382,842 papers found

Meta-analysis is increasingly being used in clinical research. While the meta-analytical algorithms for pooling the results of studies using non-censored end-points are now sufficiently standardized, the management of trials based on censored end-points is still controversial, and specific algorithms of meta-analysis a…

Publication bias is a recognized phenomenon, i.e. studies with statistically significant results are more likely to be published than those finding no difference between the groups studied. Summarized odds ratio calculated from odds ratios of published studies in a meta-analysis may be overestimated because of publicat…

The question of whether follicular aspiration of oocytes alters the quality of the luteal phase remains unanswered. Progesterone appears to be necessary for implantation and maintenance of an early intrauterine pregnancy and this partly has been the basis for recommending luteal phase supplementation with progesterone…

BACKGROUND: Current research has proved that psoriasis is associated with serum uric acid (SUAC) levels. Our purpose is to clarify SUAC levels and the incidence of hyperuricemia in psoriasis patients, and to compare SUCA levels in different groups' psoriasis patients. METHODS: We plan to search 7 electronic bibliograp…

The authors summarize their experience in the conduct of meta-analysis of individual participants' data (MIPD) with time-to-event analyses in the field of genetic epidemiology. The MIPD offers many advantages compared with a meta-analysis of the published literature. These include standardization of case definitions, o…

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Khaohoen A, Powcharoen W, Yoda N, Rungsiyakull C, Rungsiyakull P. Accuracy in dental implant placement: A systematic review and meta-analysis comparing computer-assisted (static, dynamic, robotics) and non-computer-assisted (freehand, conventional guide) approaches. J Prosth…

Model-based recursive partitioning (MOB) and its extension, metaMOB, are tools for identifying subgroups with differential treatment effects. When pooling data from various trials the metaMOB approach uses random effects to model the heterogeneity of treatment effects. In situations where interventions offer only small…

Global literature is ever-growing and physicians rely on it for evidence-based decision making. Review articles summarize available literature and provide the current state of knowledge on a given topic. Various review types exist, the main ones being narrative and systematic reviews. The former are based on studies se…

To illustrate that bias associated with indirect treatment comparison and network meta-analyses can be reduced by adjusting for outcomes on common reference arms.Approaches to adjusting for reference-arm effects are presented within a causal inference framework. Bayesian and Frequentist approaches are applied to three…

Results from single-case studies are being synthesized using three-level models in which repeated observations are nested in participants, which in turn are nested in studies. We examined the performance of these models under conditions in which the errors associated with the repeated observations (the Level-1 errors)…

PURPOSE: Conducting meta-analyses is an exciting and rewarding way of summarizing and quantifying the current knowledge, which is also becoming increasingly important in clinical research. There are many articles published on interpreting meta-analysis and specific statistical methods, which makes it challenging to obt…

This commentary critiques the statistical framing and clinical implications of Ramos et al.'s meta-analysis comparing one-anastomosis and Roux-en-Y gastric bypass. While OAGB shows non-inferiority for type 2 diabetes remission under select conditions, its elevated risk of bile reflux and GERD limits its broad applicabi…

We read with great interest the recent meta-analysis by Dai et al. comparing the KangDuo (KD) and da Vinci (DV) robotic systems in radical prostatectomy (RP). Their findings highlight the comparable perioperative outcomes of both systems despite longer operative times with KD. While the study provides valuable insights…

PURPOSE OF REVIEW: Over the past decade, the number of studies published using network meta-analyses (NMAs) has rapidly increased, and there have been continued advancements to further advance this analysis approach. Due to the fast moving and changing landscape in the infancy of NMA methodology, there is a lack of con…

The recent systematic review and meta-analysis by de Oliveria Vacchi, Martha, and Macagnan (2022) on the effect of inspiratory muscle training (IMT) and its association with physical rehabilitation in preoperative anatomic pulmonary resection raises some interesting findings, and the authors should be congratulated for…

Comments on the meta-analysis by G. M. Burlingame et al. (see record 2020-37337-001) on group therapy in schizophrenia. The commenting authors explain why they think that the meta-analysis is seriously flawed and should be recalculated and updated. First, however, they briefly reflect on the role of meta-analyses in co…

The pooled estimate of a recent meta-analysis concluded that rate of reoperation at 1 year was significantly higher in Aortic valve repair (8.82% vs 3.70%) as compared with aortic valve replacement in patients with aortic regurgitation (odds ratio = 2.67, 95% confidence interval [1.08, 3.62], P =&#…

Meta-analysis is a statistical procedure for analyzing the combined data from different studies, and can be a major source of concise up-to-date information. The overall conclusions of a meta-analysis, however, depend heavily on the quality of the meta-analytic process, and an appropriate evaluation of the quality of m…

Network meta-analysis (NMA), also known as multiple treatment comparisons, is commonly used to incorporate direct and indirect evidence comparing treatments. With recent advances in methods and software, Bayesian approaches to NMA have become quite popular and allow models of previously unanticipated complexity. Howeve…

Sequential stopping rules allow hypotheses to be tested using smaller sample sizes than are possible under conventional methods, while controlling the Type I and II error rates. However, the consequences of using such procedures when combining studies in a meta-analysis have rarely been discussed. For a primary study t…