42,426 papers found

: Central nervous system (CNS) involvement in acute myeloid leukemia (AML) is a rare but important complication linked to poor outcomes. Diagnosing it is difficult because neurological symptoms are often subtle or nonspecific, and conventional cytology and imaging have limitations. This review summarizes current eviden…

BACKGROUND: Deep brain stimulation (DBS) significantly improves tremor, rigidity, bradykinesia, and dyskinesia for patients with Parkinson's disease (PD), but gait and speech remain inconsistent. These discrepancies underscore the need for a systematic, quantitative synthesis of existing data to clarify the impact of D…

CONTEXT: Primary central nervous system lymphoma (PCNSL) is a rare malignancy that may involve the hypothalamic-pituitary axis (HPA), leading to underrecognized but clinically significant endocrine dysfunction. OBJECTIVE: To characterize the spectrum and patterns of HPA-related endocrine disturbances in patients with…

CONTEXT: Following the exposure to toxic therapeutic agents employed in the treatment of malignancies, endocrine complications can affect up to 40-60% of childhood cancer survivors (CCS), with central hypothyroidism (CeH) being a relevant adverse event observed in this population. Given the long-standing uptrend in the…

OBJECTIVES: This paper aims to describe the ideal relationship between lips and teeth as 2 critical facial features to guide young doctors keen on lip augmentation. METHODS: The literature survey was performed in PubMed, EBSCO, UpToDate, Proquest Central databases of Kirikkale University, and Google and Google Scholar…

As the first approved GnRH agonist, leuprorelin is distinguished by its broad application in managing central precocious puberty (CPP). Despite the extensive use of leuprorelin in CPP management, uncertainties still persist regarding its long-term efficacy and safety. We conducted a systematic review and meta-analysis…

BACKGROUND: The implanted vascular access ports (PORTs) were compared with peripherally inserted central catheters (PICCs) as the administration of chemotherapy regarding different clinical effects and adverse effects. Which is better is debatable. Hence, the current study was conducted to assess the safety and efficac…

Body-brain interaction provides a novel approach to understand neurodevelopmental conditions such as autism spectrum disorder (ASD). In this systematic review, we analyse the empirical evidence regarding coexisting differences in autonomic (ANS) and central nervous system (CNS) responses to social stimuli between indiv…

Pain is a well-recognized and important non-motor manifestation in Parkinson disease (PD). Painful or unpleasant sensations in PD can be classified as musculoskeletal, dystonia, akathisia, radicular, and central or primary pain; the last two are associated with neuropathic pain. Particularly, neuropathic pain in PD has…

BACKGROUND: Many systematic reviews have focused on assessing the effect of body mass index (BMI) on the outcomes and complications associated with total hip arthroplasty (THA) and total knee arthroplasty (TKA), but primarily dealt with obesity compared to normal weight (NW). None of these reviews attempted to assess t…

OBJECTIVE: To identify central nervous system (CNS) adverse events potentially associated with prophylaxis or drug treatment for COVID-19, and to describe the characteristic of the individuals affected. METHODS: A scoping review was performed using a search strategy to retrieve articles from PubMed, EMBASE, SciELO, Sc…

BACKGROUND: As many inconsistent reports on the clinical manifestations and prognosis between unilateral unifocal PTC (UUPTC) and unilateral multifocal PTC (UMPTC), identifying the difference should guide management. The purpose of this study was to investigate other additional differences between UUPTC and UMPTC in ad…

BACKGROUND: The World Health Organization has identified 17 neglected tropical diseases (NTDs) that disproportionately affect the world's poorest populations. The neurologic aspects of many of these NTDs have received relatively little attention. METHODS: A review was performed in PubMed (MedLine) for each NTD by dise…

RATIONALE: The incidence and patterns of metastatic disease to the central nervous system (CNS) from malignant mesothelioma are not well characterized. OBJECTIVES: We describe the treatment of two cases of pleural mesothelioma with CNS metastases. We also report the results of a systematic review with pooled data anal…

BACKGROUND: Bladder EpiCheck (BE) is a novel methylation-based PCR urine test for the detection of non-muscle invasive bladder cancer (NMIBC) recurrences. OBJECTIVE: We present the results of a North American study evaluating BE and meta-analysis of literature. METHODS: A prospective, blinded, multicenter study was c…

Persistent pain remains a common clinical challenge after hip and knee arthroplasty, even when surgical outcomes are technically successful, with growing recognition that altered central pain processing, particularly central sensitization (CS), may contribute to unfavorable postoperative outcomes. This systematic revie…

Central venous pressure (CVP) is a critical parameter for assessing volume status in critically ill patients, traditionally measured through invasive central venous catheterization. While effective, this method poses risks such as infection and procedural complications. Point-of-care ultrasound (POCUS) has emerged as a…

Currently, there is no summative study evaluating the association between central obesity and screen time. This systematic review and meta-analysis aimed to summarize the results of studies evaluating the association between screen time and central obesity among children and adolescents. To this end, we performed a sys…

BACKGROUND AND OBJECTIVE: Despite Bacillus Calmette-Guerin (BCG) remaining the standard of care for high-risk non-muscle-invasive bladder cancer (HR-NMIBC), novel combination strategies are being actively investigated. Comparative evidence on the efficacy and tolerability of these regimens in BCG-naïve patients re…

BACKGROUND: Postoperative scarring of the face can cause a serious psychological burden on people. Botulinum toxin type A has shown potential effectiveness in preventing scarring after facial surgery. The study aims to evaluate the role of botulinum toxin type A in postoperative scar management. METHODS: We searched P…