42,256 papers found

BACKGROUND: Acupoint catgut embedding (ACE) is a therapeutic method for pain management that involves inserting a thread or catgut into the body with anti-hyperalgesic effect. This study aims to systematically review and comprehensively compare the effectiveness of ACE with that of each comparator in the treatment of k…

BACKGROUND: Rhus coriaria L. (Anacardiaceae), known as Sumac, is a commonly used spice, which is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and may be beneficial for cardiovascular disease risk factors. This comprehensive systematic revi…

BACKGROUND: Digital interventions can provide cost-effective, quality health care for patients with chronic conditions. Patients with chronic conditions often are burdened by a substantial load of adhering to a treatment regimen and suffer from impacts on their function and well-being. This treatment burden has consequ…

Erectile dysfunction (ED) is a common and distressing complication following radical prostatectomy, significantly affecting patients' quality of life. Low-intensity extracorporeal shock wave therapy (LI-ESWT) has emerged as a non-invasive modality aimed at enhancing erectile function through tissue regeneration and imp…

Potassium channels, particularly the sodium-activated Slo2 (Slack/KCNT1) channels, play a critical role in regulating neuronal excitability and protein synthesis. Emerging evidence suggests a strong association between Slo2 channel dysfunction and the development of intellectual disability (ID), including conditions li…

BACKGROUND: Food craving (FC) is associated with a higher body mass index (BMI) and less healthy food choices. Mindfulness-based interventions (MBIs) have garnered interest as a strategy to address maladaptive eating behaviors. We conducted a systematic review and meta-analysis to evaluate the effectiveness of MBIs in…

OBJECTIVES: This systematic review and meta-analysis investigates the association between statin use and clinical outcomes in non-small cell lung cancer (NSCLC) patients, focusing on the therapeutic potential of statins and their impact on patient prognosis. DESIGN: The review includes a mix of prospective and retrosp…

Vitamin K2 refers to a subfamily of vitamin K isoforms known as Menaquinones and, therefore, indicated as MK-n, the "n" indicating the number of isoprene units present in the side chain. Like the other members of the Vitamin K family, K2 is an enzymatic cofactor for the γ-glutamyl carboxylase (GGCX). This enzyme'…

BACKGROUND: Achalasia is a debilitating esophageal motility disorder characterized by absent peristalsis and incomplete relaxation of the lower esophageal sphincter (LES). Myotomy procedures-primarily peroral endoscopic myotomy (POEM) and laparoscopic Heller myotomy (LHM)-aim to reduce LES pressure and alleviate dyspha…

OBJECTIVE: This systematic review and meta-analysis aimed to investigate the potential association between peri‑implantitis (PI) and peri‑implant oral malignancies (PIOM). DATA AND SOURCES: Systematic searches were conducted in Medline (PubMed), Embase, CENTRAL, and Web of Science up to December 10, 2024…

BACKGROUND: The use of preoperative surgical antibiotic prophylaxis is effective in preventing surgical site infection. However, obesity, a major risk factor for surgical site infection, affects the pharmacokinetics and effectiveness of surgical antibiotic prophylaxis. Evidence for weight-based surgical antibiotic prop…

OBJECTIVE: The goal of this systematic review was to verify whether the gingival phenotype (thick or thin) could impact the dental implant survival rate by affecting the marginal bone. METHODS: The search was carried out on PubMed/MedLine, PubMed Central, and B-On databases. The research question was: "Does gingival p…

BACKGROUND: Adults with congenital heart disease (ACHD) can face a lifelong risk of premature cardiovascular events. Endothelial dysfunction and arterial stiffness may be some of the key mechanisms involved. Early identification of endothelial damage in ACHD could be crucial to mitigate the adverse events. This systema…

PURPOSE: While strengthening exercises are recommended for knee osteoarthritis (KOA) treatment, the optimal type of muscle contraction remains unclear, with current research showing conflicting results. This network meta-analysis (NMA) aims to evaluate the efficacy of lower limb strengthening exercises based on differe…

BACKGROUND: Psoriasis, a chronic autoimmune condition, imposes significant burdens on patients' well-being. While corticosteroid medications are commonly used, their prolonged use presents risks. Statins, known for their immunoregulatory and anti-inflammatory properties, have emerged as potential alternatives. Previous…

BACKGROUND: Latin America (LATAM) encompasses a vast region with diverse populations. Despite publicly funded health care systems providing universal coverage, significant socioeconomic and ethno-racial disparities persist in health care access across the region. Breast cancer (BC) incidence and mortality rates in Braz…

INTRODUCTION: Cardiovascular disease (CVD) accounts for 18 million deaths per year, disproportionately burdens under-represented racial and ethnic groups, and has economic costs greater than any other health condition. Participation in youth sport may be an effective strategy to improve CVD-related risk factors…

INTRODUCTION: Models of care (MoCs) describe evidence-informed healthcare that should be delivered to patients. Several MoCs have been implemented for low back pain (LBP) to reduce evidence-to-practice gaps and increase the effectiveness and sustainability of healthcare services. OBJECTIVE: To synthesise research evid…

INTRODUCTION: Dementia risk is substantially elevated in patients with diabetes. However, evidence on dementia risk associated with various antidiabetic regimens is still limited. This study aims to comprehensively investigate the risk of dementia and Alzheimer's disease (AD) associated with various antidiabetic classe…