42,457 papers found

BACKGROUND: Central neck dissection and total thyroidectomy are standard treatments for patients with papillary thyroid carcinoma (PTC) with clinically involved central nodes. However, prophylactic central neck dissection (pCND) in patients with clinically uninvolved cN0 has been beneficial in some studies but ineffect…

BACKGROUND: Tuberculous meningitis (TBM) is a severe extrapulmonary complication of tuberculosis. Early diagnosis is crucial in improving patient outcomes, albeit difficult given the non-specific clinical presentation of early stage TBM. Numerical diagnostic scoring systems may be useful diagnostic tools for clinicians…

This narrative review synthesizes evidence on effective nursing interventions aimed at mitigating the primary psychological challenges, particularly anxiety and depression, faced by patients with colorectal cancer. A literature search of key databases, including PubMed, Web of Science, and Google Scholar, was conducted…

The objective of this research is to identify and systematize the medical conditions generated by SARS-CoV-2 on the optic nerve and retina of young, adult, and elderly adults who suffered from COVID-19 in the period 2019-2022. A theoretical documentary review (TDR) was conducted within the framework of an investigation…

This systematic review was designed to evaluate the efficacy of tubeless percutaneous nephrolithotomy (PCNL) versus standard percutaneous nephrolithotomy (PCNL) for kidney stones. Computerized search was performed for randomized clinical trials (RCTs) from PubMed, EMBASE, CENTRAL and Cochrane Database of Systematic Rev…

OBJECTIVE: The controlling nutritional status score (CONUT) has been utilized for prognostication of several cancers but its utility for hepatocellular carcinoma (HCC) is still unclear. We reviewed evidence on the ability of CONUT to predict overall survival (OS) and disease-free survival (DFS) in patients with HCC. M…

OBJECTIVE: To summarize the current understanding of neuronal intranuclear inclusion disease (NIID) and improve the understanding of the physician about this condition. METHODS: We searched PubMed with keywords related to NIID and selected publications which seemed appropriate. We analyzed its clinical features, patho…

OBJECTIVE: The purpose of the paper is to examine the current state of the art about epidemiology, diagnosis, and treatment of this infection. METHODS: A review of the literature was performed through a PubMed search of original articles, case reports, and reviews using the key words "brain abscess," "cerebral abscess…

Tinnitus, often described as a ringing in the ears, affects a significant portion of the population, varying in perception and severity.This systematic review investigates the correlation between tinnitus and temporomandibular joint disorders (TMDs) within a PRISMA-compliant framework, ensuring methodological transpare…

While there is a very high rate of comorbidity of autism and ADHD, there are controversies about prescribing stimulants in children with autism. This is a systematic review about the effect of stimulants on irritability in children with both autism and ADHD.A systematic review was conducted to study the possible effect…

The ability of stem cells to differentiate into various lineages has made them powerful tools of regenerative medicine and applicable to multiple human diseases. Of particular interest, amniotic fluid-derived stem cells (AFSC) have been characterized to express both adult and embryonic cell markers, indicating them as…

The treatment of low-grade osteosarcomas is surgical resection with wide margins. In instances of dedifferentiation, a therapeutic paradigm similar to that of conventional high-grade osteosarcoma has not been adequately evaluated in these neoplasms. The main objective of this review was to define whether the addition o…

Quantitative mass spectrometry (MS)-based approaches have allowed further characterization of medulloblastoma (MB) classification and clinical/biological behavior. By investigating protein expression, as well as the role of post-translational modifications in shaping cellular activity, novel avenues of research will cl…

AIM: We find several interventions in palliative care to cover psychosocial needs and to relieve distress of patients. There is a growing interest in therapies using biographical approaches, but discussion about interventions is sparse, and there is no concept for comprehensive and sustainable provision. Research on in…

This review aimed to investigate platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) efficiency in reducing oronasal fistula during primary cleft lip and palate repair. An extensive search of PubMed, Google Scholar, Global Index Medics (WHO), PubMed Scopus, Cochrane Central, Proquest was performed up to march 202…

Child marriage, defined as the union of a child under 18 years with an adult or another child, remains a pervasive issue globally, particularly in sub-Saharan Africa. Despite international efforts to eradicate this practice, approximately 15 million girls marry before 18 annually, infringing on their basic human rights…

BACKGROUND: Rapid population aging has increased the demand for integrated care for older adults, particularly in rural areas where older adults frequently experience chronic illness, frailty, and limited access to healthcare. Caregivers, both formal and informal, play a central role in supporting the wellbeing of olde…

OBJECTIVE: This systematic review aimed to evaluate the risk of bisphosphonate-associated osteonecrosis of the jaws (BRONJ) in patients with diabetes mellitus (DM). STUDY DESIGN: A two-phase PROSPERO-registered systematic review (CRD420251101934) was conducted in accordance with the PRISMA guidelines. Search strategie…

OBJECTIVES: To assess the impact of ceftazidime-avibactam on 30-day all-cause mortality in patients with OXA-48 producinginfections, in comparison to alternative best available therapy (BAT). METHODS: Systematic review and meta-analysis of observational studies comparing 30-day mortality outcomes in patients infected…

BACKGROUND: Midwives are essential providers of maternal and neonatal healthcare, particularly in sub-Saharan Africa, where they play a crucial role in managing obstetric complications and improving maternal and child health outcomes. Despite their significance, limited research has explored their lived experiences in…