4,999,347 papers found

Head and neck cancer is one of the leading causes of deaths worldwide. Two genes GSTM1 and GSTT1 involved in phase II of carcinogen detoxification have been frequently studied in the literature. Their null genotypes are thought to be associated with increased head and neck cancer risk. However, the published reviews ar…

PURPOSE OF REVIEW: Oral pain is a common complaint in patients with cancer. This review aims to summarize the knowledge on the causes and approach to management of oral pain garnered over the past 2 years. RECENT FINDINGS: A systematic review and meta-analysis included in the review, assessed cannabinoid versus placeb…

BACKGROUND: Systematic reviews risk producing biased conclusions if a comprehensive search to identify eligible studies is not undertaken, but little evidence exists to guide prioritisation of databases to search when resources are limited. OBJECTIVES: A systematic review examining interventions for managing frozen sh…

RATIONALE: Ubiquitous devices such as smartphones, wearables, and personal gadgets generate large volumes of personalized health data outside of traditional health systems. Despite its abundance, differences in data formats and semantics across hardware, platforms and sectors keep information siloed. As a result, valua…

BACKGROUND: Hypertensive disorders of pregnancy remain a major cause of maternal and perinatal morbidity and mortality worldwide. Calcium supplementation during pregnancy is recommended by guidelines and the World Health Organization to prevent preeclampsia largely based on successive versions of a Cochrane systematic…

Balance impairment is a major motor symptom of Parkinson's disease (PD), leading to falls, reduced mobility, and lower quality of life. Despite advances in pharmacological and rehabilitation approaches, postural instability often persists, requiring effective adjunctive interventions. Vibration therapy (VT) is a non-in…

BACKGROUND AND OBJECTIVES: Evidence syntheses systematically compile and analyze information from multiple sources to support health-care decision-making. As many different types of questions need to be answered in health care, different evidence synthesis types have emerged. In this article, we introduce the most comm…

Systematic reviews seek to bring together research evidence to answer the question for the review. The reviewers usually wish to compare, contrast and, if appropriate, combine the findings of the existing research studies. However, these intentions are often thwarted by inconsistencies in the outcomes that were measure…

As in other disciplines in medicine, systematic reviews (SR) and meta-analyses (MA) in infectious diseases are an important aid to clinical decision-making. In the present article we review features important to SRs in infectious diseases that should be addressed in most SRs and MAs. We stress the need to include in th…

Introduction Professor Archibald Cochrane, after whom the Cochrane Collaboration is named, was influential in promoting evidence-based clinical practice. He called for "relevant, valid research" to underpin all aspects of healthcare. Systematic reviews of the literature are regarded as a high quality source of cumulati…

Systematic reviews have become widely used for evaluating evidence across all fields of biomedicine. The objective of a systematic review is to provide a comprehensive and contemporary appraisal of research using transparent methods whilst aiming to minimize bias. In essence, research methodology is employed in the con…

Systematic reviews aim to systematically identify, critically assess and summarise all relevant studies on a specific topic. The present article gives advice on how to find, assess and exploit systematic review on effectiveness. Systematic reviews on effectiveness constitute a source of knowledge for professionals with…

Research evidence supporting the implementation of centredness in health care is not easily accessible due to the sheer amount of literature available and the diversity in terminology and conceptualisations used. The use of text-mining functions to semi-automate the process of screening and collating citations for a re…