5,085,027 papers found

The Amsterdam classification system defines four major patterns of placental injury, maternal vascular malperfusion, fetal vascular malperfusion, acute chorioamnionitis, and villitis of unknown etiology, and lists the histologic findings that characterize each. However, there continues to be uncertainty regarding speci…

Recent terrorist attacks involving active shooters or improvised explosive devices have shown that traditionally sequenced emergency management leads to delays in attending victims and suboptimal outcomes. Tactical medicine, a new concept in prehospital care, emerged from experience attending the wounded in combat zone…

Because surgical procedures require clinicians to develop and maintain procedural expertise and because blinding in randomized clinical trials of such therapies is often challenging, their critical appraisal raises unique issues. Risk of bias of trials of surgical procedures increases if investigators fail to rigorousl…

The present study attempts to critically evaluate previously published research articles on the efficiency of acupuncture in the treatment of diseases. First, 35 systematic reviews or meta-analysis were found in the Cochrane database. Second, 54 related articles were selected by searching important scientific databases…

A decade has passed since the Chicago Consensus meeting was convened to consider how to improve the management of individuals and their families with an intersex disorder. It is apposite to review, from an individual perspective, what impact the Consensus has had on clinical practice and research. Emphasis is placed on…

BACKGROUND: Several systematic reviews of acupuncture as a treatment of insomnia have recently emerged. Their results are far from uniform. AIM: To summarize and critically evaluate these reviews with a view of defining the reasons for their discrepant conclusions and providing an overall verdict about the therapeutic…

Urinary tract infection is one of the most common causes of infection in newborns. Obtaining a urinary tract infections (UTIs) diagnosis just on the basis of the clinical findings is frequently difficult, however, being the pediatrician's goal to reduce the risk of renal scarring, a prompt diagnosis and treatment is of…

Bullying is a problem for schools around the world, and is an important topic for research because it has been associated with negative outcomes on numerous social, psychological, and academic measures. Antibullying prevention and intervention programs have varied greatly in their outcomes, with some studies reporting…

A review of the scientific evidence available on the indications for hospitalization in pediatric patients with urinary tract infection is presented. We found no studies that specifically evaluated the utility of hospitalization in children with urinary tract infection. Only indirect data were found on the identificati…

Patients with osteoarthritis of the knee are commonly treated by physical therapists. Practice should be informed by updated evidence from systematic reviews. The purpose of this article is to summarize the evidence from systematic reviews on the effectiveness of physical therapy for patients with knee osteoarthritis.…

An evidence synthesis of a medical intervention should assess the balance of benefits and harms. Investigators performing systematic reviews of harms face challenges in finding data, rating the quality of harms reporting, and synthesizing and displaying data from different sources. Systematic reviews of harms often rel…

The 6th International conference on Adjuvant Therapy of Primary Breast Cancer was held in St. Gallen, Switzerland in February 1998, and this is an overview of its guidelines. Since 1995, several specific areas have accumulated important new information and were highlighted at the 1998 conference. These include the foll…

BACKGROUND: Despite evidence of the long-term implications of unrelieved pain during infancy, it is evident that infant pain is still under-managed and unmanaged. Inadequately managed pain in infancy, a period of exponential development, can have implications across the lifespan. Therefore, a comprehensive and systemat…

BACKGROUND: Cancers of the oesophagus, gastroesophageal junction (GEJ), and proximal stomach share epidemiological, molecular, and therapeutic characteristics. Despite their similarities, treatment guidelines vary, and the classification of GEJ tumours remains debated. While multiple meta-analyses have addressed subset…

BACKGROUND: Abstracts of systematic reviews and meta-analyses offer an efficient way to digest the full text, however; abstracts that contain spin, defined as reporting greater efficacy or safety of the experimental treatment than is supported by the results, can negatively affect clinical decisions. PURPOSE/HYPOTHESI…

Giant omphalocele management had not reached a consensus from the pediatric surgical perspective regarding conservative treatments, surgical approaches, and clinical outcomes. This topic was therefore selected for the 2023 Consensus Session of the European Paediatric Surgeons' Association (EUPSA).Literature review was…