97,494 papers found

INTRODUCTION: Since the late 1990s, a number of factors have reduced the threshold for parathyroidectomy in patients with primary hyperparathyroidism. This study examined whether this has translated into increased numbers of parathyroid operations over the last decade. METHODS: A retrospective analysis was performed o…

INTRODUCTION: In the last few decades mortality from cancer among children and adolescents has not decreased homogeneously in industrialized countries. The aim of this study was to determine the epidemiological pattern and temporal trend of mortality from cancer in individuals aged less than 20 years old living in the…

Vaginal yolk sac tumor is a rare malignant germ-cell tumor occurring most commonly in young girls. The treatment has evolved over the last 3 decades from radical surgery to conservative surgery with chemotherapy to chemotherapy alone. Here we present a case of a 6-month-old girl successfully treated with upfront surger…

BACKGROUND: A serum-free, highly purified Vero rabies vaccine (PVRV-NG) has been developed with no animal or human components and low residual DNA content. A phaseII randomized clinical study aimed to demonstrate the non-inferiority of the immune response and assess the safety profile of PVRV-NG versus a licensed human…

Extended dissection of the mental area has been used successfully in the last 15 years, in the routine rhytidectomy, to solve the problem of the senile mental, also called the "witch's chin." After the face and neck dissection, the chin skin is completely dissected at the same anatomical level of the face and finally m…

BACKGROUND: Tooth autotransplantation is the surgical movement of a tooth from one region of the mouth to another in the same patient. Mostly, this treatment method is used in patients whose teeth are in the development phase, yet it also constitutes an alternative solution for adult patients. MATERIAL AND METHODS: Th…

BACKGROUND: Physical and psychological disorders in adolescence may lead to specific food behaviours. The aim of this work was to make a group of adolescents full actors of the conception and realization of a study on their food consumption and attitudes. POPULATION AND METHODS: Seventeen self-selected adolescents (ag…

Over the last 10 to 20 years, there have been significant improvements in the fields of both autologous and allogenic transplantation [...].

Fossil evidence indicates that millipedes were the first animals adapted to life on land about 425 million years ago, becoming the very first land animals and beating vertebrates by a staggering 50 million years.These multi-legged arthropods provide a vital ecological role in forests by decomposing coarse organic matte…

Thalassemia is the commonest hemoglobinopathy in Southeast Asia. Kidney dysfunction is an underreported sequelae in children with thalassemia. We conducted a retrospective study to identify the prevalence of and predisposing factors for kidney dysfunction in children with transfusion-dependent thalassemia (TDT).Abnorma…

INTRODUCTION: Over the last few years, lung cancer screening by low-dose CT scan has demonstrated a decrease in lung cancer mortality. While this method has been in use since 2013 in the United States of America, no European country has yet implemented a systematic screening program. We hereby report the results from t…

Inherited neuromuscular disorders inevitably result in severe lung volume restriction associated with high morbidity and mortality. The aim of this retrospective study was to evaluate the long-term effects of the regular use of mechanical insufflation/exsufflation on the course of the vital capacity. This retrospective…

INTRODUCTION: In the last decade there were significant changes in breast cancer mortality that is declining since the 90 s in several countries. The aim of this study was to quantify the variation of the female breast cancer mortality rates, in Portugal and in different regions of the country, considering the changes…

This national multicenter study by the French Task Force on Osteoporosis Research and Information (Groupe de Recherche et d'Information sur l'Ostéoporose GRIO) was carried out to define clinical features in women presenting with a first osteoporosis-related vertebral crush fracture. Seventy-four patients with a le…

This paper provides an update for 2014 on the burden of cardiovascular disease (CVD), and in particular coronary heart disease (CHD) and stroke, across the countries of Europe. Cardiovascular disease causes more deaths among Europeans than any other condition, and in many countries still causes more than twice as many…

The world of childhood diabetes has seen more changes in clinical care being introduced in recent years than many subspecialty areas of clinical practice. This review identifies some of the key underlying evidence and considers the implications for clinical teams that personal experience of these developments has highl…

BACKGROUND: Tako-tsubo syndrome (TTS) in its typical (apical) and atypical (non-apical) forms is being increasingly recognized in the West owing to early systematic coronary angiography in acute coronary syndromes (ACS). AIM OF THE STUDY: To assess the incidence, the clinical characteristics and the outcome of TTS in…

Screening for biologics, in particular antibody drugs, has evolved significantly over the last 20 years. Initially, the screening processes and technologies from many years experience with small molecules were adopted and modified to suit the needs of biologics discovery. Since then, antibody drug discovery has matured…

Patient referrals very frequently occur for ill-defined vertigo that appeared some months or even years after a trauma. These should not, however, be considered as cases of functional vertigo. The vertigo is very real, may last several years and constitute a genuine disorder. Such cases are amply described in the liter…

Sexual dysfunctions are common experiences that often impact negatively on the health and well-being of affected individuals. We used baseline questionnaire data from 62,675 Danes aged 15-89 years, who participated in the cohort study Project SEXUS 2017-2018, to yield nationally representative estimates of the pre…