43,361 papers found

BACKGROUND: Central molecular mediators-including hypoxia-inducible factors (HIF-1α/HIF-2α), MYC, wild-type and mutant p53, NF-κB, STAT3, SREBPs, NRF2, and KRAS-orchestrate these pathways by linking nutrient availability to oncogenic signalling, epigenetic reprogramming, and immune-metabolic crosstalk…

INTRODUCTION: The global prevalence of diabetes mellitus (DM) has risen markedly, with patients facing a substantially higher risk of atherosclerotic cardiovascular disease (ASCVD) and related mortality. Although lipid-modifying agents, including statins, fibrates, cholesterol absorption inhibitors, proprotein converta…

OBJECTIVES: The aim of this study is to indirectly compare and rank the different drugs that have been studied in randomized clinical trials (RCTs) in patients with tardive dyskinesia (TD) in terms of their efficacy in ameliorating the symptoms of TD and safety. DESIGN: A network meta-analysis and a systematic review w…

Proton pump inhibitors (PPIs) are widely used to prevent acid-related complications, yet concerns persist about infectious harm. Observational studies have linked PPIs toinfection (CDI) and pneumonia whereas randomized controlled trials (RCTs) consistently show reductions in upper gastrointestinal bleeding. We therefor…

Cerebral cavernous malformations (CCMs) are vascular lesions in the brain, presenting risks of intracerebral hemorrhage (ICH) and non-hemorrhagic focal neurological deficit (NH-FND). Currently, no effective medical therapy exists for CCMs, and treatment options limited to surgical resection and stereotactic radiosurger…

BACKGROUND: Primary dysmenorrhea is a leading cause of job and school absenteeism among young females. Despite its high prevalence, contemporary medicine offers limited treatment options. Herbaceous members of the Apiaceae family, such as Pimpinella anisum L., Anethum sowa L.,Anethum graveolens L.,Cuminum cyminum L., a…

PURPOSE: Propranolol, a non-selective beta-blocker characterized by high lipid solubility, is extensively prescribed for cardiovascular and central nervous system disorders. Nevertheless, it is frequently implicated in intentional overdoses due to its central nervous system penetration and membrane-stabilizing properti…

Persistent apical periodontitis is a common cause of endodontic failure. While nonsurgical retreatment (NS-ReTx) is the typical first-line option used to manage this condition, its reported success varies depending on clinical, radiographic, and methodological factors despite recent advances that improve case managemen…

Spinal cord injury (SCI) represents a devastating condition with profound neurological consequences, and the optimal timing of surgical decompression remains controversial. This systematic review and meta-analysis evaluated the impact of early versus late surgical intervention on neurological outcomes and mortality in…

Conventional white light endoscopy (WLE) has limited sensitivity for detecting subtle gastrointestinal lesions, leading to missed diagnoses and interval cancers. Advanced imaging modalities, including narrow band imaging (NBI), linked color imaging (LCI), blue laser imaging (BLI), autofluorescence imaging (AFI), and ar…

BACKGROUND: Manufactured Chinese herbal formulas (MCHFs) are Chinese patent medicine preparations made from a variety of herbal ingredients. These formulas are processed into specific dosage forms in accordance with defined prescriptions and manufacturing procedures, and are intended for the prevention and treatment of…

BACKGROUND: This network meta-analysis (NMA) aims to compare the relative efficacy of oral Chinese patent medicine combined with transarterial chemoembolization (TACE) for treating hepatocellular carcinoma (HCC). METHODS: Databases, including China National Knowledge Infrastructure, Wanfang, Weipu, PubMed, Embase, Web…

BACKGROUND: Severe nasal deviation is a complex deformity affecting the esthetics and functionality of the nose, creating an asymmetrical appearance due to septal misalignment. Advances in nasal anatomy and biomechanics have led to the use of grafting materials, such as septal extension grafts. However, its efficacy re…

BACKGROUND: Adjusting basal insulin doses is essential for lowering blood glucose while minimizing the risk of hypoglycemia. Despite various basal insulin titration strategies being available, their comparative effectiveness remains unclear. PURPOSE: To compare the effectiveness of different basal insulin titration st…

Aspirin as an agent for thromboprophylaxis in patients with total knee replacement (TKR) and total hip replacement (THR) is gaining a lot of importance owing to its efficacy and safety in preventing venous thromboembolism (VTE) complications. The current guidelines do not recommend aspirin over other anticoagulants as…

BACKGROUND: The 1-3-7 approach to eliminate malaria was first implemented in China in 2012. It has since been expanded to multiple countries, but no systematic review has examined the evidence for its use. A systematic review was conducted aiming to evaluate the impact and effectiveness of the strategy and identify key…

This study aimed to systematically review existing randomized clinical trials on the effect of dietary interventions on endometriosis. A search was performed on the Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Clinical Trials, EMBASE, PubMe…

INTRODUCTION: Plantar fasciopathy (PF) is a common musculoskeletal condition characterized by heel pain and functional impairment. Extracorporeal shock wave therapy (ESWT) has gained increasing interest in the treatment of PF, but the optimal ESWT program is still debated. Therefore, this systematic review with meta-an…

BACKGROUND: Time-restricted feeding (TRF), a form of intermittent fasting, limits daily caloric intake to a 6-12 hour window and has been shown to effectively promote weight loss and improve overall health. This systematic review and meta-analysis aimed to compare the effects of TRF versus normal diet (ND) on ph…