the overall quality of the research. Reporting guidelines are checklists designed to guide researchers about the minimum information to…

Medical simulation training - an overview of the evidence Medical simulation training has become an important model for training of technical and non-technical clinical skills, aiming at preventing avoidable mistakes. The evidence for effects of simulation training is increasing, and several systematic reviews on the e…

The key health issues for women tend to be primarily associated with the female reproductive system. There are also other gender priorities and consequences associated with ageing, which require effective interventions. Acupuncture is used worldwide and its evidence base is increasing on both mechanisms of action and i…

OBJECTIVE: To evaluate the quality of systematic reviews (SRs) affecting clinical practice in endocrinology. STUDY DESIGN AND SETTING: We identified all SRs cited in The Endocrine Society's Clinical Practice Guidelines published between 2006 and January 2012. We evaluated the methodological and reporting quality of th…

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative condition. Optimal management requires a palliative approach from diagnosis with emphasis on patient autonomy, dignity and quality of life. OBJECTIVE: To conduct a systematic analysis of the type, level and timing of specia…

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with no known effective treatment or cure. Clinicians often expect that ALS patients will experience depression following the diagnosis because ALS is a terminal disease. The objective of the current study was to examine the eviden…

An education program for hospital physicians and family doctors including up to date knowledge on diagnosis, prevention and treatment of venous thromboembolism has been elaborated, chiefly within the framework of hospital consensus conferences. Postgraduate consensus meetings led by representatives of specialities inte…

Before the rise of atypical antipsychotics, lithium used to be the most frequently investigated substance in the acute treatment of bipolar disorders, although studies are not always of the highest methodological standard. Due to the doubt about a sufficient efficacy of lithium expressed in recent years from various si…

Initial therapy for advanced prostate cancer includes androgen ablation by surgical or medical castration. Still, nearly all men with metastases will progress to hormone-refractory prostate cancer (HRPC). Current U.S. Food and Drug Administration-approved agents for the treatment of HRPC include mitoxantrone and estram…

Clinical practice is constantly changing, the rate of changing is accelerating and consequently it may even take years before the results of clinical research will be incorporated in day-to-day practice. So, there is a large gap between what the biomedical literature contains and the care that most of patients receive.…

PURPOSE: To see whether investigators of a circumscribed research topic, the haemodynamic response to orotracheal intubation, review and cite previous work. A 1989 editorial about the response was critical to investigators for measuring physiology but not outcome; for nonetheless making recommendations; for studying on…

OBJECTIVE: The bidirectional communication between the nervous system and the gastrointestinal tract plays a crucial role in maintaining homeostatic balance.The present study aims to understand the gut-brain axis and how this complex interaction relates to inflammatory bowel disease and the development of anxious and d…

BACKGROUND: Workplace heat exposure, intensified by climate change, increasingly threatens workers' health, safety, and productivity, especially in the agriculture, construction, and manufacturing sectors. However, current evidence is fragmented due to varied study designs, and the absence of an integrated, multidiscip…

STATEMENT OF PROBLEM: The accuracy of dental implant placement influences prosthetic outcomes, biological complications, and long-term success. While guided surgery aims to improve precision, its advantages over conventional freehand techniques regarding survival, marginal bone stability, and complications remain uncle…

BACKGROUND: Currently, most studies of depression are limited to a single disease endpoint. AIMS: This study aimed to conduct an umbrella review to comprehensively assess the association between depression and health outcomes. METHOD: Until December 17, 2024, we conducted a systematic search of systematic reviews and…

BACKGROUND: Poly (ADP-ribose) polymerase inhibitors (PARPi) have become a key treatment for ovarian cancer, particularly in patients with BRCA mutations or homologous recombination deficiency (HRD). METHODS: This umbrella review synthesizes findings from 35 systematic reviews and meta-analyses of randomized controlled…

Skin cancer has one of the highest incidence rates among malignancies. A shortage of clinical expertise, particularly in primary care, contrasts with the promising performance of artificial intelligence (AI) models in assisting clinicians. However, a comprehensive evaluation of AI-based diagnostic accuracy across vario…

Extended pelvic lymph node dissection (EPLND) for rectal cancer is common in Asian countries to reduce local recurrence and improve survival. This umbrella review investigates the benefit of adding extended lymphadenectomy to the standard total mesorectal excision (TME) practice. We conducted a comprehensive search of…

BACKGROUND: Conventional treatments for cardiometabolic diseases face limitations related to cost, efficacy, and side effects. Hibiscus sabdariffa (HS) is a common food product and a potential alternative. However, previous studies have shown inconsistent results and lacked assessments of result certainty, intervention…