42,335 papers found

OBJECTIVE: To summarise the extent to which narrative text fields in administrative health data are used to gather information about the event resulting in presentation to a health care provider for treatment of an injury, and to highlight best practise approaches to conducting narrative text interrogation for injury s…

OBJECTIVES/BACKGROUND: This review summarizes current insights into Reversible cerebral vasoconstriction syndrome (RCVS) diagnosis, management, and outcomes. RCVS is a cerebrovascular disorder characterized by recurrent thunderclap headaches and transient segmental vasoconstriction of cerebral arteries, typically resol…

BACKGROUND: Preadmission metformin may lower mortality in diabetic sepsis patients, but evidence is conflicting, necessitating a systematic review and meta-analysis for confirmation. METHODS: We systematically searched MEDLINE (via PubMed), EMBASE, and Cochrane CENTRAL from inception to September 1, 2025, for cohort s…

Adult patients supported with extracorporeal membrane oxygenation (ECMO) frequently require invasive diagnostic, therapeutic, surgical, or bedside procedures during ongoing extracorporeal support. These procedures are clinically challenging because ECMO-related anticoagulation, platelet dysfunction, acquired coagulopat…

High-grade B-cell lymphomas (HGBCLs) withandortranslocations, colloquially referred to as double-hit lymphomas (and abbreviated here to DHL), are aggressive malignancies. Differentiating DHL from non-DHL HGBCLs is important, as DHL patients may benefit from more intensive treatment regimes. We aimed to identify predict…

BACKGROUND: Given the growing global public health burden of Alzheimer's disease, this study used the Bayesian network meta-analysis to assess the effects of pharmacological and non-pharmacological interventions on cognitive function in the population with Alzheimer's disease. METHODS: Two investigators screened the l…

BACKGROUND: Functional abdominal pain disorders (FAPDs) are common pediatric gut-brain interaction disorders that substantially impair quality of life and lack effective pharmacologic or behavioral treatments. Given their biological plausibility, probiotics have emerged as a promising therapy, yet evidence remains inco…

Concurrent chemoradiotherapy (CRT) remains a standard treatment for locally advanced esophageal cancer, yet the approach poses significant cardiotoxic risks due to the proximity of the esophagus to cardiac structures. This systematic review synthesized recent evidence from observational st…

BACKGROUND: Acupoint catgut embedding (ACE) is a therapeutic method for pain management that involves inserting a thread or catgut into the body with anti-hyperalgesic effect. This study aims to systematically review and comprehensively compare the effectiveness of ACE with that of each comparator in the treatment of k…

BACKGROUND: Rhus coriaria L. (Anacardiaceae), known as Sumac, is a commonly used spice, which is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and may be beneficial for cardiovascular disease risk factors. This comprehensive systematic revi…

BACKGROUND: Digital interventions can provide cost-effective, quality health care for patients with chronic conditions. Patients with chronic conditions often are burdened by a substantial load of adhering to a treatment regimen and suffer from impacts on their function and well-being. This treatment burden has consequ…

Erectile dysfunction (ED) is a common and distressing complication following radical prostatectomy, significantly affecting patients' quality of life. Low-intensity extracorporeal shock wave therapy (LI-ESWT) has emerged as a non-invasive modality aimed at enhancing erectile function through tissue regeneration and imp…

Potassium channels, particularly the sodium-activated Slo2 (Slack/KCNT1) channels, play a critical role in regulating neuronal excitability and protein synthesis. Emerging evidence suggests a strong association between Slo2 channel dysfunction and the development of intellectual disability (ID), including conditions li…

BACKGROUND: Food craving (FC) is associated with a higher body mass index (BMI) and less healthy food choices. Mindfulness-based interventions (MBIs) have garnered interest as a strategy to address maladaptive eating behaviors. We conducted a systematic review and meta-analysis to evaluate the effectiveness of MBIs in…

OBJECTIVES: This systematic review and meta-analysis investigates the association between statin use and clinical outcomes in non-small cell lung cancer (NSCLC) patients, focusing on the therapeutic potential of statins and their impact on patient prognosis. DESIGN: The review includes a mix of prospective and retrosp…

Vitamin K2 refers to a subfamily of vitamin K isoforms known as Menaquinones and, therefore, indicated as MK-n, the "n" indicating the number of isoprene units present in the side chain. Like the other members of the Vitamin K family, K2 is an enzymatic cofactor for the γ-glutamyl carboxylase (GGCX). This enzyme'…

BACKGROUND: Achalasia is a debilitating esophageal motility disorder characterized by absent peristalsis and incomplete relaxation of the lower esophageal sphincter (LES). Myotomy procedures-primarily peroral endoscopic myotomy (POEM) and laparoscopic Heller myotomy (LHM)-aim to reduce LES pressure and alleviate dyspha…

OBJECTIVE: This systematic review and meta-analysis aimed to investigate the potential association between peri‑implantitis (PI) and peri‑implant oral malignancies (PIOM). DATA AND SOURCES: Systematic searches were conducted in Medline (PubMed), Embase, CENTRAL, and Web of Science up to December 10, 2024…

OBJECTIVE: The goal of this systematic review was to verify whether the gingival phenotype (thick or thin) could impact the dental implant survival rate by affecting the marginal bone. METHODS: The search was carried out on PubMed/MedLine, PubMed Central, and B-On databases. The research question was: "Does gingival p…