381,523 papers found

Meta-analysis of gene-based tests using single-variant summary statistics is a powerful strategy for genetic association studies. However, current approaches require sharing the covariance matrix between variants for each study and trait of interest. For large-scale studies with many phenotypes, these matrices can be c…

We develop a nonparametric Bayesian prior for a family of random probability measures by extending the Polya tree ($\mbox{PT}$) prior to a joint prior for a set of probability measures $G_1,\dots ,G_n$, suitable for meta-analysis with event-time outcomes. In the application to meta-analysis, $G_i$ is the event-time dis…

Individual participant data (IPD) meta-analysis projects obtain, harmonise, and synthesise original data from multiple studies. Many IPD meta-analyses of randomised trials are initiated to identify treatment effect modifiers at the individual level, thus requiring statistical modelling of interactions between treatment…

Sporadic adrenocortical tumours are common, but their pathogenesis is poorly elucidated. In this study, we present a meta-analysis and review of gene expression microarray and comparative genome hybridization (CGH) studies performed to date on these tumours, including our own data. Data of whole genome microarray studi…

BackgroundCardioplegic arrest can be induced by various methods, fueling a long-standing controversy about their comparative merit. We aim to compare cardioplegic methods in coronary artery disease.MethodsPubMed, Embase, and Cochrane databases were interrogated for randomized trials that compared various cardioplegic m…

The route of administration significantly influences the pharmacokinetics of progestogens. For luteal phase support (LPS) after fresh embryo transfer in IVF, ESHRE recommends vaginal, intramuscular, subcutaneous progesterone or oral dydrogesterone. This network meta-analysis evaluated the relative effectiveness of prog…

Image-based meta-analysis (IBMA) is a powerful method for synthesizing results from various fMRI studies. However, challenges related to data accessibility and the lack of available tools and methods have limited its widespread use. This study examined the current state of the NeuroVault repository and developed a comp…

Many pharmacologic regimens have been recommended as supplemental treatment strategies for cocaine abuse. Using the technique of meta-analysis, we compared and combined the data from six studies to examine the efficacy of desipramine as an adjunctive treatment approach for cocaine addiction. These studies were randomiz…

A meta-analysis of all controlled clinical trials of beta-adrenoceptor blocking drugs, principally propranolol, in the prevention of primary or secondary variceal bleeding has shown that beta-blockade significantly reduced the occurrence of variceal bleeding, deaths from variceal bleeding, and overall mortality. There…

OBJECTIVE: This study aimed to evaluate the effectiveness of robot-assisted gait training (RAGT) in treating lower extremity function in patients with cerebral palsy (CP) and compare the efficacy differences between different robotic systems. METHODS: PubMed, Web of Science, Cochrane Library, Embase, CNKI, VIP, CBM, a…

PURPOSE: In this study we gathered and analyzed the available evidence regarding 17 different imaging modalities and performed network meta-analysis to find the most effective modality for the differentiation between brain tumor recurrence and post-treatment radiation effects. METHODS: We conducted a comprehensive sys…

BACKGROUND: Dysfunction of the autonomic nervous system (characterized by excessive sympathetic activation and reduced parasympathetic activity) is regarded as 1 of the primary mechanisms of heart failure. Theoretically, nerve stimulation or modulation targeting this autonomic imbalance could improve outcomes in heart…

Data from 75 published trials were analyzed using meta-analysis techniques (pooling of data from many trials into one analysis) to determine nutritional risk factors for milk fever. Trials included in the analysis represented 1165 cows, 214 of which developed milk fever. Prepartum dietary concentrations of S and dietar…

The result of a meta-analysis is conventionally pictured in the forest plot as a diamond, whose length is the 95% confidence interval (CI) for the summary measure of interest. The Diamond Ratio (DR) is the ratio of the length of the diamond given by a random effects meta-analysis to that given by a fixed effect meta-an…

A literature search revealed 22 controlled clinical studies on the efficacy of acupuncture in three fields of addiction: cigarette smoking (15), heroin (five), and alcohol (two). These studies were reviewed using a list of 18 predefined criteria of good methodology. A maximum of 100 points for study design could be ear…

This study quantitatively integrated the results of independent research papers containing correlates of objectively measured diabetes patients' compliance with prescribed medications. A total of 183 correlations were extracted from 26 studies. Separate meta-analytic syntheses were conducted to calculate average correl…