42,457 papers found

: Gliomas are the most common primary tumours of the central nervous system. Despite a multimodal therapeutic approach combining surgery, radiotherapy, and temozolomide (TMZ), treatment remains highly challenging, and the prognosis is poor. One of the potential molecular targets that may improve therapeutic outcomes is…

INTRODUCTION: Cognitive impairment is considered a challenge in medication management for both the affected patient as well as their caregiver. Numerous studies have investigated interventions aiming to improve medication therapy safety in this population; however, there is insufficient knowledge on interventions which…

The treatment of migraine is hampered by inter-individual variability, leading to an inefficient "trial and error" approach. Artificial intelligence (AI) and machine learning (ML) offer a path towards precision medicine by predicting therapeutic outcomes. This scoping review systematically evaluates the evidence for AI…

STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To evaluate inter- and intra-observer reliability of the Lenke classification for adolescent idiopathic scoliosis (AIS) and identify methodological factors influencing agreement. The Lenke system is widely used in AIS surgical planning. While initial report…

INTRODUCTION: Considering the importance of differentiating between benign and malignant thyroid nodules, this study explores the individual predictors of malignancy. Recent research has focused on individual predictors of isolation, but a comprehensive assessment of these predictors is essential to improve diagnostic…

PURPOSE: Laryngopharyngeal reflux (LPR) is a medical condition in which gastric contents reflux, directly or indirectly, causing morphological and neurological alterations in the upper aerodigestive system. Alginates are a common solution to this problem. METHODS: We conducted a PRISMA-compliant systematic review of t…

Patients with mechanical heart valves require lifelong anticoagulation primarily due to the thrombogenic nature of these valves. Warfarin has been the mainstay of therapy, but its drug-drug interactions and frequent monitoring requirements have diverted attention toward DOACs (direct oral anticoagulants) such as apixab…

UNLABELLED: Down syndrome regression disorder (DSRD) is characterized by an acute or subacute neurocognitive regression that severely impacts the autonomy and quality of life of individuals with Down syndrome (DS). Despite its growing recognition, understanding of the condition remains limited, particularly regarding i…

BACKGROUND: Simulation immerses learners in guided replications of real-life experiences. Simulation-based learning in the health profession allows trainees and professionals to practice skills in a controlled environment using various modalities, enhancing patient safety and minimizing clinical errors. OBJECTIVE: To…

OBJECTIVE: Cancer can have a profound impact on the life of the patient, presenting challenges such as dealing with complex healthcare models and psychological burden. Implementing design thinking (DT) in cancer care can improve the quality of life for patients. Although DT has been used in healthcare, there is limited…

INTRODUCTION: There has been a significant increase in antipsychotic usage, particularly belonging to second-generation antipsychotics (SGAs), in the management of severe mental illnesses (SMIs) over the past few decades, but their impact on oral health is unclear. This review evaluated the oral side effects of the SGA…

PURPOSE: To assess the current extent of pharmacy students' involvement in collecting best possible medication histories (BPMHs) in different hospital settings, as well as the accuracy and financial implications of the collected BPMHs. SUMMARY: A scoping review methodology was conducted following best-practice Cochran…

Emotional and cognitive impairments are comorbidities commonly associated with chronic inflammatory pain. To summarize the rules and mechanisms of comorbidities in a complete Freund's adjuvant (CFA)-induced pain model, we conducted a systematic review of 66 experimental studies identified in a search of three databases…

AIM: To conduct a concept analysis of evidence-based leadership in a nursing context. METHODS: Rodgers' evolutionary method was employed to identify attributes, antecedents, consequences, definitions and surrogate and related terms. DATA SOURCE: We systematically searched three databases (PubMed, Cumulative Index to…

INTRODUCTION: Hemorrhagic shock demands swift intervention. Management involves the rapid infusion of blood products to restore circulation and uphold tissue perfusion. The aim of this study was to evaluate the effectiveness of prehospital plasma administration in trauma patients, comparing outcomes with normal saline.…

Overweight and obesity are linked to the severity of infections and the development of chronic conditions among children and adolescents in Ghana. Hence, estimating the current prevalence and its determinants is imperative to guide public health interventions. This review mapped evidence on the prevalence and determina…

Glioma is a type of cancer that affects the central nervous system and necessitates a non-invasive diagnostic and prognostic assessment. MicroRNAs (miRNAs) play a crucial role in glioma and can provide valuable information about the prognosis of patients with this condition. MiR-124 is associated with molecules that pl…

BACKGROUND: Post-traumatic elbow stiffness is a common consequence following trauma or surgery, resulting in significant limb disability, with a negative impact on daily life. Although conservative treatment is the first-line approach, it is not yet known which is most suitable and effective. OBJECTIVE: To investigate…

The objective of this review article is to systematically identify the caffeine placebo effect in sport and exercise activities. We selected randomized controlled trial studies to better understand the impact of caffeine and its placebo effect on sports performance. We extracted a set of articles that refer strictly to…

The Water, Sanitation, and Hygiene (WASH) interventions have been acknowledged for their role in the public health and educational outcomes. While there are strong evidences that reveal that WASH facilities do reduce the prevalence of infectious diseases and improve the learning environment, data remain thin and equivo…