Off-label use of 4-factor prothrombin complex concentrate is common despite little known benefit: A retrospective study.
Scharman Carlton D, Shatzel Joseph J, Kim Edward, +1 more·European journal of haematology
BACKGROUND/OBJECTIVE: While four-factor prothrombin complex concentrate (4F-PCC) is FDA-approved for reversal of warfarin-induced major bleeding, its use in real-world settings is unclear. This study's objective was to identify indications leading to 4F-PCC use and associated outcomes at a single university hospital.…